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Impact of white matter lesions on physical functioning and fall risk in older people a systematic review

Jacqueline JJ Zheng, Kim Delbaere UGent, Jacqueline CT Close, Perminder S Sachdev and Stephen R Lord (2011) STROKE. 42(7). p.2086-2090
abstract
Background and Purpose-White matter lesions (WMLs) are common findings on neuroimaging in older people. This review systematically evaluates the published literature on the associations between WMLs and balance, gait, mobility, and falls in older people. Methods-Studies were identified with searches of the MEDLINE databases. Articles reporting associations between WMLs and balance, gait, mobility, and falls in older people in cross-sectional and longitudinal studies were included. Results-Thirty-one articles reporting data from 19 studies met the inclusion criteria. There were consistent findings from both cross-sectional and longitudinal studies indicating greater WML volumes are associated with impaired balance, slower gait, and reduced mobility. Most studies addressing regional WML distributions have reported that WMHs in the frontal lobe and periventricular regions show the strongest relationships with balance, gait, and mobility impairments. In relation to falls, a threshold effect was apparent in that only those with severe WML volumes were found to be at increased risk of falling. Conclusions-The findings of this systematic review indicate that WMLs are common and are significantly associated with impaired balance, gait, mobility, and falls in older people. In many studies, however, impaired mobility and increased fall risk are only evident in people who have the most severe degree of WMLs. (Stroke. 2011; 42: 2086-2090.)
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
brain, aged and accidental falls, LEUKOARAIOSIS, ABNORMALITIES, HYPERINTENSITIES, ADULTS, GAIT, FOLLOW-UP, ELDERLY-PATIENTS, POSTURAL STABILITY, CARDIOVASCULAR HEALTH, MILD COGNITIVE IMPAIRMENT, gait, magnetic resonance imaging (MRI), physical function, white matter lesions
journal title
STROKE
Stroke
volume
42
issue
7
pages
2086 - 2090
Web of Science type
Review
Web of Science id
000292090900062
JCR category
CLINICAL NEUROLOGY
JCR impact factor
5.729 (2011)
JCR rank
14/190 (2011)
JCR quartile
1 (2011)
ISSN
0039-2499
DOI
10.1161/STROKEAHA.110.610360
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2072047
handle
http://hdl.handle.net/1854/LU-2072047
date created
2012-03-21 16:43:19
date last changed
2015-06-17 09:59:51
@article{2072047,
  abstract     = {Background and Purpose-White matter lesions (WMLs) are common findings on neuroimaging in older people. This review systematically evaluates the published literature on the associations between WMLs and balance, gait, mobility, and falls in older people. Methods-Studies were identified with searches of the MEDLINE databases. Articles reporting associations between WMLs and balance, gait, mobility, and falls in older people in cross-sectional and longitudinal studies were included. Results-Thirty-one articles reporting data from 19 studies met the inclusion criteria. There were consistent findings from both cross-sectional and longitudinal studies indicating greater WML volumes are associated with impaired balance, slower gait, and reduced mobility. Most studies addressing regional WML distributions have reported that WMHs in the frontal lobe and periventricular regions show the strongest relationships with balance, gait, and mobility impairments. In relation to falls, a threshold effect was apparent in that only those with severe WML volumes were found to be at increased risk of falling. Conclusions-The findings of this systematic review indicate that WMLs are common and are significantly associated with impaired balance, gait, mobility, and falls in older people. In many studies, however, impaired mobility and increased fall risk are only evident in people who have the most severe degree of WMLs. (Stroke. 2011; 42: 2086-2090.)},
  author       = {Zheng, Jacqueline JJ and Delbaere, Kim and Close, Jacqueline CT and Sachdev, Perminder S and Lord, Stephen R},
  issn         = {0039-2499},
  journal      = {STROKE},
  keyword      = {brain,aged and accidental falls,LEUKOARAIOSIS,ABNORMALITIES,HYPERINTENSITIES,ADULTS,GAIT,FOLLOW-UP,ELDERLY-PATIENTS,POSTURAL STABILITY,CARDIOVASCULAR HEALTH,MILD COGNITIVE IMPAIRMENT,gait,magnetic resonance imaging (MRI),physical function,white matter lesions},
  language     = {eng},
  number       = {7},
  pages        = {2086--2090},
  title        = {Impact of white matter lesions on physical functioning and fall risk in older people a systematic review},
  url          = {http://dx.doi.org/10.1161/STROKEAHA.110.610360},
  volume       = {42},
  year         = {2011},
}

Chicago
Zheng, Jacqueline JJ, Kim Delbaere, Jacqueline CT Close, Perminder S Sachdev, and Stephen R Lord. 2011. “Impact of White Matter Lesions on Physical Functioning and Fall Risk in Older People a Systematic Review.” Stroke 42 (7): 2086–2090.
APA
Zheng, Jacqueline JJ, Delbaere, K., Close, J. C., Sachdev, P. S., & Lord, S. R. (2011). Impact of white matter lesions on physical functioning and fall risk in older people a systematic review. STROKE, 42(7), 2086–2090.
Vancouver
1.
Zheng JJ, Delbaere K, Close JC, Sachdev PS, Lord SR. Impact of white matter lesions on physical functioning and fall risk in older people a systematic review. STROKE. 2011;42(7):2086–90.
MLA
Zheng, Jacqueline JJ, Kim Delbaere, Jacqueline CT Close, et al. “Impact of White Matter Lesions on Physical Functioning and Fall Risk in Older People a Systematic Review.” STROKE 42.7 (2011): 2086–2090. Print.