Ghent University Academic Bibliography

Advanced

Estimation with Cox models: cause-specific survival analysis with misclassified cause of failure

Bart Van Rompaye UGent, Shabbar Jaffar and Els Goetghebeur UGent (2012) EPIDEMIOLOGY. 23(2). p.194-202
abstract
While epidemiologic and clinical research often aims to analyze predictors of specific endpoints, time-to-the-specific-event analysis can be hampered by problems with cause ascertainment. Under typical assumptions of competing risks analysis (and missing-data settings), we correct the cause-specific proportional hazards analysis when information on the reliability of diagnosis is available. Our method avoids bias in effect estimates at low cost in variance, thus offering a perspective for better-informed decision making. The ratio of different cause-specific hazards can be estimated flexibly for this purpose. It thus complements an all-cause analysis. In a sensitivity analysis, this approach can reveal the likely extent and direction of the bias of a standard cause-specific analysis when the diagnosis is suspect. These 2 uses are illustrated in a randomized vaccine trial and an epidemiologic cohort study, respectively.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SUBDISTRIBUTION, PNEUMOCOCCAL CONJUGATE VACCINE, TRIAL, GAMBIA, HAZARDS, ACCURACY, MORTALITY, DEATH CERTIFICATES, COMPETING RISKS, CORONARY-HEART-DISEASE
journal title
EPIDEMIOLOGY
Epidemiology
volume
23
issue
2
pages
194 - 202
Web of Science type
Article
Web of Science id
000300456500004
JCR category
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
JCR impact factor
5.738 (2012)
JCR rank
5/157 (2012)
JCR quartile
1 (2012)
ISSN
1044-3983
DOI
10.1097/EDE.0b013e3182454cad
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2069268
handle
http://hdl.handle.net/1854/LU-2069268
date created
2012-03-19 14:07:29
date last changed
2012-04-04 15:52:27
@article{2069268,
  abstract     = {While epidemiologic and clinical research often aims to analyze predictors of specific endpoints, time-to-the-specific-event analysis can be hampered by problems with cause ascertainment. Under typical assumptions of competing risks analysis (and missing-data settings), we correct the cause-specific proportional hazards analysis when information on the reliability of diagnosis is available. Our method avoids bias in effect estimates at low cost in variance, thus offering a perspective for better-informed decision making. The ratio of different cause-specific hazards can be estimated flexibly for this purpose. It thus complements an all-cause analysis. In a sensitivity analysis, this approach can reveal the likely extent and direction of the bias of a standard cause-specific analysis when the diagnosis is suspect. These 2 uses are illustrated in a randomized vaccine trial and an epidemiologic cohort study, respectively.},
  author       = {Van Rompaye, Bart and Jaffar, Shabbar and Goetghebeur, Els},
  issn         = {1044-3983},
  journal      = {EPIDEMIOLOGY},
  keyword      = {SUBDISTRIBUTION,PNEUMOCOCCAL CONJUGATE VACCINE,TRIAL,GAMBIA,HAZARDS,ACCURACY,MORTALITY,DEATH CERTIFICATES,COMPETING RISKS,CORONARY-HEART-DISEASE},
  language     = {eng},
  number       = {2},
  pages        = {194--202},
  title        = {Estimation with Cox models: cause-specific survival analysis with misclassified cause of failure},
  url          = {http://dx.doi.org/10.1097/EDE.0b013e3182454cad},
  volume       = {23},
  year         = {2012},
}

Chicago
Van Rompaye, Bart, Shabbar Jaffar, and Els Goetghebeur. 2012. “Estimation with Cox Models: Cause-specific Survival Analysis with Misclassified Cause of Failure.” Epidemiology 23 (2): 194–202.
APA
Van Rompaye, B., Jaffar, S., & Goetghebeur, E. (2012). Estimation with Cox models: cause-specific survival analysis with misclassified cause of failure. EPIDEMIOLOGY, 23(2), 194–202.
Vancouver
1.
Van Rompaye B, Jaffar S, Goetghebeur E. Estimation with Cox models: cause-specific survival analysis with misclassified cause of failure. EPIDEMIOLOGY. 2012;23(2):194–202.
MLA
Van Rompaye, Bart, Shabbar Jaffar, and Els Goetghebeur. “Estimation with Cox Models: Cause-specific Survival Analysis with Misclassified Cause of Failure.” EPIDEMIOLOGY 23.2 (2012): 194–202. Print.