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Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses

Miguel Gozalo Marcilla UGent, Stijn Schauvliege UGent, Stefanie Segaert UGent, Luc Duchateau UGent and Frank Gasthuys UGent (2012) VETERINARY ANAESTHESIA AND ANALGESIA. 39(1). p.49-58
abstract
Objective To investigate the influence of a dexmedetomidine constant rate infusion (CRI) in horses anaesthetized with isoflurane. Study design Prospective, randomized, blinded, clinical study. Animals Forty adult healthy horses (weight mean 491 +/- SD 102 kg) undergoing elective surgery. Methods After sedation [dexmedetomidine, 3.5 mu g kg(-1) intravenously (IV)] and induction IV (midazolam 0.06 mg kg(-1), ketamine 2.2 mg kg(-1)), anaesthesia was maintained with isoflurane in oxygen/air (FiO(2) 55-60%). Horses were ventilated and dobutamine was administered when hypoventilation [arterial partial pressure of CO(2) > 8.00 kPa (60 mmHg)] and hypotension [arterial pressure 70 mmHg] occurred respectively. During anaesthesia, horses were randomly allocated to receive a CRI of dexmedetomidine (1.75 mu g kg(-1) hour(-1)) (D) or saline (S). Monitoring included end-tidal isoflurane concentration, cardiopulmonary parameters, and need for dobutamine and additional ketamine. All horses received 0.875 mu g kg(-1) dexmedetomidine IV for the recovery period. Age and weight of the horses, duration of anaesthesia, additional ketamine and dobutamine, cardiopulmonary data (ANOVA), recovery scores (Wilcoxon Rank Sum Test), duration of recovery (t-test) and attempts to stand (Mann-Whitney test) were compared between groups. Significance was set at p < 0.05. Results Heart rate and arterial partial pressure of oxygen were significantly lower in group D compared to group S. An interaction between treatment and time was present for cardiac index, oxygen delivery index and systemic vascular resistance. End-tidal isoflurane concentration and heart rate significantly increased over time. Packed cell volume, systolic, diastolic and mean arterial pressure, arterial oxygen content, stroke volume index and systemic vascular resistance significantly decreased over time. Recovery scores were significantly better in group D, with fewer attempts to stand and significantly longer times to sternal position and first attempt to stand. Conclusions and clinical relevance A dexmedetomidine CRI produced limited cardiopulmonary effects, but significantly improved recovery quality.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
recovery, horses, MINIMUM ALVEOLAR CONCENTRATION, constant rate infusion, cardiopulmonary effects, dexmedetomidine, CARDIOVASCULAR FUNCTION, GENERAL-ANESTHESIA, HALOTHANE, MEDETOMIDINE, PONIES, DETOMIDINE, COMBINATION, LIDOCAINE, DOGS
journal title
VETERINARY ANAESTHESIA AND ANALGESIA
Vet. Anaesth. Analg.
volume
39
issue
1
pages
49 - 58
Web of Science type
Article
Web of Science id
000298329100006
JCR category
VETERINARY SCIENCES
JCR impact factor
1.34 (2012)
JCR rank
43/142 (2012)
JCR quartile
2 (2012)
ISSN
1467-2987
DOI
10.1111/j.1467-2995.2011.00672.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2101526
handle
http://hdl.handle.net/1854/LU-2101526
date created
2012-05-08 13:41:00
date last changed
2012-05-08 15:03:54
@article{2101526,
  abstract     = {Objective To investigate the influence of a dexmedetomidine constant rate infusion (CRI) in horses anaesthetized with isoflurane. 
Study design Prospective, randomized, blinded, clinical study. 
Animals Forty adult healthy horses (weight mean 491 +/- SD 102 kg) undergoing elective surgery. 
Methods After sedation [dexmedetomidine, 3.5 mu g kg(-1) intravenously (IV)] and induction IV (midazolam 0.06 mg kg(-1), ketamine 2.2 mg kg(-1)), anaesthesia was maintained with isoflurane in oxygen/air (FiO(2) 55-60\%). Horses were ventilated and dobutamine was administered when hypoventilation [arterial partial pressure of CO(2) {\textrangle} 8.00 kPa (60 mmHg)] and hypotension [arterial pressure 70 mmHg] occurred respectively. During anaesthesia, horses were randomly allocated to receive a CRI of dexmedetomidine (1.75 mu g kg(-1) hour(-1)) (D) or saline (S). Monitoring included end-tidal isoflurane concentration, cardiopulmonary parameters, and need for dobutamine and additional ketamine. All horses received 0.875 mu g kg(-1) dexmedetomidine IV for the recovery period. Age and weight of the horses, duration of anaesthesia, additional ketamine and dobutamine, cardiopulmonary data (ANOVA), recovery scores (Wilcoxon Rank Sum Test), duration of recovery (t-test) and attempts to stand (Mann-Whitney test) were compared between groups. Significance was set at p {\textlangle} 0.05. 
Results Heart rate and arterial partial pressure of oxygen were significantly lower in group D compared to group S. An interaction between treatment and time was present for cardiac index, oxygen delivery index and systemic vascular resistance. End-tidal isoflurane concentration and heart rate significantly increased over time. Packed cell volume, systolic, diastolic and mean arterial pressure, arterial oxygen content, stroke volume index and systemic vascular resistance significantly decreased over time. Recovery scores were significantly better in group D, with fewer attempts to stand and significantly longer times to sternal position and first attempt to stand. 
Conclusions and clinical relevance A dexmedetomidine CRI produced limited cardiopulmonary effects, but significantly improved recovery quality.},
  author       = {Gozalo Marcilla, Miguel and Schauvliege, Stijn and Segaert, Stefanie and Duchateau, Luc and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keyword      = {recovery,horses,MINIMUM ALVEOLAR CONCENTRATION,constant rate infusion,cardiopulmonary effects,dexmedetomidine,CARDIOVASCULAR FUNCTION,GENERAL-ANESTHESIA,HALOTHANE,MEDETOMIDINE,PONIES,DETOMIDINE,COMBINATION,LIDOCAINE,DOGS},
  language     = {eng},
  number       = {1},
  pages        = {49--58},
  title        = {Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2011.00672.x},
  volume       = {39},
  year         = {2012},
}

Chicago
Gozalo Marcilla, Miguel, Stijn Schauvliege, Stefanie Segaert, Luc Duchateau, and Frank Gasthuys. 2012. “Influence of a Constant Rate Infusion of Dexmedetomidine on Cardiopulmonary Function and Recovery Quality in Isoflurane Anaesthetized Horses.” Veterinary Anaesthesia and Analgesia 39 (1): 49–58.
APA
Gozalo Marcilla, M., Schauvliege, S., Segaert, S., Duchateau, L., & Gasthuys, F. (2012). Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses. VETERINARY ANAESTHESIA AND ANALGESIA, 39(1), 49–58.
Vancouver
1.
Gozalo Marcilla M, Schauvliege S, Segaert S, Duchateau L, Gasthuys F. Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses. VETERINARY ANAESTHESIA AND ANALGESIA. 2012;39(1):49–58.
MLA
Gozalo Marcilla, Miguel, Stijn Schauvliege, Stefanie Segaert, et al. “Influence of a Constant Rate Infusion of Dexmedetomidine on Cardiopulmonary Function and Recovery Quality in Isoflurane Anaesthetized Horses.” VETERINARY ANAESTHESIA AND ANALGESIA 39.1 (2012): 49–58. Print.