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Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1

Liesbeth De Cock, Olivier De Wever UGent, Sandra Van Vlierberghe UGent, Els Vanderleyden, Peter Dubruel UGent, Filip De Vos UGent, Chris Vervaet UGent, Jean Paul Remon UGent and Bruno De Geest UGent (2012) SOFT MATTER. 8(4). p.1146-1154
abstract
Spatial and temporal controlled delivery of growth factors which contribute to efficient repair upon tissue injury or failure remains a major challenge in tissue engineering. In this paper, we evaluated polyelectrolyte multilayer microcapsules to control spatiotemporal release of transforming growth factor-beta 1 (TGF-beta 1). Polyelectrolyte microcapsules were bio-specifically engineered to enhance their ability to bind growth factors. Myofibroblast differentiation and contraction demonstrated that the bioactivity of TGF-beta 1 was not altered upon encapsulation into polyelectrolyte multilayer microcapsules and subsequent incorporation into gelatin based hydrogels. Finally, polyelectrolyte microcapsules were incorporated within a synthetic tissue engineering cryogel scaffold composed of gelatin without affecting the cryogel morphology, cell population capacity or mechanical properties of the scaffold.
Please use this url to cite or link to this publication:
author
organization
alternative title
Engineered (hep/pARG)(2) polyelectrolyte capsules for sustained release of bioactive TGF-beta 1
year
type
journalArticle (original)
publication status
published
subject
keyword
TRANSFORMING GROWTH-FACTOR-BETA-1, DRUG-DELIVERY, POROUS GELATIN HYDROGELS, FIBROBLAST-GROWTH-FACTOR, MUSCLE ACTIN EXPRESSION, SIZE DEFECT MODEL, FACTOR-DELIVERY, FACTOR-BETA, IN-VIVO, MULTILAYERED CAPSULES
journal title
SOFT MATTER
Soft Matter
volume
8
issue
4
pages
1146 - 1154
Web of Science type
Article
Web of Science id
000298754300030
JCR category
POLYMER SCIENCE
JCR impact factor
3.909 (2012)
JCR rank
8/82 (2012)
JCR quartile
1 (2012)
ISSN
1744-683X
DOI
10.1039/c1sm06618h
project
Center for nano- and biophotonics (NB-Photonics)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2078961
handle
http://hdl.handle.net/1854/LU-2078961
date created
2012-04-02 11:27:53
date last changed
2016-12-19 15:45:20
@article{2078961,
  abstract     = {Spatial and temporal controlled delivery of growth factors which contribute to efficient repair upon tissue injury or failure remains a major challenge in tissue engineering. In this paper, we evaluated polyelectrolyte multilayer microcapsules to control spatiotemporal release of transforming growth factor-beta 1 (TGF-beta 1). Polyelectrolyte microcapsules were bio-specifically engineered to enhance their ability to bind growth factors. Myofibroblast differentiation and contraction demonstrated that the bioactivity of TGF-beta 1 was not altered upon encapsulation into polyelectrolyte multilayer microcapsules and subsequent incorporation into gelatin based hydrogels. Finally, polyelectrolyte microcapsules were incorporated within a synthetic tissue engineering cryogel scaffold composed of gelatin without affecting the cryogel morphology, cell population capacity or mechanical properties of the scaffold.},
  author       = {De Cock, Liesbeth and De Wever, Olivier and Van Vlierberghe, Sandra and Vanderleyden, Els and Dubruel, Peter and De Vos, Filip and Vervaet, Chris and Remon, Jean Paul and De Geest, Bruno},
  issn         = {1744-683X},
  journal      = {SOFT MATTER},
  keyword      = {TRANSFORMING GROWTH-FACTOR-BETA-1,DRUG-DELIVERY,POROUS GELATIN HYDROGELS,FIBROBLAST-GROWTH-FACTOR,MUSCLE ACTIN EXPRESSION,SIZE DEFECT MODEL,FACTOR-DELIVERY,FACTOR-BETA,IN-VIVO,MULTILAYERED CAPSULES},
  language     = {eng},
  number       = {4},
  pages        = {1146--1154},
  title        = {Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-\ensuremath{\beta}1},
  url          = {http://dx.doi.org/10.1039/c1sm06618h},
  volume       = {8},
  year         = {2012},
}

Chicago
De Cock, Liesbeth, Olivier De Wever, Sandra Van Vlierberghe, Els Vanderleyden, Peter Dubruel, Filip De Vos, Chris Vervaet, Jean Paul Remon, and Bruno De Geest. 2012. “Engineered (hep/pARG)2 Polyelectrolyte Capsules for Sustained Release of Bioactive TGF-β1.” Soft Matter 8 (4): 1146–1154.
APA
De Cock, Liesbeth, De Wever, O., Van Vlierberghe, S., Vanderleyden, E., Dubruel, P., De Vos, F., Vervaet, C., et al. (2012). Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1. SOFT MATTER, 8(4), 1146–1154.
Vancouver
1.
De Cock L, De Wever O, Van Vlierberghe S, Vanderleyden E, Dubruel P, De Vos F, et al. Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1. SOFT MATTER. 2012;8(4):1146–54.
MLA
De Cock, Liesbeth, Olivier De Wever, Sandra Van Vlierberghe, et al. “Engineered (hep/pARG)2 Polyelectrolyte Capsules for Sustained Release of Bioactive TGF-β1.” SOFT MATTER 8.4 (2012): 1146–1154. Print.