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Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1

(2012) SOFT MATTER. 8(4). p.1146-1154
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Center for nano- and biophotonics (NB-Photonics)
Abstract
Spatial and temporal controlled delivery of growth factors which contribute to efficient repair upon tissue injury or failure remains a major challenge in tissue engineering. In this paper, we evaluated polyelectrolyte multilayer microcapsules to control spatiotemporal release of transforming growth factor-beta 1 (TGF-beta 1). Polyelectrolyte microcapsules were bio-specifically engineered to enhance their ability to bind growth factors. Myofibroblast differentiation and contraction demonstrated that the bioactivity of TGF-beta 1 was not altered upon encapsulation into polyelectrolyte multilayer microcapsules and subsequent incorporation into gelatin based hydrogels. Finally, polyelectrolyte microcapsules were incorporated within a synthetic tissue engineering cryogel scaffold composed of gelatin without affecting the cryogel morphology, cell population capacity or mechanical properties of the scaffold.
Keywords
TRANSFORMING GROWTH-FACTOR-BETA-1, DRUG-DELIVERY, POROUS GELATIN HYDROGELS, FIBROBLAST-GROWTH-FACTOR, MUSCLE ACTIN EXPRESSION, SIZE DEFECT MODEL, FACTOR-DELIVERY, FACTOR-BETA, IN-VIVO, MULTILAYERED CAPSULES

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Citation

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Chicago
De Cock, Liesbeth, Olivier De Wever, Sandra Van Vlierberghe, Els Vanderleyden, Peter Dubruel, Filip De Vos, Chris Vervaet, Jean Paul Remon, and Bruno De Geest. 2012. “Engineered (hep/pARG)2 Polyelectrolyte Capsules for Sustained Release of Bioactive TGF-β1.” Soft Matter 8 (4): 1146–1154.
APA
De Cock, Liesbeth, De Wever, O., Van Vlierberghe, S., Vanderleyden, E., Dubruel, P., De Vos, F., Vervaet, C., et al. (2012). Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1. SOFT MATTER, 8(4), 1146–1154.
Vancouver
1.
De Cock L, De Wever O, Van Vlierberghe S, Vanderleyden E, Dubruel P, De Vos F, et al. Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1. SOFT MATTER. 2012;8(4):1146–54.
MLA
De Cock, Liesbeth, Olivier De Wever, Sandra Van Vlierberghe, et al. “Engineered (hep/pARG)2 Polyelectrolyte Capsules for Sustained Release of Bioactive TGF-β1.” SOFT MATTER 8.4 (2012): 1146–1154. Print.
@article{2078961,
  abstract     = {Spatial and temporal controlled delivery of growth factors which contribute to efficient repair upon tissue injury or failure remains a major challenge in tissue engineering. In this paper, we evaluated polyelectrolyte multilayer microcapsules to control spatiotemporal release of transforming growth factor-beta 1 (TGF-beta 1). Polyelectrolyte microcapsules were bio-specifically engineered to enhance their ability to bind growth factors. Myofibroblast differentiation and contraction demonstrated that the bioactivity of TGF-beta 1 was not altered upon encapsulation into polyelectrolyte multilayer microcapsules and subsequent incorporation into gelatin based hydrogels. Finally, polyelectrolyte microcapsules were incorporated within a synthetic tissue engineering cryogel scaffold composed of gelatin without affecting the cryogel morphology, cell population capacity or mechanical properties of the scaffold.},
  author       = {De Cock, Liesbeth and De Wever, Olivier and Van Vlierberghe, Sandra and Vanderleyden, Els and Dubruel, Peter and De Vos, Filip and Vervaet, Chris and Remon, Jean Paul and De Geest, Bruno},
  issn         = {1744-683X},
  journal      = {SOFT MATTER},
  keyword      = {TRANSFORMING GROWTH-FACTOR-BETA-1,DRUG-DELIVERY,POROUS GELATIN HYDROGELS,FIBROBLAST-GROWTH-FACTOR,MUSCLE ACTIN EXPRESSION,SIZE DEFECT MODEL,FACTOR-DELIVERY,FACTOR-BETA,IN-VIVO,MULTILAYERED CAPSULES},
  language     = {eng},
  number       = {4},
  pages        = {1146--1154},
  title        = {Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-\ensuremath{\beta}1},
  url          = {http://dx.doi.org/10.1039/c1sm06618h},
  volume       = {8},
  year         = {2012},
}

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