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Gelatin functionalization of biomaterial surfaces: strategies for immobilization and visualization

Sandra Van Vlierberghe UGent, Els Vanderleyden UGent, Veerle Boterberg UGent and Peter Dubruel UGent (2011) POLYMERS. 3(1). p.114-130
abstract
In the present work, the immobilization of gelatin as biopolymer on two types of implantable biomaterials, polyimide and titanium, was compared. Both materials are known for their biocompatibility while lacking cell-interactive behavior. For both materials, a pre-functionalization step was required to enable gelatin immobilization. For the polyimide foils, a reactive succinimidyl ester was introduced first on the surface, followed by covalent grafting of gelatin. For the titanium material, methacrylate groups were first introduced on the Ti surface through a silanization reaction. The applied functionalities enabled the subsequent immobilization of methacrylamide modified gelatin. Both surface modified materials were characterized in depth using atomic force microscopy, static contact angle measurements, confocal fluorescence microscopy, attenuated total reflection infrared spectroscopy and X-ray photo-electron spectroscopy. The results indicated that the strategies elaborated for both material classes are suitable to apply stable gelatin coatings. Interestingly, depending on the material class studied, not all surface analysis techniques are applicable.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
polyimide, gelatin immobilization, titanium, surface characterization
journal title
POLYMERS
Polymers
volume
3
issue
1
pages
114 - 130
Web of Science type
Article
Web of Science id
000208601400007
ISSN
2073-4360
DOI
10.3390/polym3010114
project
Center for nano- and biophotonics (NB-Photonics)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
2078924
handle
http://hdl.handle.net/1854/LU-2078924
date created
2012-04-02 11:19:22
date last changed
2015-08-21 15:26:00
@article{2078924,
  abstract     = {In the present work, the immobilization of gelatin as biopolymer on two types of implantable biomaterials, polyimide and titanium, was compared. Both materials are known for their biocompatibility while lacking cell-interactive behavior. For both materials, a pre-functionalization step was required to enable gelatin immobilization. For the polyimide foils, a reactive succinimidyl ester was introduced first on the surface, followed by covalent grafting of gelatin. For the titanium material, methacrylate groups were first introduced on the Ti surface through a silanization reaction. The applied functionalities enabled the subsequent immobilization of methacrylamide modified gelatin. Both surface modified materials were characterized in depth using atomic force microscopy, static contact angle measurements, confocal fluorescence microscopy, attenuated total reflection infrared spectroscopy and X-ray photo-electron spectroscopy. The results indicated that the strategies elaborated for both material classes are suitable to apply stable gelatin coatings. Interestingly, depending on the material class studied, not all surface analysis techniques are applicable.},
  author       = {Van Vlierberghe, Sandra and Vanderleyden, Els and Boterberg, Veerle and Dubruel, Peter},
  issn         = {2073-4360},
  journal      = {POLYMERS},
  keyword      = {polyimide,gelatin immobilization,titanium,surface characterization},
  language     = {eng},
  number       = {1},
  pages        = {114--130},
  title        = {Gelatin functionalization of biomaterial surfaces: strategies for immobilization and visualization},
  url          = {http://dx.doi.org/10.3390/polym3010114},
  volume       = {3},
  year         = {2011},
}

Chicago
Van Vlierberghe, Sandra, Els Vanderleyden, Veerle Boterberg, and Peter Dubruel. 2011. “Gelatin Functionalization of Biomaterial Surfaces: Strategies for Immobilization and Visualization.” Polymers 3 (1): 114–130.
APA
Van Vlierberghe, Sandra, Vanderleyden, E., Boterberg, V., & Dubruel, P. (2011). Gelatin functionalization of biomaterial surfaces: strategies for immobilization and visualization. POLYMERS, 3(1), 114–130.
Vancouver
1.
Van Vlierberghe S, Vanderleyden E, Boterberg V, Dubruel P. Gelatin functionalization of biomaterial surfaces: strategies for immobilization and visualization. POLYMERS. 2011;3(1):114–30.
MLA
Van Vlierberghe, Sandra, Els Vanderleyden, Veerle Boterberg, et al. “Gelatin Functionalization of Biomaterial Surfaces: Strategies for Immobilization and Visualization.” POLYMERS 3.1 (2011): 114–130. Print.