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A radial glia-specific role of RhoA in double cortex formation

Silvia Cappello, Christian RJ Böhringer, Matteo Bergami, Karl-Klaus Conzelmann, Alexander Ghanem, Giulio Srubek Tomassy, Paola Arlotta, Marco Mainardi, Manuela Allegra and Matteo Caleo, et al. (2012) NEURON. 73(5). p.911-924
abstract
The positioning of neurons in the cerebral cortex is of crucial importance for its function as highlighted by the severe consequences of migrational disorders in patients. Here we show that genetic deletion of the small GTPase RhoA in the developing cerebral cortex results in two migrational disorders: subcortical band heterotopia (SBH), a heterotopic cortex underlying the normotopic cortex, and cobblestone lissencephaly, in which neurons protrude beyond layer I at the pial surface of the brain. Surprisingly, Rhoyft(-/-) neurons migrated normally when transplanted into wild-type cerebral cortex, whereas the converse was not the case. Alterations in the radial glia scaffold are demonstrated to cause these migrational defects through destabilization of both the actin and the microtubules cytoskeleton. These data not only demonstrate that RhoA is largely dispensable for migration in neurons but also showed that defects in radial glial cells, rather than neurons, can be sufficient to produce SBH.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CEREBRAL-CORTEX, SERUM RESPONSE FACTOR, OUTER SUBVENTRICULAR ZONE, ABNORMAL NEURONAL MIGRATION, CELL-MIGRATION, VISUAL-CORTEX, PYRAMIDAL NEURONS, PROGENITOR CELLS, CRE RECOMBINASE, IN-VIVO
journal title
NEURON
Neuron
volume
73
issue
5
pages
911 - 924
Web of Science type
Article
Web of Science id
000301558600007
JCR category
NEUROSCIENCES
JCR impact factor
15.766 (2012)
JCR rank
5/251 (2012)
JCR quartile
1 (2012)
ISSN
0896-6273
DOI
10.1016/j.neuron.2011.12.030
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2085494
handle
http://hdl.handle.net/1854/LU-2085494
date created
2012-04-12 16:48:12
date last changed
2012-06-26 14:32:38
@article{2085494,
  abstract     = {The positioning of neurons in the cerebral cortex is of crucial importance for its function as highlighted by the severe consequences of migrational disorders in patients. Here we show that genetic deletion of the small GTPase RhoA in the developing cerebral cortex results in two migrational disorders: subcortical band heterotopia (SBH), a heterotopic cortex underlying the normotopic cortex, and cobblestone lissencephaly, in which neurons protrude beyond layer I at the pial surface of the brain. Surprisingly, Rhoyft(-/-) neurons migrated normally when transplanted into wild-type cerebral cortex, whereas the converse was not the case. Alterations in the radial glia scaffold are demonstrated to cause these migrational defects through destabilization of both the actin and the microtubules cytoskeleton. These data not only demonstrate that RhoA is largely dispensable for migration in neurons but also showed that defects in radial glial cells, rather than neurons, can be sufficient to produce SBH.},
  author       = {Cappello, Silvia and B{\"o}hringer, Christian RJ and Bergami, Matteo and Conzelmann, Karl-Klaus and Ghanem, Alexander and Tomassy, Giulio Srubek and Arlotta, Paola and Mainardi, Marco and Allegra, Manuela and Caleo, Matteo and van Hengel, Jolanda and Brakebusch, Cord and G{\"o}tz, Magdalena},
  issn         = {0896-6273},
  journal      = {NEURON},
  keyword      = {CEREBRAL-CORTEX,SERUM RESPONSE FACTOR,OUTER SUBVENTRICULAR ZONE,ABNORMAL NEURONAL MIGRATION,CELL-MIGRATION,VISUAL-CORTEX,PYRAMIDAL NEURONS,PROGENITOR CELLS,CRE RECOMBINASE,IN-VIVO},
  language     = {eng},
  number       = {5},
  pages        = {911--924},
  title        = {A radial glia-specific role of RhoA in double cortex formation},
  url          = {http://dx.doi.org/10.1016/j.neuron.2011.12.030},
  volume       = {73},
  year         = {2012},
}

Chicago
Cappello, Silvia, Christian RJ Böhringer, Matteo Bergami, Karl-Klaus Conzelmann, Alexander Ghanem, Giulio Srubek Tomassy, Paola Arlotta, et al. 2012. “A Radial Glia-specific Role of RhoA in Double Cortex Formation.” Neuron 73 (5): 911–924.
APA
Cappello, S., Böhringer, C. R., Bergami, M., Conzelmann, K.-K., Ghanem, A., Tomassy, G. S., Arlotta, P., et al. (2012). A radial glia-specific role of RhoA in double cortex formation. NEURON, 73(5), 911–924.
Vancouver
1.
Cappello S, Böhringer CR, Bergami M, Conzelmann K-K, Ghanem A, Tomassy GS, et al. A radial glia-specific role of RhoA in double cortex formation. NEURON. 2012;73(5):911–24.
MLA
Cappello, Silvia, Christian RJ Böhringer, Matteo Bergami, et al. “A Radial Glia-specific Role of RhoA in Double Cortex Formation.” NEURON 73.5 (2012): 911–924. Print.