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Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar

Josep M Antó, Mariona Pinart, Mübeccel Akdis, Charles Auffray, Claus Bachert UGent, Xavier Basagaña, Kai-Håkon Carlsen, Stefano Guerra, Leena von Hertzen, Sabina Illi, et al. (2012) JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 129(4). p.943-954
abstract
Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
phenotypes, IgE, Seventh Framework Program, Mechanisms of the Development of Allergy, Allergy, asthma, ASTHMA RESEARCH-PROGRAM, OBSTRUCTIVE PULMONARY-DISEASE, WORLD-HEALTH-ORGANIZATION, T-REGULATORY-CELLS, BIRTH-COHORT, CLUSTER-ANALYSIS, RUSSIAN KARELIA, LUNG-FUNCTION, BRONCHIAL HYPERRESPONSIVENESS, DIAGNOSTIC GATEKEEPERS
journal title
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
J. Allergy Clin. Immunol.
volume
129
issue
4
pages
943 - 954
Web of Science type
Article
Web of Science id
000302144600008
JCR category
ALLERGY
JCR impact factor
12.047 (2012)
JCR rank
1/23 (2012)
JCR quartile
1 (2012)
ISSN
0091-6749
DOI
10.1016/j.jaci.2012.01.047
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2095272
handle
http://hdl.handle.net/1854/LU-2095272
date created
2012-04-26 15:21:29
date last changed
2016-12-19 15:38:12
@article{2095272,
  abstract     = {Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL.},
  author       = {Ant{\'o}, Josep  M and Pinart, Mariona and Akdis, M{\"u}beccel and Auffray, Charles and Bachert, Claus and Basaga{\~n}a, Xavier and Carlsen, Kai-H{\aa}kon and Guerra, Stefano and von Hertzen, Leena and Illi, Sabina and Kauffmann, Francine and Keil, Thomas and Kiley, James P and Koppelman, Gerard H and Lupinek, Christian and Martinez, Fernando D and Nawijn, Martijn C and Postma, Dirkje S and Siroux, Val{\'e}rie and Smit, Henriette A and Sterk, Peter J and Sunyer, Jordi and Valenta, Rudolf and Valverde, Sergio and Akdis, Cezmi A and Annesi-Maesano, Isabella and Ballester, Ferran and Benet, Marta and Cambon-Thomsen, Anne and Chatzi, Leda and Coquet, Jonathan and Demoly, Pascal and Gan, Weiniu and Garcia-Aymerich, Judith and Gimeno-Santos, Elena and Guihenneuc-Jouyaux, Chantal and Haahtela, Tari and Heinrich, Joachim and Herr, Marie and Hohmann, Cynthia and Jacquemin, B{\'e}n{\'e}dicte and Just, Jocelyne and Kerkhof, Marjan and Kogevinas, Manolis and Kowalski, Marek L and Lambrecht, Bart and Lau, Susanne and Carlsen, Karin C L{\o}drup and Maier, Dieter and Momas, Isabelle and Noel, Patricia and Oddie, Sam and Palkonen, Susanna and Pin, Isabelle and Porta, Daniela and Punturieri, Antonello and Ranci{\`e}re, Fanny and Smith, Robert A and Stanic, Barbara and Stein, Renato T and van de Veen, Willem and van Oosterhout, Antoon JM and Varraso, Raphaelle and Wickman, Magnus and Wijmenga, Cisca and Wright, John and Yaman, Gorkem and Zuberbier, Torsten and Bousquet, Jean},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keyword      = {phenotypes,IgE,Seventh Framework Program,Mechanisms of the Development of Allergy,Allergy,asthma,ASTHMA RESEARCH-PROGRAM,OBSTRUCTIVE PULMONARY-DISEASE,WORLD-HEALTH-ORGANIZATION,T-REGULATORY-CELLS,BIRTH-COHORT,CLUSTER-ANALYSIS,RUSSIAN KARELIA,LUNG-FUNCTION,BRONCHIAL HYPERRESPONSIVENESS,DIAGNOSTIC GATEKEEPERS},
  language     = {eng},
  number       = {4},
  pages        = {943--954},
  title        = {Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar},
  url          = {http://dx.doi.org/10.1016/j.jaci.2012.01.047},
  volume       = {129},
  year         = {2012},
}

Chicago
Antó, Josep  M, Mariona Pinart, Mübeccel Akdis, Charles Auffray, Claus Bachert, Xavier Basagaña, Kai-Håkon Carlsen, et al. 2012. “Understanding the Complexity of IgE-related Phenotypes from Childhood to Young Adulthood: a Mechanisms of the Development of Allergy (MeDALL) Seminar.” Journal of Allergy and Clinical Immunology 129 (4): 943–954.
APA
Antó, J. M., Pinart, M., Akdis, M., Auffray, C., Bachert, C., Basagaña, X., Carlsen, K.-H., et al. (2012). Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 129(4), 943–954.
Vancouver
1.
Antó JM, Pinart M, Akdis M, Auffray C, Bachert C, Basagaña X, et al. Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(4):943–54.
MLA
Antó, Josep  M, Mariona Pinart, Mübeccel Akdis, et al. “Understanding the Complexity of IgE-related Phenotypes from Childhood to Young Adulthood: a Mechanisms of the Development of Allergy (MeDALL) Seminar.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 129.4 (2012): 943–954. Print.