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Invasiveness of primary and secondary brain tumors in vitro correlated with clinical results

Leo De Ridder and Luc Calliauw (1992) NEUROSURGERY. 31(6). p.1043-1048
abstract
ONE HUNDRED FIFTY-ONE tumor fragments were collected in the neurosurgical operating amphitheater immediately after removal. Small tumor fragments were transferred into culture flasks and cultured until a confluent monolayer was formed by the outgrowing cells. Flaps of these cell monolayers were mechanically scraped from the culture flasks and confronted with embryonic chick heart tissue in vitro. The evolution of the confrontations was followed for a week. Histological analysis of the confrontations demonstrated three different morphological patterns of interaction between the heart tissue and the tumor-derived cells: 1) progressive engulfment of the tumor-derived cells by the heart tissue (Type I), 2) survival of both the heart tissue and the tumor-derived cells (Type II), and 3) progressive replacement of the heart tissue by tumor-derived cells (Type III). The replacement of the heart tissue by tumor-derived cells was only observed in cells originating from malignant tumors that were invasive and metastatic in vivo. Thus, invasiveness in confrontation culture is correlated with malignancy in vivo.
Please use this url to cite or link to this publication:
author
organization
alternative title
Invasiveness of primary and secondary brain tumors invitro correlated with clinical results
year
type
journalArticle (original)
publication status
published
subject
keyword
CELL CULTURE, BRAIN NEOPLASM, GLIOMA, INVASIVENESS, MALIGNANCY, GLIOMA-CELLS, INVASION, CULTURE, GROWTH
journal title
NEUROSURGERY
Neurosurgery
volume
31
issue
6
pages
1043 - 1048
Web of Science type
Article
ISSN
0148-396X
language
English
UGent publication?
yes
classification
A1
id
207561
handle
http://hdl.handle.net/1854/LU-207561
alternative location
http://journals.lww.com/neurosurgery/Abstract/1992/12000/Invasiveness_of_Primary_and_Secondary_Brain_Tumors.9.aspx
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:39:15
@article{207561,
  abstract     = {ONE HUNDRED FIFTY-ONE tumor fragments were collected in the neurosurgical operating amphitheater immediately after removal. Small tumor fragments were transferred into culture flasks and cultured until a confluent monolayer was formed by the outgrowing cells. Flaps of these cell monolayers were mechanically scraped from the culture flasks and confronted with embryonic chick heart tissue in vitro. The evolution of the confrontations was followed for a week. Histological analysis of the confrontations demonstrated three different morphological patterns of interaction between the heart tissue and the tumor-derived cells: 1) progressive engulfment of the tumor-derived cells by the heart tissue (Type I), 2) survival of both the heart tissue and the tumor-derived cells (Type II), and 3) progressive replacement of the heart tissue by tumor-derived cells (Type III). The replacement of the heart tissue by tumor-derived cells was only observed in cells originating from malignant tumors that were invasive and metastatic in vivo. Thus, invasiveness in confrontation culture is correlated with malignancy in vivo.},
  author       = {De Ridder, Leo and Calliauw, Luc},
  issn         = {0148-396X},
  journal      = {NEUROSURGERY},
  keyword      = {CELL CULTURE,BRAIN NEOPLASM,GLIOMA,INVASIVENESS,MALIGNANCY,GLIOMA-CELLS,INVASION,CULTURE,GROWTH},
  language     = {eng},
  number       = {6},
  pages        = {1043--1048},
  title        = {Invasiveness of primary and secondary brain tumors in vitro correlated with clinical results},
  url          = {http://journals.lww.com/neurosurgery/Abstract/1992/12000/Invasiveness\_of\_Primary\_and\_Secondary\_Brain\_Tumors.9.aspx},
  volume       = {31},
  year         = {1992},
}

Chicago
De Ridder, Leo, and Luc Calliauw. 1992. “Invasiveness of Primary and Secondary Brain Tumors in Vitro Correlated with Clinical Results.” Neurosurgery 31 (6): 1043–1048.
APA
De Ridder, Leo, & Calliauw, L. (1992). Invasiveness of primary and secondary brain tumors in vitro correlated with clinical results. NEUROSURGERY, 31(6), 1043–1048.
Vancouver
1.
De Ridder L, Calliauw L. Invasiveness of primary and secondary brain tumors in vitro correlated with clinical results. NEUROSURGERY. 1992;31(6):1043–8.
MLA
De Ridder, Leo, and Luc Calliauw. “Invasiveness of Primary and Secondary Brain Tumors in Vitro Correlated with Clinical Results.” NEUROSURGERY 31.6 (1992): 1043–1048. Print.