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Excellent survival after liver transplantation for isolated polycystic liver disease: an European Liver Transplant Registry study

Loes van Keimpema, Frederik Nevens, Rene Adam, Robert J Porte, Panagiotis Fikatas, Thomas Becker, Preben Kirkegaard, Herold J Metselaar, Joost PH Drenth, the European Liver and Intestine Transplant Association (ELITA), et al. (2011) TRANSPLANT INTERNATIONAL. 24(12). p.1239-1245
abstract
Patients with end-stage isolated polycystic liver disease (PCLD) suffer from incapacitating symptoms because of very large liver volumes. Liver transplantation (LT) is the only curative option. This study assesses the feasibility of LT in PCLD. We used the European Liver Transplant Registry (ELTR) database to extract demographics and outcomes of 58 PCLD patients. We used Kaplan-Meier survival analysis for survival rates. Severe abdominal pain (75%) was the most prominent symptom, while portal hypertension (35%) was the most common complication in PCLD. The explantation of the polycystic liver was extremely difficult in 38% of patients, because of presence of adhesions from prior therapy (17%). Karnofsky score following LT was 90%. The 1- and 5-year graft survival rate was 94.3% and 87.5%, while patient survival rate was 94.8% and 92.3%, respectively. Survival rates after LT for PCLD are good.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FENESTRATION, MANAGEMENT, liver cyst, polycystic liver disease, liver transplantation, KIDNEY-TRANSPLANTATION, treatment, VOLUME, CYSTS
journal title
TRANSPLANT INTERNATIONAL
Transpl. Int.
volume
24
issue
12
pages
1239 - 1245
Web of Science type
Article
Web of Science id
000297580400018
JCR category
SURGERY
JCR impact factor
2.921 (2011)
JCR rank
26/198 (2011)
JCR quartile
1 (2011)
ISSN
0934-0874
DOI
10.1111/j.1432-2277.2011.01360.x
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2077401
handle
http://hdl.handle.net/1854/LU-2077401
date created
2012-03-30 07:51:23
date last changed
2016-12-19 15:44:51
@article{2077401,
  abstract     = {Patients with end-stage isolated polycystic liver disease (PCLD) suffer from incapacitating symptoms because of very large liver volumes. Liver transplantation (LT) is the only curative option. This study assesses the feasibility of LT in PCLD. We used the European Liver Transplant Registry (ELTR) database to extract demographics and outcomes of 58 PCLD patients. We used Kaplan-Meier survival analysis for survival rates. Severe abdominal pain (75\%) was the most prominent symptom, while portal hypertension (35\%) was the most common complication in PCLD. The explantation of the polycystic liver was extremely difficult in 38\% of patients, because of presence of adhesions from prior therapy (17\%). Karnofsky score following LT was 90\%. The 1- and 5-year graft survival rate was 94.3\% and 87.5\%, while patient survival rate was 94.8\% and 92.3\%, respectively. Survival rates after LT for PCLD are good.},
  author       = {van Keimpema, Loes and Nevens, Frederik and Adam, Rene and Porte, Robert J and Fikatas, Panagiotis and Becker, Thomas and Kirkegaard, Preben and Metselaar, Herold J and Drenth, Joost PH and European Liver and Intestine Transplant Association (ELITA), the and Van Vlierberghe, Hans},
  issn         = {0934-0874},
  journal      = {TRANSPLANT INTERNATIONAL},
  keyword      = {FENESTRATION,MANAGEMENT,liver cyst,polycystic liver disease,liver transplantation,KIDNEY-TRANSPLANTATION,treatment,VOLUME,CYSTS},
  language     = {eng},
  number       = {12},
  pages        = {1239--1245},
  title        = {Excellent survival after liver transplantation for isolated polycystic liver disease: an European Liver Transplant Registry study},
  url          = {http://dx.doi.org/10.1111/j.1432-2277.2011.01360.x},
  volume       = {24},
  year         = {2011},
}

Chicago
van Keimpema, Loes, Frederik Nevens, Rene Adam, Robert J Porte, Panagiotis Fikatas, Thomas Becker, Preben Kirkegaard, et al. 2011. “Excellent Survival After Liver Transplantation for Isolated Polycystic Liver Disease: An European Liver Transplant Registry Study.” Transplant International 24 (12): 1239–1245.
APA
van Keimpema, L., Nevens, F., Adam, R., Porte, R. J., Fikatas, P., Becker, T., Kirkegaard, P., et al. (2011). Excellent survival after liver transplantation for isolated polycystic liver disease: an European Liver Transplant Registry study. TRANSPLANT INTERNATIONAL, 24(12), 1239–1245.
Vancouver
1.
van Keimpema L, Nevens F, Adam R, Porte RJ, Fikatas P, Becker T, et al. Excellent survival after liver transplantation for isolated polycystic liver disease: an European Liver Transplant Registry study. TRANSPLANT INTERNATIONAL. 2011;24(12):1239–45.
MLA
van Keimpema, Loes, Frederik Nevens, Rene Adam, et al. “Excellent Survival After Liver Transplantation for Isolated Polycystic Liver Disease: An European Liver Transplant Registry Study.” TRANSPLANT INTERNATIONAL 24.12 (2011): 1239–1245. Print.