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Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions

Michaël Beck UGent (2012)
abstract
The unknown, be it what exists in the deepest ocean trench or in the farthest outreach of space, has always served as food for the imagination of mankind. The discovery that human life could be successfully sustained in space opened mankind’s eyes to the infinite possibilities that were uncovered, but also raised a plethora of questions concerning the hazards linked to space travel and possible settlement of planets other than Earth. Extensive research has been conducted to determine the risks associated with space travel and to develop countermeasures against them. However, much remains to be discovered before long-term space missions are considered a feasible option. In this thesis, we considered two stressful conditions found in space that are radiation and microgravity, and we developed and used various models of space simulation. To that end, either acute or chronic irradiations were applied respectively before or during microgravity simulation on endothelial cells and on fibroblasts. These models were used to address two concerns of the European Space Agency (ESA), which are related to the cardiovascular risks associated with spaceflight and to the possibility of vertebrates reproducing in space.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
development, microgravity, space, radiation, cardiovascular
pages
XXII, 217 pages
publisher
Ghent University. Faculty of Bioscience Engineering
place of publication
Ghent, Belgium
defense location
Gent : Faculteit Bio-ingenieurswetenschappen (A0.030)
defense date
2012-05-04 16:00
ISBN
9789059895218
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
2096995
handle
http://hdl.handle.net/1854/LU-2096995
date created
2012-05-02 12:07:51
date last changed
2012-05-03 08:53:07
@phdthesis{2096995,
  abstract     = {The unknown, be it what exists in the deepest ocean trench or in the farthest outreach of space, has always served as food for the imagination of mankind. The discovery that human life could be successfully sustained in space opened mankind{\textquoteright}s eyes to the infinite possibilities that were uncovered, but also raised a plethora of questions concerning the hazards linked to space travel and possible settlement of planets other than Earth. Extensive research has been conducted to determine the risks associated with space travel and to develop countermeasures against them. However, much remains to be discovered before long-term space missions are considered a feasible option. In this thesis, we considered two stressful conditions found in space that are radiation and microgravity, and we developed and used various models of space simulation. To that end, either acute or chronic irradiations were applied respectively before or during microgravity simulation on endothelial cells and on fibroblasts. These models were used to address two concerns of the European Space Agency (ESA), which are related to the cardiovascular risks associated with spaceflight and to the possibility of vertebrates reproducing in space.},
  author       = {Beck, Micha{\"e}l},
  isbn         = {9789059895218},
  keyword      = {development,microgravity,space,radiation,cardiovascular},
  language     = {eng},
  pages        = {XXII, 217},
  publisher    = {Ghent University. Faculty of Bioscience Engineering},
  school       = {Ghent University},
  title        = {Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions},
  year         = {2012},
}

Chicago
Beck, Michaël. 2012. “Molecular Mechanisms Related to DNA Damage, Apoptosis and Inflammation in Fibroblasts and Endothelial Cells Subjected to Space Simulated Conditions”. Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
APA
Beck, Michaël. (2012). Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Vancouver
1.
Beck M. Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2012.
MLA
Beck, Michaël. “Molecular Mechanisms Related to DNA Damage, Apoptosis and Inflammation in Fibroblasts and Endothelial Cells Subjected to Space Simulated Conditions.” 2012 : n. pag. Print.