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Identifying a distinctive familial frequency band in reaction time fluctuations in ADHD

(2011) NEUROPSYCHOLOGY. 25(6). p.711-719
Author
Organization
Abstract
Objective: Patients with ADHD are typically more variable in their reaction times (RT) than control children. Signal processing analyses have shown that time series RT data of children with ADHD have a distinctive low frequency periodic structure suggestive of a pattern of occasional spontaneous performance lapses. Here we use a fine-grained analysis of spectral power across a broader frequency range to differentiate the periodic qualities of ADHD time series RT data from (a) 1/frequency noise, and (b) control performance. We also assess the familiality of these frequencies by using a proband-sibling design. Method: Seventy-one children with ADHD, one of their siblings, and 50 control participants completed a simple RT task. Power across the RI frequency spectrum was calculated. The frequencies significantly differentiating the two groups were identified. Familiality was assessed in two ways: first, by comparing probands with their unaffected siblings and controls, and, second, by investigating the siblings of neuropsychologically impaired and unimpaired children with ADHD. Results: Analyses converged to highlight the potential importance of the .20-.26 Hz band in differentiating the periodic structure of ADHD RT time series data from both 1/frequency noise and control performance. This frequency band also showed the strongest evidence of familiality. Conclusions: RT performance of children with ADHD had a distinctive periodic structure. The band identified as most differentiating and familial was at a higher frequency than in most previous reports. This highlights the importance of employing tasks with faster interstimulus intervals that will allow a larger portion of the frequency spectrum to be examined.
Keywords
DEFICIT HYPERACTIVITY DISORDER, endophenotype, attentional lapses, CHILDREN, INHIBITION, reaction time variability, DEFAULT-MODE, DELAY AVERSION, BRAIN ACTIVITY, INTRAINDIVIDUAL VARIABILITY, RESPONSE VARIABILITY, INTRA-SUBJECT VARIABILITY, attention-deficit/hyperactivity disorder, low frequency, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

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Citation

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MLA
Helps, Suzannah K., et al. “Identifying a Distinctive Familial Frequency Band in Reaction Time Fluctuations in ADHD.” NEUROPSYCHOLOGY, vol. 25, no. 6, 2011, pp. 711–19, doi:10.1037/a0024479.
APA
Helps, S. K., Broyd, S. J., Bitsakou, P., & Barke, E. (2011). Identifying a distinctive familial frequency band in reaction time fluctuations in ADHD. NEUROPSYCHOLOGY, 25(6), 711–719. https://doi.org/10.1037/a0024479
Chicago author-date
Helps, Suzannah K, Samantha J Broyd, Paraskevi Bitsakou, and Edmund Barke. 2011. “Identifying a Distinctive Familial Frequency Band in Reaction Time Fluctuations in ADHD.” NEUROPSYCHOLOGY 25 (6): 711–19. https://doi.org/10.1037/a0024479.
Chicago author-date (all authors)
Helps, Suzannah K, Samantha J Broyd, Paraskevi Bitsakou, and Edmund Barke. 2011. “Identifying a Distinctive Familial Frequency Band in Reaction Time Fluctuations in ADHD.” NEUROPSYCHOLOGY 25 (6): 711–719. doi:10.1037/a0024479.
Vancouver
1.
Helps SK, Broyd SJ, Bitsakou P, Barke E. Identifying a distinctive familial frequency band in reaction time fluctuations in ADHD. NEUROPSYCHOLOGY. 2011;25(6):711–9.
IEEE
[1]
S. K. Helps, S. J. Broyd, P. Bitsakou, and E. Barke, “Identifying a distinctive familial frequency band in reaction time fluctuations in ADHD,” NEUROPSYCHOLOGY, vol. 25, no. 6, pp. 711–719, 2011.
@article{2071886,
  abstract     = {{Objective: Patients with ADHD are typically more variable in their reaction times (RT) than control children. Signal processing analyses have shown that time series RT data of children with ADHD have a distinctive low frequency periodic structure suggestive of a pattern of occasional spontaneous performance lapses. Here we use a fine-grained analysis of spectral power across a broader frequency range to differentiate the periodic qualities of ADHD time series RT data from (a) 1/frequency noise, and (b) control performance. We also assess the familiality of these frequencies by using a proband-sibling design. Method: Seventy-one children with ADHD, one of their siblings, and 50 control participants completed a simple RT task. Power across the RI frequency spectrum was calculated. The frequencies significantly differentiating the two groups were identified. Familiality was assessed in two ways: first, by comparing probands with their unaffected siblings and controls, and, second, by investigating the siblings of neuropsychologically impaired and unimpaired children with ADHD. Results: Analyses converged to highlight the potential importance of the .20-.26 Hz band in differentiating the periodic structure of ADHD RT time series data from both 1/frequency noise and control performance. This frequency band also showed the strongest evidence of familiality. Conclusions: RT performance of children with ADHD had a distinctive periodic structure. The band identified as most differentiating and familial was at a higher frequency than in most previous reports. This highlights the importance of employing tasks with faster interstimulus intervals that will allow a larger portion of the frequency spectrum to be examined.}},
  author       = {{Helps, Suzannah K and Broyd, Samantha J and Bitsakou, Paraskevi and Barke, Edmund}},
  issn         = {{0894-4105}},
  journal      = {{NEUROPSYCHOLOGY}},
  keywords     = {{DEFICIT HYPERACTIVITY DISORDER,endophenotype,attentional lapses,CHILDREN,INHIBITION,reaction time variability,DEFAULT-MODE,DELAY AVERSION,BRAIN ACTIVITY,INTRAINDIVIDUAL VARIABILITY,RESPONSE VARIABILITY,INTRA-SUBJECT VARIABILITY,attention-deficit/hyperactivity disorder,low frequency,ATTENTION-DEFICIT/HYPERACTIVITY DISORDER}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{711--719}},
  title        = {{Identifying a distinctive familial frequency band in reaction time fluctuations in ADHD}},
  url          = {{http://dx.doi.org/10.1037/a0024479}},
  volume       = {{25}},
  year         = {{2011}},
}

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