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Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug

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Abstract
Quadrupole-based inductively coupled-mass spectrometry (ICP-MS) with pneumatic nebulization as a means of sample introduction was employed for quantification of platinum in blood and tissue samples of rats with peritoneal carcinomatosis, receiving intraperitoneal treatment with the Pt-containing chemotherapeutic drug oxaliplatin, and in the perfusate solution used for this purpose. The Pt levels were measured for various treatment conditions, i.e., with and without supporting treatment with the drug bevacizumab and at two different temperatures. Limits of detection obtained for platinum in blood and tissue samples were 0.3 and 2.0 pg g (,) (-1) respectively. Evaluation of drug penetration into the tumor, under different conditions of treatment, was carried out via laser ablation-ICP-MS. Quantitative mapping of the Pt distribution in tissue sections of rat was attempted relying on gelatin standards. The results show an influence of the temperature at which the treatment is carried out, while supporting administration of the drug bevacizumab did not seem to affect the results.
Keywords
Laser ablation-ICP-mass spectrometry, Platinum, Biological samples, Quantitative mapping, Chemotherapeutic drugs, LA-ICP-MS, PERITONEAL CARCINOMATOSIS, CYTOREDUCTIVE SURGERY, TRACE-ELEMENTS, OVARIAN-CANCER, PLATINUM, CISPLATIN, SECTIONS, TISSUES, KIDNEY

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MLA
Gholap, Deepti Sahebrao, Johanna Verhulst, Wim Ceelen, et al. “Use of Pneumatic Nebulization and Laser Ablation-inductively Coupled Plasma-mass Spectrometry to Study the Distribution and Bioavailability of an Intraperitoneally Administered Pt-containing Chemotherapeutic Drug.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 402.6 (2012): 2121–2129. Print.
APA
Gholap, D. S., Verhulst, J., Ceelen, W., & Vanhaecke, F. (2012). Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 402(6), 2121–2129.
Chicago author-date
Gholap, Deepti Sahebrao, Johanna Verhulst, Wim Ceelen, and Frank Vanhaecke. 2012. “Use of Pneumatic Nebulization and Laser Ablation-inductively Coupled Plasma-mass Spectrometry to Study the Distribution and Bioavailability of an Intraperitoneally Administered Pt-containing Chemotherapeutic Drug.” Analytical and Bioanalytical Chemistry 402 (6): 2121–2129.
Chicago author-date (all authors)
Gholap, Deepti Sahebrao, Johanna Verhulst, Wim Ceelen, and Frank Vanhaecke. 2012. “Use of Pneumatic Nebulization and Laser Ablation-inductively Coupled Plasma-mass Spectrometry to Study the Distribution and Bioavailability of an Intraperitoneally Administered Pt-containing Chemotherapeutic Drug.” Analytical and Bioanalytical Chemistry 402 (6): 2121–2129.
Vancouver
1.
Gholap DS, Verhulst J, Ceelen W, Vanhaecke F. Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2012;402(6):2121–9.
IEEE
[1]
D. S. Gholap, J. Verhulst, W. Ceelen, and F. Vanhaecke, “Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug,” ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 402, no. 6, pp. 2121–2129, 2012.
@article{2070356,
  abstract     = {Quadrupole-based inductively coupled-mass spectrometry (ICP-MS) with pneumatic nebulization as a means of sample introduction was employed for quantification of platinum in blood and tissue samples of rats with peritoneal carcinomatosis, receiving intraperitoneal treatment with the Pt-containing chemotherapeutic drug oxaliplatin, and in the perfusate solution used for this purpose. The Pt levels were measured for various treatment conditions, i.e., with and without supporting treatment with the drug bevacizumab and at two different temperatures. Limits of detection obtained for platinum in blood and tissue samples were 0.3 and 2.0 pg g (,) (-1) respectively. Evaluation of drug penetration into the tumor, under different conditions of treatment, was carried out via laser ablation-ICP-MS. Quantitative mapping of the Pt distribution in tissue sections of rat was attempted relying on gelatin standards. The results show an influence of the temperature at which the treatment is carried out, while supporting administration of the drug bevacizumab did not seem to affect the results.},
  author       = {Gholap, Deepti Sahebrao and Verhulst, Johanna and Ceelen, Wim and Vanhaecke, Frank},
  issn         = {1618-2642},
  journal      = {ANALYTICAL AND BIOANALYTICAL CHEMISTRY},
  keywords     = {Laser ablation-ICP-mass spectrometry,Platinum,Biological samples,Quantitative mapping,Chemotherapeutic drugs,LA-ICP-MS,PERITONEAL CARCINOMATOSIS,CYTOREDUCTIVE SURGERY,TRACE-ELEMENTS,OVARIAN-CANCER,PLATINUM,CISPLATIN,SECTIONS,TISSUES,KIDNEY},
  language     = {eng},
  number       = {6},
  pages        = {2121--2129},
  title        = {Use of pneumatic nebulization and laser ablation-inductively coupled plasma-mass spectrometry to study the distribution and bioavailability of an intraperitoneally administered Pt-containing chemotherapeutic drug},
  url          = {http://dx.doi.org/10.1007/s00216-011-5654-3},
  volume       = {402},
  year         = {2012},
}

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