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Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions

(2012)
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Abstract
The unknown, be it what exists in the deepest ocean trench or in the farthest outreach of space, has always served as food for the imagination of mankind. The discovery that human life could be successfully sustained in space opened mankind’s eyes to the infinite possibilities that were uncovered, but also raised a plethora of questions concerning the hazards linked to space travel and possible settlement of planets other than Earth. Extensive research has been conducted to determine the risks associated with space travel and to develop countermeasures against them. However, much remains to be discovered before long-term space missions are considered a feasible option. In this thesis, we considered two stressful conditions found in space that are radiation and microgravity, and we developed and used various models of space simulation. To that end, either acute or chronic irradiations were applied respectively before or during microgravity simulation on endothelial cells and on fibroblasts. These models were used to address two concerns of the European Space Agency (ESA), which are related to the cardiovascular risks associated with spaceflight and to the possibility of vertebrates reproducing in space.
Keywords
development, microgravity, space, radiation, cardiovascular

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Citation

Please use this url to cite or link to this publication:

Chicago
Beck, Michaël. 2012. “Molecular Mechanisms Related to DNA Damage, Apoptosis and Inflammation in Fibroblasts and Endothelial Cells Subjected to Space Simulated Conditions”. Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
APA
Beck, Michaël. (2012). Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Vancouver
1.
Beck M. Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2012.
MLA
Beck, Michaël. “Molecular Mechanisms Related to DNA Damage, Apoptosis and Inflammation in Fibroblasts and Endothelial Cells Subjected to Space Simulated Conditions.” 2012 : n. pag. Print.
@phdthesis{2096995,
  abstract     = {The unknown, be it what exists in the deepest ocean trench or in the farthest outreach of space, has always served as food for the imagination of mankind. The discovery that human life could be successfully sustained in space opened mankind{\textquoteright}s eyes to the infinite possibilities that were uncovered, but also raised a plethora of questions concerning the hazards linked to space travel and possible settlement of planets other than Earth. Extensive research has been conducted to determine the risks associated with space travel and to develop countermeasures against them. However, much remains to be discovered before long-term space missions are considered a feasible option. In this thesis, we considered two stressful conditions found in space that are radiation and microgravity, and we developed and used various models of space simulation. To that end, either acute or chronic irradiations were applied respectively before or during microgravity simulation on endothelial cells and on fibroblasts. These models were used to address two concerns of the European Space Agency (ESA), which are related to the cardiovascular risks associated with spaceflight and to the possibility of vertebrates reproducing in space.},
  author       = {Beck, Micha{\"e}l},
  isbn         = {9789059895218},
  keyword      = {development,microgravity,space,radiation,cardiovascular},
  language     = {eng},
  pages        = {XXII, 217},
  publisher    = {Ghent University. Faculty of Bioscience Engineering},
  school       = {Ghent University},
  title        = {Molecular mechanisms related to DNA damage, apoptosis and inflammation in fibroblasts and endothelial cells subjected to space simulated conditions},
  year         = {2012},
}