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Al determination in whole blood samples as AlF via high-resolution continuum source graphite furnace molecular absorption spectrometry: potential application to forensic diagnosis of drowning

Maria Aramendia UGent, Maria Del Rosario Florez Garcia UGent, Michel Piette UGent, Frank Vanhaecke UGent and Martín Resano (2011) JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 26(10). p.1964-1973
abstract
In this work, a new methodology for direct determination of Al in whole blood samples by means of high-resolution continuum source graphite furnace molecular absorption spectrometry has been developed, based on the formation of the AlF diatomic molecule in the graphite furnace and the subsequent monitoring of its molecular absorption. The proposed methodology provides an alternative method to conventional atomic absorption, solving most of the problems related to the latter technique, particularly matrix effects, providing a straightforward alternative for blood analysis. The addition of NH(4)F center dot HF, which is required for promotion of the AlF molecule, was found to improve sample matrix removal for whole blood samples, whether they contain EDTA or heparin as anticoagulant agents. Besides minimizing residues in the graphite platform, this circumstance enabled the use of aqueous standards to build a calibration curve, avoiding the need for the cumbersome method of standard additions, while not affecting significantly detection capabilities (1.8 mu g L(-1) LOD). The method developed was also used for exploring the possibilities of Al as a chemical marker assisting forensic diagnosis of death-by-drowning. For this purpose, a set of samples (water and blood) obtained from 8 drowning suspects and two controls were analysed for their Al levels. Although additional studies with a large number of samples would be needed in order to draw definitive conclusions from a forensic point of view, a positive correlation between Al concentration in the drowning water and Al concentration in the blood of drowning suspects was found, supporting the validity of Al as a marker for drowning diagnosis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PLASMA-MASS SPECTROMETRY, ELECTROTHERMAL VAPORIZATION, HALOGENS, FLUORINE, DEATH, URINE, STRONTIUM, ALUMINUM, SOURCE AAS, ATOMIC-ABSORPTION
journal title
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
J. Anal. At. Spectrom.
volume
26
issue
10
pages
1964 - 1973
Web of Science type
Article
Web of Science id
000295080100002
JCR category
SPECTROSCOPY
JCR impact factor
3.22 (2011)
JCR rank
8/41 (2011)
JCR quartile
1 (2011)
ISSN
0267-9477
DOI
10.1039/c1ja10183h
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2070200
handle
http://hdl.handle.net/1854/LU-2070200
date created
2012-03-20 14:32:48
date last changed
2012-06-15 13:17:35
@article{2070200,
  abstract     = {In this work, a new methodology for direct determination of Al in whole blood samples by means of high-resolution continuum source graphite furnace molecular absorption spectrometry has been developed, based on the formation of the AlF diatomic molecule in the graphite furnace and the subsequent monitoring of its molecular absorption. The proposed methodology provides an alternative method to conventional atomic absorption, solving most of the problems related to the latter technique, particularly matrix effects, providing a straightforward alternative for blood analysis. The addition of NH(4)F center dot HF, which is required for promotion of the AlF molecule, was found to improve sample matrix removal for whole blood samples, whether they contain EDTA or heparin as anticoagulant agents. Besides minimizing residues in the graphite platform, this circumstance enabled the use of aqueous standards to build a calibration curve, avoiding the need for the cumbersome method of standard additions, while not affecting significantly detection capabilities (1.8 mu g L(-1) LOD). The method developed was also used for exploring the possibilities of Al as a chemical marker assisting forensic diagnosis of death-by-drowning. For this purpose, a set of samples (water and blood) obtained from 8 drowning suspects and two controls were analysed for their Al levels. Although additional studies with a large number of samples would be needed in order to draw definitive conclusions from a forensic point of view, a positive correlation between Al concentration in the drowning water and Al concentration in the blood of drowning suspects was found, supporting the validity of Al as a marker for drowning diagnosis.},
  author       = {Aramendia, Maria and Del Rosario Florez Garcia, Maria and Piette, Michel and Vanhaecke, Frank and Resano, Mart{\'i}n},
  issn         = {0267-9477},
  journal      = {JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY},
  keyword      = {PLASMA-MASS SPECTROMETRY,ELECTROTHERMAL VAPORIZATION,HALOGENS,FLUORINE,DEATH,URINE,STRONTIUM,ALUMINUM,SOURCE AAS,ATOMIC-ABSORPTION},
  language     = {eng},
  number       = {10},
  pages        = {1964--1973},
  title        = {Al determination in whole blood samples as AlF via high-resolution continuum source graphite furnace molecular absorption spectrometry: potential application to forensic diagnosis of drowning},
  url          = {http://dx.doi.org/10.1039/c1ja10183h},
  volume       = {26},
  year         = {2011},
}

Chicago
Aramendia, Maria, Maria Del Rosario Florez Garcia, Michel Piette, Frank Vanhaecke, and Martín Resano. 2011. “Al Determination in Whole Blood Samples as AlF via High-resolution Continuum Source Graphite Furnace Molecular Absorption Spectrometry: Potential Application to Forensic Diagnosis of Drowning.” Journal of Analytical Atomic Spectrometry 26 (10): 1964–1973.
APA
Aramendia, M., Del Rosario Florez Garcia, M., Piette, M., Vanhaecke, F., & Resano, M. (2011). Al determination in whole blood samples as AlF via high-resolution continuum source graphite furnace molecular absorption spectrometry: potential application to forensic diagnosis of drowning. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 26(10), 1964–1973.
Vancouver
1.
Aramendia M, Del Rosario Florez Garcia M, Piette M, Vanhaecke F, Resano M. Al determination in whole blood samples as AlF via high-resolution continuum source graphite furnace molecular absorption spectrometry: potential application to forensic diagnosis of drowning. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY. 2011;26(10):1964–73.
MLA
Aramendia, Maria, Maria Del Rosario Florez Garcia, Michel Piette, et al. “Al Determination in Whole Blood Samples as AlF via High-resolution Continuum Source Graphite Furnace Molecular Absorption Spectrometry: Potential Application to Forensic Diagnosis of Drowning.” JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 26.10 (2011): 1964–1973. Print.