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Skin organ culture model to test the toxicity of polyoxyethylene networks

Hilde Beele UGent, Hubert Thierens UGent, Robert Deveux, Eric Goethals UGent and Leo De Ridder (1992) BIOMATERIALS. 13(14). p.1031-1037
abstract
Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin and embryonic chicken skin. A rapid toxic effect was observed, especially with the urethane-linked network. Enzymatical degradation of the network by enzymes in the culture medium might be responsible for the formation of toxic metabolites. Testing of related chemical compounds in our in vitro assay suggested that the formation of a silane group with an amino terminal is most likely to be responsible for the toxic effects observed.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EMBRYONIC CHICKEN SKIN, WOUND DRESSINGS, BIOCOMPATIBILITY, POLYOXYETHYLENE, TOXICITY, INVITRO
journal title
BIOMATERIALS
Biomaterials
volume
13
issue
14
pages
1031 - 1037
Web of Science type
Article
ISSN
0142-9612
DOI
10.1016/0142-9612(92)90155-H
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
207276
handle
http://hdl.handle.net/1854/LU-207276
date created
2004-01-14 13:42:00
date last changed
2016-12-19 15:38:01
@article{207276,
  abstract     = {Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin and embryonic chicken skin. A rapid toxic effect was observed, especially with the urethane-linked network. Enzymatical degradation of the network by enzymes in the culture medium might be responsible for the formation of toxic metabolites. Testing of related chemical compounds in our in vitro assay suggested that the formation of a silane group with an amino terminal is most likely to be responsible for the toxic effects observed.},
  author       = {Beele, Hilde and Thierens, Hubert and Deveux, Robert and Goethals, Eric and De Ridder, Leo},
  issn         = {0142-9612},
  journal      = {BIOMATERIALS},
  keyword      = {EMBRYONIC CHICKEN SKIN,WOUND DRESSINGS,BIOCOMPATIBILITY,POLYOXYETHYLENE,TOXICITY,INVITRO},
  language     = {eng},
  number       = {14},
  pages        = {1031--1037},
  title        = {Skin organ culture model to test the toxicity of polyoxyethylene networks},
  url          = {http://dx.doi.org/10.1016/0142-9612(92)90155-H},
  volume       = {13},
  year         = {1992},
}

Chicago
Beele, Hilde, Hubert Thierens, Robert Deveux, Eric Goethals, and Leo De Ridder. 1992. “Skin Organ Culture Model to Test the Toxicity of Polyoxyethylene Networks.” Biomaterials 13 (14): 1031–1037.
APA
Beele, H., Thierens, H., Deveux, R., Goethals, E., & De Ridder, L. (1992). Skin organ culture model to test the toxicity of polyoxyethylene networks. BIOMATERIALS, 13(14), 1031–1037.
Vancouver
1.
Beele H, Thierens H, Deveux R, Goethals E, De Ridder L. Skin organ culture model to test the toxicity of polyoxyethylene networks. BIOMATERIALS. 1992;13(14):1031–7.
MLA
Beele, Hilde, Hubert Thierens, Robert Deveux, et al. “Skin Organ Culture Model to Test the Toxicity of Polyoxyethylene Networks.” BIOMATERIALS 13.14 (1992): 1031–1037. Print.