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Influence of age on responsiveness of rat gastric fundus to agonists and to stimulation of intrinsic nerves

Geert JM Smits UGent and Romain Lefebvre UGent (1992) EUROPEAN JOURNAL OF PHARMACOLOGY. 223(1). p.97-102
abstract
The contractile effect of methacholine, prostaglandin F2alpha (PGF2alpha) and electrical stimulation of cholinergic neurones, and the relaxant effect of nitric oxide (NO), vasoactive intestinal polypeptide (VIP) and electrical stimulation of inhibitory non-adrenergic non-cholinergic (NANC) neurones were studied in longitudinal smooth muscle strips of the gastric fundus of young (3 months), adult (12 months) and old (24 months) male Wistar rats. The contractile responses to methacholine and to electrical stimulation of cholinergic neurones were not significantly different between the three age groups. The responses to PGF2alpha were significantly more pronounced in young than in adult and old rats. The relaxant response to electrical stimulation of NANC neurones with a cumulative increase in frequency showed a decreased response in old rats at the higher stimulation frequencies. This was mimicked by a decreased response to VIP, suggesting that there is a decrease in muscular sensitivity to VIP rather than an impaired capacity to VIP release with increasing age. The relaxant response to electrical stimulation of NANC neurones with short trains was similar in the three age groups, while the sensitivity to exogenous NO increased with age. The latter might be a compensatory mechanism for a decrease in stimulation-induced NO release with age.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
AGING, VIP (VASOACTIVE INTESTINAL POLYPEPTIDE), STOMACH (RAT), NONADRENERGIC, NONCHOLINERGIC (NANC), NITRIC OXIDE (NO), CHOLINERGIC NEURONS, VASOACTIVE INTESTINAL POLYPEPTIDE, NITRIC-OXIDE, TRANSMISSION, INNERVATION
journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
Eur. J. Pharmacol.
volume
223
issue
1
pages
97 - 102
Web of Science type
Article
ISSN
0014-2999
DOI
10.1016/0014-2999(92)90823-M
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
207295
handle
http://hdl.handle.net/1854/LU-207295
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:38:01
@article{207295,
  abstract     = {The contractile effect of methacholine, prostaglandin F2alpha (PGF2alpha) and electrical stimulation of cholinergic neurones, and the relaxant effect of nitric oxide (NO), vasoactive intestinal polypeptide (VIP) and electrical stimulation of inhibitory non-adrenergic non-cholinergic (NANC) neurones were studied in longitudinal smooth muscle strips of the gastric fundus of young (3 months), adult (12 months) and old (24 months) male Wistar rats. The contractile responses to methacholine and to electrical stimulation of cholinergic neurones were not significantly different between the three age groups. The responses to PGF2alpha were significantly more pronounced in young than in adult and old rats. The relaxant response to electrical stimulation of NANC neurones with a cumulative increase in frequency showed a decreased response in old rats at the higher stimulation frequencies. This was mimicked by a decreased response to VIP, suggesting that there is a decrease in muscular sensitivity to VIP rather than an impaired capacity to VIP release with increasing age. The relaxant response to electrical stimulation of NANC neurones with short trains was similar in the three age groups, while the sensitivity to exogenous NO increased with age. The latter might be a compensatory mechanism for a decrease in stimulation-induced NO release with age.},
  author       = {Smits, Geert JM and Lefebvre, Romain},
  issn         = {0014-2999},
  journal      = {EUROPEAN JOURNAL OF PHARMACOLOGY},
  keyword      = {AGING,VIP (VASOACTIVE INTESTINAL POLYPEPTIDE),STOMACH (RAT),NONADRENERGIC,NONCHOLINERGIC (NANC),NITRIC OXIDE (NO),CHOLINERGIC NEURONS,VASOACTIVE INTESTINAL POLYPEPTIDE,NITRIC-OXIDE,TRANSMISSION,INNERVATION},
  language     = {eng},
  number       = {1},
  pages        = {97--102},
  title        = {Influence of age on responsiveness of rat gastric fundus to agonists and to stimulation of intrinsic nerves},
  url          = {http://dx.doi.org/10.1016/0014-2999(92)90823-M},
  volume       = {223},
  year         = {1992},
}

Chicago
Smits, Geert JM, and Romain Lefebvre. 1992. “Influence of Age on Responsiveness of Rat Gastric Fundus to Agonists and to Stimulation of Intrinsic Nerves.” European Journal of Pharmacology 223 (1): 97–102.
APA
Smits, G. J., & Lefebvre, R. (1992). Influence of age on responsiveness of rat gastric fundus to agonists and to stimulation of intrinsic nerves. EUROPEAN JOURNAL OF PHARMACOLOGY, 223(1), 97–102.
Vancouver
1.
Smits GJ, Lefebvre R. Influence of age on responsiveness of rat gastric fundus to agonists and to stimulation of intrinsic nerves. EUROPEAN JOURNAL OF PHARMACOLOGY. 1992;223(1):97–102.
MLA
Smits, Geert JM, and Romain Lefebvre. “Influence of Age on Responsiveness of Rat Gastric Fundus to Agonists and to Stimulation of Intrinsic Nerves.” EUROPEAN JOURNAL OF PHARMACOLOGY 223.1 (1992): 97–102. Print.