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Cardiac changes in horses with atypical myopathy

Tinne Verheyen UGent, Annelies Decloedt UGent, Dominique De Clercq UGent and Gunther van Loon UGent (2012) JOURNAL OF VETERINARY INTERNAL MEDICINE. 26(4). p.1019-1026
abstract
Background : Atypical myopathy (AM) is an acute, fatal rhabdomyolysis in grazing horses that mainly affects skeletal muscles. Postmortem examinations have shown that myocardial damage also occurs. Limited information is available on the effect of AM on cardiac function in affected and surviving horses. Objectives : To describe electrocardiographic and echocardiographic changes associated with AM in the acute stage of the disease and after follow-up. Animals : Horses (n = 12) diagnosed with AM in which cardiac ultrasound examination and ECG recording were available. Methods : All horses underwent clinical examinations, serum biochemistry, electrocardiography, and echocardiography. Four surviving horses underwent the same examinations after 210 weeks. Results : All but 1 horse had increased cardiac troponin I concentrations and 10 horses had ventricular premature depolarizations (VPDs). All horses had prolonged corrected QT (QTcf) intervals on the day of admission and abnormal myocardial wall motion on echocardiography. One of the surviving horses still had VPDs and prolonged QTcf at follow-up after 10 weeks. Conclusions and Clinical Importance : The AM results in characteristic electrocardiographic and echocardiographic changes and may be associated with increased cardiac troponin I concentrations and VPDs. In survivors, abnormal cardiac function still may be found at follow-up after 10 weeks. Additional research in a larger group of horses is necessary to identify the long-term effects of AM on cardiac function.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Cardiac ultrasound, Cardiac dysrhythmia, QT interval, Rhabdomyolysis, Tissue Doppler imaging, LONG-QT SYNDROME, COA DEHYDROGENASE-DEFICIENCY, WALL-MOTION ABNORMALITY, TISSUE DOPPLER, ELECTROLYTE DISORDERS, SPECKLE TRACKING, STRAIN-RATE, INTERVAL, DISPERSION, DISPLACEMENT
journal title
JOURNAL OF VETERINARY INTERNAL MEDICINE
J. Vet. Intern. Med.
volume
26
issue
4
pages
1019 - 1026
Web of Science type
Article
Web of Science id
000306354500020
JCR category
VETERINARY SCIENCES
JCR impact factor
2.064 (2012)
JCR rank
13/142 (2012)
JCR quartile
1 (2012)
ISSN
0891-6640
DOI
10.1111/j.1939-1676.2012.00945.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2082775
handle
http://hdl.handle.net/1854/LU-2082775
date created
2012-04-10 11:54:11
date last changed
2012-09-12 10:20:18
@article{2082775,
  abstract     = {Background : Atypical myopathy (AM) is an acute, fatal rhabdomyolysis in grazing horses that mainly affects skeletal muscles. Postmortem examinations have shown that myocardial damage also occurs. Limited information is available on the effect of AM on cardiac function in affected and surviving horses.
Objectives : To describe electrocardiographic and echocardiographic changes associated with AM in the acute stage of the disease and after follow-up.
Animals : Horses (n = 12) diagnosed with AM in which cardiac ultrasound examination and ECG recording were available.
Methods : All horses underwent clinical examinations, serum biochemistry, electrocardiography, and echocardiography. Four surviving horses underwent the same examinations after 210 weeks.
Results : All but 1 horse had increased cardiac troponin I concentrations and 10 horses had ventricular premature depolarizations (VPDs). All horses had prolonged corrected QT (QTcf) intervals on the day of admission and abnormal myocardial wall motion on echocardiography. One of the surviving horses still had VPDs and prolonged QTcf at follow-up after 10 weeks.
Conclusions and Clinical Importance : The AM results in characteristic electrocardiographic and echocardiographic changes and may be associated with increased cardiac troponin I concentrations and VPDs. In survivors, abnormal cardiac function still may be found at follow-up after 10 weeks. Additional research in a larger group of horses is necessary to identify the long-term effects of AM on cardiac function.},
  author       = {Verheyen, Tinne and Decloedt, Annelies and De Clercq, Dominique and van Loon, Gunther},
  issn         = {0891-6640},
  journal      = {JOURNAL OF VETERINARY INTERNAL MEDICINE},
  keyword      = {Cardiac ultrasound,Cardiac dysrhythmia,QT interval,Rhabdomyolysis,Tissue Doppler imaging,LONG-QT SYNDROME,COA DEHYDROGENASE-DEFICIENCY,WALL-MOTION ABNORMALITY,TISSUE DOPPLER,ELECTROLYTE DISORDERS,SPECKLE TRACKING,STRAIN-RATE,INTERVAL,DISPERSION,DISPLACEMENT},
  language     = {eng},
  number       = {4},
  pages        = {1019--1026},
  title        = {Cardiac changes in horses with atypical myopathy},
  url          = {http://dx.doi.org/10.1111/j.1939-1676.2012.00945.x},
  volume       = {26},
  year         = {2012},
}

Chicago
Verheyen, Tinne, Annelies Decloedt, Dominique De Clercq, and Gunther van Loon. 2012. “Cardiac Changes in Horses with Atypical Myopathy.” Journal of Veterinary Internal Medicine 26 (4): 1019–1026.
APA
Verheyen, T., Decloedt, A., De Clercq, D., & van Loon, G. (2012). Cardiac changes in horses with atypical myopathy. JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(4), 1019–1026.
Vancouver
1.
Verheyen T, Decloedt A, De Clercq D, van Loon G. Cardiac changes in horses with atypical myopathy. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2012;26(4):1019–26.
MLA
Verheyen, Tinne, Annelies Decloedt, Dominique De Clercq, et al. “Cardiac Changes in Horses with Atypical Myopathy.” JOURNAL OF VETERINARY INTERNAL MEDICINE 26.4 (2012): 1019–1026. Print.