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Uterine leiomyoma cytogenetics, III : interphase cytogenetic analysis of karyotypically normal uterine leiomyoma excludes possibility of undetected trisomy 12

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Abstract
Uterine leiomyoma, a benign tumor that histopathologically is rather homogeneous, was recently characterized cytogenetically. About 40% of the investigated tumors are associated with clonal chromosome abnormalities and five different subgroups have been identified, characterized by trisomy 12, t(12,14)(q14-15;q23-24), del(7q), t(1;2)(p36;p24), and 6p rearrangements. In our survey of 76 cases, trisomy 12 was observed in 10% of the abnormal cases. To exclude a possible underscoring of this abnormality, we reexamined 15 of the cases with normal karyotype by interphase cytogenetics using a chromosome 12 alphoid DNA probe.
Keywords
CHROMOSOME-ABERRATIONS, IN SITU HYBRIDIZATION, TUMOR-CELLS, DNA PROBES, REARRANGEMENTS, METAPHASE, NUCLEI

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Chicago
Vanni, R, Nadine Van Roy, U Lecca, and Franki Speleman. 1992. “Uterine Leiomyoma Cytogenetics, III : Interphase Cytogenetic Analysis of Karyotypically Normal Uterine Leiomyoma Excludes Possibility of Undetected Trisomy 12.” Cancer Genetics and Cytogenetics 62 (1): 40–42.
APA
Vanni, R., Van Roy, N., Lecca, U., & Speleman, F. (1992). Uterine leiomyoma cytogenetics, III : interphase cytogenetic analysis of karyotypically normal uterine leiomyoma excludes possibility of undetected trisomy 12. CANCER GENETICS AND CYTOGENETICS, 62(1), 40–42.
Vancouver
1.
Vanni R, Van Roy N, Lecca U, Speleman F. Uterine leiomyoma cytogenetics, III : interphase cytogenetic analysis of karyotypically normal uterine leiomyoma excludes possibility of undetected trisomy 12. CANCER GENETICS AND CYTOGENETICS. 1992;62(1):40–2.
MLA
Vanni, R, Nadine Van Roy, U Lecca, et al. “Uterine Leiomyoma Cytogenetics, III : Interphase Cytogenetic Analysis of Karyotypically Normal Uterine Leiomyoma Excludes Possibility of Undetected Trisomy 12.” CANCER GENETICS AND CYTOGENETICS 62.1 (1992): 40–42. Print.
@article{206854,
  abstract     = {Uterine leiomyoma, a benign tumor that histopathologically is rather homogeneous, was recently characterized cytogenetically. About 40\% of the investigated tumors are associated with clonal chromosome abnormalities and five different subgroups have been identified, characterized by trisomy 12, t(12,14)(q14-15;q23-24), del(7q), t(1;2)(p36;p24), and 6p rearrangements. In our survey of 76 cases, trisomy 12 was observed in 10\% of the abnormal cases. To exclude a possible underscoring of this abnormality, we reexamined 15 of the cases with normal karyotype by interphase cytogenetics using a chromosome 12 alphoid DNA probe.},
  author       = {Vanni, R and Van Roy, Nadine and Lecca, U and Speleman, Franki},
  issn         = {0165-4608},
  journal      = {CANCER GENETICS AND CYTOGENETICS},
  keyword      = {CHROMOSOME-ABERRATIONS,IN SITU HYBRIDIZATION,TUMOR-CELLS,DNA PROBES,REARRANGEMENTS,METAPHASE,NUCLEI},
  language     = {eng},
  number       = {1},
  pages        = {40--42},
  title        = {Uterine leiomyoma cytogenetics, III : interphase cytogenetic analysis of karyotypically normal uterine leiomyoma excludes possibility of undetected trisomy 12},
  url          = {http://dx.doi.org/10.1016/0165-4608(92)90035-7},
  volume       = {62},
  year         = {1992},
}

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