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Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report

Jan Spaas UGent, Maarten Oosterlinck UGent, Sarah Broeckx UGent, Michèle Dumoulin UGent, Jimmy Saunders UGent, Ann Van Soom UGent, Frederik Pille UGent and Gerlinde Van de Walle UGent (2012) VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 81(1). p.11-15
abstract
A 5-year-old German Warmblood stallion with chronic lameness, attributable to degenerative joint disease (DJD) of the pastern joint unresponsive to medical treatments, was treated with autologous mesenchymal stem cells (MSC). These MSC were isolated from the peripheral blood (PB) of the patient and injected into the pastern joint, at a concentration of 2.5x10(6) cells, twice with an 8-week interval. The positive response to this stem cell treatment was documented by visual gait evaluation as well as objective pressure plate analyses. This paper is the first to describe the use of autologous PB-derived MSC to treat a horse suffering from chronic DJD. The favorable outcome of this single case may stimulate further research on the use of equine peripheral blood as a source of autologous MSC in equine regenerative medicine.
Please use this url to cite or link to this publication:
author
organization
alternative title
Een degeneratieve gewrichtsaandoening behandeld met autologe equine mesenchymale stamcellen uit het perifeer bloed
year
type
journalArticle (original)
publication status
published
subject
keyword
STROMAL CELLS, UMBILICAL-CORD BLOOD, BONE-MARROW, THERAPY, TENDON, HORSES, IMPLANTATION, DEFECTS, MODEL
journal title
VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
Vlaams Diergeneesk. Tijdschr.
volume
81
issue
1
pages
11 - 15
Web of Science type
Article
Web of Science id
000301270700002
JCR category
VETERINARY SCIENCES
JCR impact factor
0.361 (2012)
JCR rank
107/142 (2012)
JCR quartile
4 (2012)
ISSN
0303-9021
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
2082164
handle
http://hdl.handle.net/1854/LU-2082164
alternative location
http://vdt.ugent.be/code/showupload.php?id=697
date created
2012-04-06 15:12:28
date last changed
2012-04-06 16:06:47
@article{2082164,
  abstract     = {A 5-year-old German Warmblood stallion with chronic lameness, attributable to degenerative joint disease (DJD) of the pastern joint unresponsive to medical treatments, was treated with autologous mesenchymal stem cells (MSC). These MSC were isolated from the peripheral blood (PB) of the patient and injected into the pastern joint, at a concentration of 2.5x10(6) cells, twice with an 8-week interval. The positive response to this stem cell treatment was documented by visual gait evaluation as well as objective pressure plate analyses. This paper is the first to describe the use of autologous PB-derived MSC to treat a horse suffering from chronic DJD. The favorable outcome of this single case may stimulate further research on the use of equine peripheral blood as a source of autologous MSC in equine regenerative medicine.},
  author       = {Spaas, Jan and Oosterlinck, Maarten and Broeckx, Sarah and Dumoulin, Mich{\`e}le and Saunders, Jimmy and Van Soom, Ann and Pille, Frederik and Van de Walle, Gerlinde},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {STROMAL CELLS,UMBILICAL-CORD BLOOD,BONE-MARROW,THERAPY,TENDON,HORSES,IMPLANTATION,DEFECTS,MODEL},
  language     = {eng},
  number       = {1},
  pages        = {11--15},
  title        = {Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report},
  url          = {http://vdt.ugent.be/code/showupload.php?id=697},
  volume       = {81},
  year         = {2012},
}

Chicago
Spaas, Jan, Maarten Oosterlinck, Sarah Broeckx, Michèle Dumoulin, Jimmy Saunders, Ann Van Soom, Frederik Pille, and Gerlinde Van de Walle. 2012. “Treatment of Equine Degenerative Joint Disease with Autologous Peripheral Blood-derived Mesenchymal Stem Cells: a Case Report.” Vlaams Diergeneeskundig Tijdschrift 81 (1): 11–15.
APA
Spaas, J., Oosterlinck, M., Broeckx, S., Dumoulin, M., Saunders, J., Van Soom, A., Pille, F., et al. (2012). Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 81(1), 11–15.
Vancouver
1.
Spaas J, Oosterlinck M, Broeckx S, Dumoulin M, Saunders J, Van Soom A, et al. Treatment of equine degenerative joint disease with autologous peripheral blood-derived mesenchymal stem cells: a case report. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2012;81(1):11–5.
MLA
Spaas, Jan, Maarten Oosterlinck, Sarah Broeckx, et al. “Treatment of Equine Degenerative Joint Disease with Autologous Peripheral Blood-derived Mesenchymal Stem Cells: a Case Report.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 81.1 (2012): 11–15. Print.