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Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report

Jan Spaas (UGent) , Maarten Oosterlinck (UGent) , Sarah Broeckx (UGent) , Michèle Dumoulin (UGent) , Jimmy Saunders (UGent) , Ann Van Soom (UGent) , Frederik Pille (UGent) and Gerlinde Van de Walle (UGent)
Author
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Abstract
A 5-year-old German Warmblood stallion with chronic lameness, attributable to degenerative joint disease (DJD) of the pastern joint unresponsive to medical treatments, was treated with autologous mesenchymal stem cells (MSC). These MSC were isolated from the peripheral blood (PB) of the patient and injected into the pastern joint, at a concentration of 2.5x10(6) cells, twice with an 8-week interval. The positive response to this stem cell treatment was documented by visual gait evaluation as well as objective pressure plate analyses. This paper is the first to describe the use of autologous PB-derived MSC to treat a horse suffering from chronic DJD. The favorable outcome of this single case may stimulate further research on the use of equine peripheral blood as a source of autologous MSC in equine regenerative medicine.
Keywords
STROMAL CELLS, UMBILICAL-CORD BLOOD, BONE-MARROW, THERAPY, TENDON, HORSES, IMPLANTATION, DEFECTS, MODEL

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Citation

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Chicago
Spaas, Jan, Maarten Oosterlinck, Sarah Broeckx, Michèle Dumoulin, Jimmy Saunders, Ann Van Soom, Frederik Pille, and Gerlinde Van de Walle. 2012. “Treatment of Equine Degenerative Joint Disease with Autologous Peripheral Blood-derived Mesenchymal Stem Cells: a Case Report.” Vlaams Diergeneeskundig Tijdschrift 81 (1): 11–15.
APA
Spaas, Jan, Oosterlinck, M., Broeckx, S., Dumoulin, M., Saunders, J., Van Soom, A., Pille, F., et al. (2012). Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 81(1), 11–15.
Vancouver
1.
Spaas J, Oosterlinck M, Broeckx S, Dumoulin M, Saunders J, Van Soom A, et al. Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2012;81(1):11–5.
MLA
Spaas, Jan, Maarten Oosterlinck, Sarah Broeckx, et al. “Treatment of Equine Degenerative Joint Disease with Autologous Peripheral Blood-derived Mesenchymal Stem Cells: a Case Report.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 81.1 (2012): 11–15. Print.
@article{2082164,
  abstract     = {A 5-year-old German Warmblood stallion with chronic lameness, attributable to degenerative joint disease (DJD) of the pastern joint unresponsive to medical treatments, was treated with autologous mesenchymal stem cells (MSC). These MSC were isolated from the peripheral blood (PB) of the patient and injected into the pastern joint, at a concentration of 2.5x10(6) cells, twice with an 8-week interval. The positive response to this stem cell treatment was documented by visual gait evaluation as well as objective pressure plate analyses. This paper is the first to describe the use of autologous PB-derived MSC to treat a horse suffering from chronic DJD. The favorable outcome of this single case may stimulate further research on the use of equine peripheral blood as a source of autologous MSC in equine regenerative medicine.},
  author       = {Spaas, Jan and Oosterlinck, Maarten and Broeckx, Sarah and Dumoulin, Mich{\`e}le and Saunders, Jimmy and Van Soom, Ann and Pille, Frederik and Van de Walle, Gerlinde},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {STROMAL CELLS,UMBILICAL-CORD BLOOD,BONE-MARROW,THERAPY,TENDON,HORSES,IMPLANTATION,DEFECTS,MODEL},
  language     = {eng},
  number       = {1},
  pages        = {11--15},
  title        = {Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report},
  url          = {http://vdt.ugent.be/code/showupload.php?id=697},
  volume       = {81},
  year         = {2012},
}

Web of Science
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