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WUSCHEL-RELATED HOMEOBOX5 gene expression and interaction of CLE peptides with components of the systemic control add two pieces to the puzzle of autoregulation of nodulation

Maria A Osipova, Virginie Mortier UGent, Kirill N Demchenko, Victor E Tsyganov, Igor A Tikhonovich, Ludmila A Lutova, Elena A Dolgikh and Sofie Goormachtig UGent (2012) PLANT PHYSIOLOGY. 158(3). p.1329-1341
abstract
In legumes, the symbiotic nodules are formed as a result of dedifferentiation and reactivation of cortical root cells. A shoot-acting receptor complex, similar to the Arabidopsis (Arabidopsis thaliana) CLAVATA1 (CLV1)/CLV2 receptor, regulating development of the shoot apical meristem, is involved in autoregulation of nodulation (AON), a mechanism that systemically controls nodule number. The targets of CLV1/CLV2 in the shoot apical meristem, the WUSCHEL (WUS)-RELATED HOMEOBOX (WOX) family transcription factors, have been proposed to be important regulators of apical meristem maintenance and to be expressed in apical meristem "organizers." Here, we focus on the role of the WOX5 transcription factor upon nodulation in Medicago truncatula and pea (Pisum sativum) that form indeterminate nodules. Analysis of temporal WOX5 expression during nodulation with quantitative reverse transcription-polymerase chain reaction and promoter-reporter fusion revealed that the WOX5 gene was expressed during nodule organogenesis, suggesting that WOX genes are common regulators of cell proliferation in different systems. Furthermore, in nodules of supernodulating mutants, defective in AON, WOX5 expression was higher than that in wild-type nodules. Hence, a conserved WUS/WOX-CLV regulatory system might control cell proliferation and differentiation not only in the root and shoot apical meristems but also in nodule meristems. In addition, the link between nodule-derived CLE peptides activating AON in different legumes and components of the AON system was investigated. We demonstrate that the identified AON component, NODULATION3 of pea, might act downstream from or beside the CLE peptides during AON.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
STEM-CELL FATE, L MERR MUTANTS, LOTUS-JAPONICUS, ROOT-NODULE ORGANOGENESIS, AUXIN TRANSPORT REGULATION, FACTOR SIGNAL-TRANSDUCTION, MEDICAGO-TRUNCATULA CONTROLS, RECEPTOR-LIKE KINASE, HYPERNODULATION MUTANT, ARABIDOPSIS-THALIANA
journal title
PLANT PHYSIOLOGY
Plant Physiol.
volume
158
issue
3
pages
1329 - 1341
Web of Science type
Article
Web of Science id
000301280500019
JCR category
PLANT SCIENCES
JCR impact factor
6.555 (2012)
JCR rank
8/193 (2012)
JCR quartile
1 (2012)
ISSN
0032-0889
DOI
10.1104/pp.111.188078
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2087660
handle
http://hdl.handle.net/1854/LU-2087660
date created
2012-04-16 16:00:56
date last changed
2016-12-19 15:42:24
@article{2087660,
  abstract     = {In legumes, the symbiotic nodules are formed as a result of dedifferentiation and reactivation of cortical root cells. A shoot-acting receptor complex, similar to the Arabidopsis (Arabidopsis thaliana) CLAVATA1 (CLV1)/CLV2 receptor, regulating development of the shoot apical meristem, is involved in autoregulation of nodulation (AON), a mechanism that systemically controls nodule number. The targets of CLV1/CLV2 in the shoot apical meristem, the WUSCHEL (WUS)-RELATED HOMEOBOX (WOX) family transcription factors, have been proposed to be important regulators of apical meristem maintenance and to be expressed in apical meristem {\textacutedbl}organizers.{\textacutedbl} Here, we focus on the role of the WOX5 transcription factor upon nodulation in Medicago truncatula and pea (Pisum sativum) that form indeterminate nodules. Analysis of temporal WOX5 expression during nodulation with quantitative reverse transcription-polymerase chain reaction and promoter-reporter fusion revealed that the WOX5 gene was expressed during nodule organogenesis, suggesting that WOX genes are common regulators of cell proliferation in different systems. Furthermore, in nodules of supernodulating mutants, defective in AON, WOX5 expression was higher than that in wild-type nodules. Hence, a conserved WUS/WOX-CLV regulatory system might control cell proliferation and differentiation not only in the root and shoot apical meristems but also in nodule meristems. In addition, the link between nodule-derived CLE peptides activating AON in different legumes and components of the AON system was investigated. We demonstrate that the identified AON component, NODULATION3 of pea, might act downstream from or beside the CLE peptides during AON.},
  author       = {Osipova, Maria A and Mortier, Virginie and Demchenko, Kirill N and Tsyganov, Victor E and Tikhonovich, Igor A and Lutova, Ludmila A and Dolgikh, Elena A and Goormachtig, Sofie},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keyword      = {STEM-CELL FATE,L MERR MUTANTS,LOTUS-JAPONICUS,ROOT-NODULE ORGANOGENESIS,AUXIN TRANSPORT REGULATION,FACTOR SIGNAL-TRANSDUCTION,MEDICAGO-TRUNCATULA CONTROLS,RECEPTOR-LIKE KINASE,HYPERNODULATION MUTANT,ARABIDOPSIS-THALIANA},
  language     = {eng},
  number       = {3},
  pages        = {1329--1341},
  title        = {WUSCHEL-RELATED HOMEOBOX5 gene expression and interaction of CLE peptides with components of the systemic control add two pieces to the puzzle of autoregulation of nodulation},
  url          = {http://dx.doi.org/10.1104/pp.111.188078},
  volume       = {158},
  year         = {2012},
}

Chicago
Osipova, Maria A, Virginie Mortier, Kirill N Demchenko, Victor E Tsyganov, Igor A Tikhonovich, Ludmila A Lutova, Elena A Dolgikh, and Sofie Goormachtig. 2012. “WUSCHEL-RELATED HOMEOBOX5 Gene Expression and Interaction of CLE Peptides with Components of the Systemic Control Add Two Pieces to the Puzzle of Autoregulation of Nodulation.” Plant Physiology 158 (3): 1329–1341.
APA
Osipova, M. A., Mortier, V., Demchenko, K. N., Tsyganov, V. E., Tikhonovich, I. A., Lutova, L. A., Dolgikh, E. A., et al. (2012). WUSCHEL-RELATED HOMEOBOX5 gene expression and interaction of CLE peptides with components of the systemic control add two pieces to the puzzle of autoregulation of nodulation. PLANT PHYSIOLOGY, 158(3), 1329–1341.
Vancouver
1.
Osipova MA, Mortier V, Demchenko KN, Tsyganov VE, Tikhonovich IA, Lutova LA, et al. WUSCHEL-RELATED HOMEOBOX5 gene expression and interaction of CLE peptides with components of the systemic control add two pieces to the puzzle of autoregulation of nodulation. PLANT PHYSIOLOGY. 2012;158(3):1329–41.
MLA
Osipova, Maria A, Virginie Mortier, Kirill N Demchenko, et al. “WUSCHEL-RELATED HOMEOBOX5 Gene Expression and Interaction of CLE Peptides with Components of the Systemic Control Add Two Pieces to the Puzzle of Autoregulation of Nodulation.” PLANT PHYSIOLOGY 158.3 (2012): 1329–1341. Print.