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Skin organ culture model to test the toxicity of polyoxyethylene networks

Hilde Beele (UGent) , Hubert Thierens (UGent) , Robert Deveux, Eric Goethals (UGent) and Leo De Ridder (UGent)
(1992) BIOMATERIALS. 13(14). p.1031-1037
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Abstract
Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin and embryonic chicken skin. A rapid toxic effect was observed, especially with the urethane-linked network. Enzymatical degradation of the network by enzymes in the culture medium might be responsible for the formation of toxic metabolites. Testing of related chemical compounds in our in vitro assay suggested that the formation of a silane group with an amino terminal is most likely to be responsible for the toxic effects observed.
Keywords
EMBRYONIC CHICKEN SKIN, WOUND DRESSINGS, BIOCOMPATIBILITY, POLYOXYETHYLENE, TOXICITY, INVITRO

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Citation

Please use this url to cite or link to this publication:

Chicago
Beele, Hilde, Hubert Thierens, Robert Deveux, Eric Goethals, and Leo De Ridder. 1992. “Skin Organ Culture Model to Test the Toxicity of Polyoxyethylene Networks.” Biomaterials 13 (14): 1031–1037.
APA
Beele, H., Thierens, H., Deveux, R., Goethals, E., & De Ridder, L. (1992). Skin organ culture model to test the toxicity of polyoxyethylene networks. BIOMATERIALS, 13(14), 1031–1037.
Vancouver
1.
Beele H, Thierens H, Deveux R, Goethals E, De Ridder L. Skin organ culture model to test the toxicity of polyoxyethylene networks. BIOMATERIALS. 1992;13(14):1031–7.
MLA
Beele, Hilde, Hubert Thierens, Robert Deveux, et al. “Skin Organ Culture Model to Test the Toxicity of Polyoxyethylene Networks.” BIOMATERIALS 13.14 (1992): 1031–1037. Print.
@article{207276,
  abstract     = {Films of polyoxyethylene network were prepared from two types of triethoxysilane-terminated prepolymers. In this way, films of polyoxyethylene network with possible applications in the biomedical field could be made easier. To test their biocompatibility, these networks were added to organ cultures of adult human skin and embryonic chicken skin. A rapid toxic effect was observed, especially with the urethane-linked network. Enzymatical degradation of the network by enzymes in the culture medium might be responsible for the formation of toxic metabolites. Testing of related chemical compounds in our in vitro assay suggested that the formation of a silane group with an amino terminal is most likely to be responsible for the toxic effects observed.},
  author       = {Beele, Hilde and Thierens, Hubert and Deveux, Robert and Goethals, Eric and De Ridder, Leo},
  issn         = {0142-9612},
  journal      = {BIOMATERIALS},
  keyword      = {EMBRYONIC CHICKEN SKIN,WOUND DRESSINGS,BIOCOMPATIBILITY,POLYOXYETHYLENE,TOXICITY,INVITRO},
  language     = {eng},
  number       = {14},
  pages        = {1031--1037},
  title        = {Skin organ culture model to test the toxicity of polyoxyethylene networks},
  url          = {http://dx.doi.org/10.1016/0142-9612(92)90155-H},
  volume       = {13},
  year         = {1992},
}

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