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Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug

Deepti Sahebrao Gholap UGent, Johanna Verhulst UGent, Wim Ceelen UGent and Frank Vanhaecke UGent (2012) ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 402(6). p.2121-2129
abstract
Quadrupole-based inductively coupled-mass spectrometry (ICP-MS) with pneumatic nebulization as a means of sample introduction was employed for quantification of platinum in blood and tissue samples of rats with peritoneal carcinomatosis, receiving intraperitoneal treatment with the Pt-containing chemotherapeutic drug oxaliplatin, and in the perfusate solution used for this purpose. The Pt levels were measured for various treatment conditions, i.e., with and without supporting treatment with the drug bevacizumab and at two different temperatures. Limits of detection obtained for platinum in blood and tissue samples were 0.3 and 2.0 pg g (,) (-1) respectively. Evaluation of drug penetration into the tumor, under different conditions of treatment, was carried out via laser ablation-ICP-MS. Quantitative mapping of the Pt distribution in tissue sections of rat was attempted relying on gelatin standards. The results show an influence of the temperature at which the treatment is carried out, while supporting administration of the drug bevacizumab did not seem to affect the results.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Platinum, Laser ablation-ICP-mass spectrometry, Biological samples, Quantitative mapping, Chemotherapeutic drugs, LA-ICP-MS, PERITONEAL CARCINOMATOSIS, CYTOREDUCTIVE SURGERY, TRACE-ELEMENTS, OVARIAN-CANCER, PLATINUM, CISPLATIN, SECTIONS, TISSUES, KIDNEY
journal title
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Anal. Bioanal. Chem.
volume
402
issue
6
pages
2121 - 2129
Web of Science type
Article
Web of Science id
000300308400014
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.659 (2012)
JCR rank
9/74 (2012)
JCR quartile
1 (2012)
ISSN
1618-2642
DOI
10.1007/s00216-011-5654-3
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2070356
handle
http://hdl.handle.net/1854/LU-2070356
date created
2012-03-20 15:19:30
date last changed
2012-03-21 14:29:29
@article{2070356,
  abstract     = {Quadrupole-based inductively coupled-mass spectrometry (ICP-MS) with pneumatic nebulization as a means of sample introduction was employed for quantification of platinum in blood and tissue samples of rats with peritoneal carcinomatosis, receiving intraperitoneal treatment with the Pt-containing chemotherapeutic drug oxaliplatin, and in the perfusate solution used for this purpose. The Pt levels were measured for various treatment conditions, i.e., with and without supporting treatment with the drug bevacizumab and at two different temperatures. Limits of detection obtained for platinum in blood and tissue samples were 0.3 and 2.0 pg g (,) (-1) respectively. Evaluation of drug penetration into the tumor, under different conditions of treatment, was carried out via laser ablation-ICP-MS. Quantitative mapping of the Pt distribution in tissue sections of rat was attempted relying on gelatin standards. The results show an influence of the temperature at which the treatment is carried out, while supporting administration of the drug bevacizumab did not seem to affect the results.},
  author       = {Gholap, Deepti Sahebrao and Verhulst, Johanna and Ceelen, Wim and Vanhaecke, Frank},
  issn         = {1618-2642},
  journal      = {ANALYTICAL AND BIOANALYTICAL CHEMISTRY},
  keyword      = {Platinum,Laser ablation-ICP-mass spectrometry,Biological samples,Quantitative mapping,Chemotherapeutic drugs,LA-ICP-MS,PERITONEAL CARCINOMATOSIS,CYTOREDUCTIVE SURGERY,TRACE-ELEMENTS,OVARIAN-CANCER,PLATINUM,CISPLATIN,SECTIONS,TISSUES,KIDNEY},
  language     = {eng},
  number       = {6},
  pages        = {2121--2129},
  title        = {Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug},
  url          = {http://dx.doi.org/10.1007/s00216-011-5654-3},
  volume       = {402},
  year         = {2012},
}

Chicago
Gholap, Deepti Sahebrao, Johanna Verhulst, Wim Ceelen, and Frank Vanhaecke. 2012. “Use of Pneumatic Nebulization and Laser Ablation-inductively Coupled Plasma-mass Spectrometry to Study the Distribution and Bioavailability of an Intraperitoneally Administered Pt-containing Chemotherapeutic Drug.” Analytical and Bioanalytical Chemistry 402 (6): 2121–2129.
APA
Gholap, D. S., Verhulst, J., Ceelen, W., & Vanhaecke, F. (2012). Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 402(6), 2121–2129.
Vancouver
1.
Gholap DS, Verhulst J, Ceelen W, Vanhaecke F. Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2012;402(6):2121–9.
MLA
Gholap, Deepti Sahebrao, Johanna Verhulst, Wim Ceelen, et al. “Use of Pneumatic Nebulization and Laser Ablation-inductively Coupled Plasma-mass Spectrometry to Study the Distribution and Bioavailability of an Intraperitoneally Administered Pt-containing Chemotherapeutic Drug.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 402.6 (2012): 2121–2129. Print.