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Beclin 1: a role in membrane dynamics and beyond

Wirawan, Ellen, Lippens, Saskia UGent, Vanden Berghe, Tom UGent, Romagnoli, Alessandra, Fimia, Gian Maria, Piacentini, Mauro and Vandenabeele, Peter UGent (2012) AUTOPHAGY. 8(1). p.6-17
abstract
Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating PtdIns3KC3-dependent generation of phosphatidylinositol 3-phosphate (PtdIns(3) P) and the subsequent recruitment of additional Atg proteins that orchestrate autophagosome formation. Furthermore, Beclin 1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, tumorigenesis, aging and cell death. Whether all of these processes involve only the autophagy-inducing function of Beclin 1 is now being seriously questioned, because Beclin 1 appears to exercise several non-autophagy functions. Therefore, we should broaden our view of Beclin 1 as a specialized molecule in autophagy to that of a multifunctional protein. The central role of Beclin 1 in multiple signaling events obviously requires tight regulation at multiple levels. Its function is kept in check by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications, and protein-protein interactions. Interestingly, multiple diseases are associated with deficiency or malfunction of Beclin 1, which makes it a potentially valuable target for various therapies, including anticancer treatment. In this review, we focus on Beclin 1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin 1-associated pathologies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
SACCHAROMYCES-CEREVISIAE, Beclin 1, Bcl-2, Atg6, autophagy, 1-DEPENDENT AUTOPHAGY, EMBRYONIC-DEVELOPMENT, REGULATES AUTOPHAGY, CASPASE-MEDIATED CLEAVAGE, AUTOPHAGY-RELATED PROTEIN, TUMOR-SUPPRESSOR, membrane trafficking, PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES, CELL-DEATH, BCL-X-L
journal title
AUTOPHAGY
Autophagy
volume
8
issue
1
pages
6 - 17
Web of Science type
Review
Web of Science id
000300325000002
JCR category
CELL BIOLOGY
JCR impact factor
12.042 (2012)
JCR rank
12/181 (2012)
JCR quartile
1 (2012)
ISSN
1554-8627
DOI
10.4161/auto.8.1.16645
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2085098
handle
http://hdl.handle.net/1854/LU-2085098
date created
2012-04-12 14:59:13
date last changed
2016-12-19 15:44:51
@article{2085098,
  abstract     = {Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating PtdIns3KC3-dependent generation of phosphatidylinositol 3-phosphate (PtdIns(3) P) and the subsequent recruitment of additional Atg proteins that orchestrate autophagosome formation. Furthermore, Beclin 1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, tumorigenesis, aging and cell death. Whether all of these processes involve only the autophagy-inducing function of Beclin 1 is now being seriously questioned, because Beclin 1 appears to exercise several non-autophagy functions. Therefore, we should broaden our view of Beclin 1 as a specialized molecule in autophagy to that of a multifunctional protein. The central role of Beclin 1 in multiple signaling events obviously requires tight regulation at multiple levels. Its function is kept in check by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications, and protein-protein interactions. Interestingly, multiple diseases are associated with deficiency or malfunction of Beclin 1, which makes it a potentially valuable target for various therapies, including anticancer treatment. In this review, we focus on Beclin 1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin 1-associated pathologies.},
  author       = {Wirawan, Ellen and Lippens, Saskia and Vanden Berghe, Tom and Romagnoli, Alessandra and Fimia, Gian Maria and Piacentini, Mauro and Vandenabeele, Peter},
  issn         = {1554-8627},
  journal      = {AUTOPHAGY},
  keyword      = {SACCHAROMYCES-CEREVISIAE,Beclin 1,Bcl-2,Atg6,autophagy,1-DEPENDENT AUTOPHAGY,EMBRYONIC-DEVELOPMENT,REGULATES AUTOPHAGY,CASPASE-MEDIATED CLEAVAGE,AUTOPHAGY-RELATED PROTEIN,TUMOR-SUPPRESSOR,membrane trafficking,PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES,CELL-DEATH,BCL-X-L},
  language     = {eng},
  number       = {1},
  pages        = {6--17},
  title        = {Beclin 1: a role in membrane dynamics and beyond},
  url          = {http://dx.doi.org/10.4161/auto.8.1.16645},
  volume       = {8},
  year         = {2012},
}

Chicago
Wirawan, Ellen, Saskia Lippens, Tom Vanden Berghe, Alessandra Romagnoli, Gian Maria Fimia, Mauro Piacentini, and Peter Vandenabeele. 2012. “Beclin 1: a Role in Membrane Dynamics and Beyond.” Autophagy 8 (1): 6–17.
APA
Wirawan, E., Lippens, S., Vanden Berghe, T., Romagnoli, A., Fimia, G. M., Piacentini, M., & Vandenabeele, P. (2012). Beclin 1: a role in membrane dynamics and beyond. AUTOPHAGY, 8(1), 6–17.
Vancouver
1.
Wirawan E, Lippens S, Vanden Berghe T, Romagnoli A, Fimia GM, Piacentini M, et al. Beclin 1: a role in membrane dynamics and beyond. AUTOPHAGY. 2012;8(1):6–17.
MLA
Wirawan, Ellen, Saskia Lippens, Tom Vanden Berghe, et al. “Beclin 1: a Role in Membrane Dynamics and Beyond.” AUTOPHAGY 8.1 (2012): 6–17. Print.