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Beclin 1: a role in membrane dynamics and beyond

Ellen Wirawan UGent, Saskia Lippens UGent, Tom Vanden Berghe UGent, Alessandra Romagnoli, Gian Maria Fimia, Mauro Piacentini and Peter Vandenabeele UGent (2012) AUTOPHAGY. 8(1). p.6-17
abstract
Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating PtdIns3KC3-dependent generation of phosphatidylinositol 3-phosphate (PtdIns(3) P) and the subsequent recruitment of additional Atg proteins that orchestrate autophagosome formation. Furthermore, Beclin 1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, tumorigenesis, aging and cell death. Whether all of these processes involve only the autophagy-inducing function of Beclin 1 is now being seriously questioned, because Beclin 1 appears to exercise several non-autophagy functions. Therefore, we should broaden our view of Beclin 1 as a specialized molecule in autophagy to that of a multifunctional protein. The central role of Beclin 1 in multiple signaling events obviously requires tight regulation at multiple levels. Its function is kept in check by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications, and protein-protein interactions. Interestingly, multiple diseases are associated with deficiency or malfunction of Beclin 1, which makes it a potentially valuable target for various therapies, including anticancer treatment. In this review, we focus on Beclin 1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin 1-associated pathologies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
SACCHAROMYCES-CEREVISIAE, Beclin 1, Bcl-2, Atg6, autophagy, 1-DEPENDENT AUTOPHAGY, EMBRYONIC-DEVELOPMENT, REGULATES AUTOPHAGY, CASPASE-MEDIATED CLEAVAGE, AUTOPHAGY-RELATED PROTEIN, TUMOR-SUPPRESSOR, membrane trafficking, PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES, CELL-DEATH, BCL-X-L
journal title
AUTOPHAGY
Autophagy
volume
8
issue
1
pages
6 - 17
Web of Science type
Review
Web of Science id
000300325000002
JCR category
CELL BIOLOGY
JCR impact factor
12.042 (2012)
JCR rank
12/181 (2012)
JCR quartile
1 (2012)
ISSN
1554-8627
DOI
10.4161/auto.8.1.16645
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2085098
handle
http://hdl.handle.net/1854/LU-2085098
date created
2012-04-12 14:59:13
date last changed
2014-05-12 10:59:19
@article{2085098,
  abstract     = {Beclin 1 (Atg6) is a well-known key regulator of autophagy. Although Beclin 1 is enzymatically inert, it governs the autophagic process by regulating PtdIns3KC3-dependent generation of phosphatidylinositol 3-phosphate (PtdIns(3) P) and the subsequent recruitment of additional Atg proteins that orchestrate autophagosome formation. Furthermore, Beclin 1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, tumorigenesis, aging and cell death. Whether all of these processes involve only the autophagy-inducing function of Beclin 1 is now being seriously questioned, because Beclin 1 appears to exercise several non-autophagy functions. Therefore, we should broaden our view of Beclin 1 as a specialized molecule in autophagy to that of a multifunctional protein. The central role of Beclin 1 in multiple signaling events obviously requires tight regulation at multiple levels. Its function is kept in check by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications, and protein-protein interactions. Interestingly, multiple diseases are associated with deficiency or malfunction of Beclin 1, which makes it a potentially valuable target for various therapies, including anticancer treatment. In this review, we focus on Beclin 1 as a multifunctional protein, discuss the variety of mechanisms by which it is controlled, and give an overview of Beclin 1-associated pathologies.},
  author       = {Wirawan, Ellen and Lippens, Saskia and Vanden Berghe, Tom and Romagnoli, Alessandra and Fimia, Gian Maria and Piacentini, Mauro and Vandenabeele, Peter},
  issn         = {1554-8627},
  journal      = {AUTOPHAGY},
  keyword      = {SACCHAROMYCES-CEREVISIAE,Beclin 1,Bcl-2,Atg6,autophagy,1-DEPENDENT AUTOPHAGY,EMBRYONIC-DEVELOPMENT,REGULATES AUTOPHAGY,CASPASE-MEDIATED CLEAVAGE,AUTOPHAGY-RELATED PROTEIN,TUMOR-SUPPRESSOR,membrane trafficking,PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES,CELL-DEATH,BCL-X-L},
  language     = {eng},
  number       = {1},
  pages        = {6--17},
  title        = {Beclin 1: a role in membrane dynamics and beyond},
  url          = {http://dx.doi.org/10.4161/auto.8.1.16645},
  volume       = {8},
  year         = {2012},
}

Chicago
Wirawan, Ellen, Saskia Lippens, Tom Vanden Berghe, Alessandra Romagnoli, Gian Maria Fimia, Mauro Piacentini, and Peter Vandenabeele. 2012. “Beclin 1: a Role in Membrane Dynamics and Beyond.” Autophagy 8 (1): 6–17.
APA
Wirawan, E., Lippens, S., Vanden Berghe, T., Romagnoli, A., Fimia, G. M., Piacentini, M., & Vandenabeele, P. (2012). Beclin 1: a role in membrane dynamics and beyond. AUTOPHAGY, 8(1), 6–17.
Vancouver
1.
Wirawan E, Lippens S, Vanden Berghe T, Romagnoli A, Fimia GM, Piacentini M, et al. Beclin 1: a role in membrane dynamics and beyond. AUTOPHAGY. 2012;8(1):6–17.
MLA
Wirawan, Ellen, Saskia Lippens, Tom Vanden Berghe, et al. “Beclin 1: a Role in Membrane Dynamics and Beyond.” AUTOPHAGY 8.1 (2012): 6–17. Print.