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On the trail of the glucocorticoid receptor: into the nucleus and back

Sofie Vandevyver UGent, Lien Dejager UGent and Claude Libert UGent (2012) TRAFFIC. 13(3). p.364-374
abstract
The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an important regulator of physiological and metabolic processes. In its inactive state, GR is unbound by ligand and resides in the cytoplasm in a chaperone complex. When it binds glucocorticoids, it is activated and translocates to the nucleus, where it functions as a transcription factor. However, the subcellular localization of GR is determined by the balance between its rates of nuclear import and export. The mechanism of GR nuclear transport has been extensively studied. Originally, it was believed that nuclear import of GR is initiated by dissociation of the chaperone complex in the cytoplasm. However, several studies show that the chaperone machinery is required for nuclear transport of GR. In this review, we summarize the contribution of various chaperone components involved in the nuclear transport of GR and propose an updated model of its nuclear import and export. Moreover, we review the importance of ligand-independent nuclear transport and compare the nuclear transport of GR with that of other steroid receptors.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
glucocorticoids, chaperone complex, nuclear receptor, nuclear transport, HEAT-SHOCK-PROTEIN, NF-KAPPA-B, DNA-BINDING DOMAIN, PROGESTERONE-RECEPTOR, STEROID-RECEPTORS, TRANSCRIPTIONAL ACTIVATION, MOLECULAR CHAPERONES, ANTIINFLAMMATORY PROPERTIES, MINERALOCORTICOID RECEPTOR, LOCALIZATION SIGNALS
journal title
TRAFFIC
Traffic
volume
13
issue
3
pages
364 - 374
Web of Science type
Review
Web of Science id
000300054100002
JCR category
CELL BIOLOGY
JCR impact factor
4.652 (2012)
JCR rank
53/181 (2012)
JCR quartile
2 (2012)
ISSN
1398-9219
DOI
10.1111/j.1600-0854.2011.01288.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2067249
handle
http://hdl.handle.net/1854/LU-2067249
date created
2012-03-15 13:19:17
date last changed
2012-06-26 14:32:37
@article{2067249,
  abstract     = {The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an important regulator of physiological and metabolic processes. In its inactive state, GR is unbound by ligand and resides in the cytoplasm in a chaperone complex. When it binds glucocorticoids, it is activated and translocates to the nucleus, where it functions as a transcription factor. However, the subcellular localization of GR is determined by the balance between its rates of nuclear import and export. The mechanism of GR nuclear transport has been extensively studied. Originally, it was believed that nuclear import of GR is initiated by dissociation of the chaperone complex in the cytoplasm. However, several studies show that the chaperone machinery is required for nuclear transport of GR. In this review, we summarize the contribution of various chaperone components involved in the nuclear transport of GR and propose an updated model of its nuclear import and export. Moreover, we review the importance of ligand-independent nuclear transport and compare the nuclear transport of GR with that of other steroid receptors.},
  author       = {Vandevyver, Sofie and Dejager, Lien and Libert, Claude},
  issn         = {1398-9219},
  journal      = {TRAFFIC},
  keyword      = {glucocorticoids,chaperone complex,nuclear receptor,nuclear transport,HEAT-SHOCK-PROTEIN,NF-KAPPA-B,DNA-BINDING DOMAIN,PROGESTERONE-RECEPTOR,STEROID-RECEPTORS,TRANSCRIPTIONAL ACTIVATION,MOLECULAR CHAPERONES,ANTIINFLAMMATORY PROPERTIES,MINERALOCORTICOID RECEPTOR,LOCALIZATION SIGNALS},
  language     = {eng},
  number       = {3},
  pages        = {364--374},
  title        = {On the trail of the glucocorticoid receptor: into the nucleus and back},
  url          = {http://dx.doi.org/10.1111/j.1600-0854.2011.01288.x},
  volume       = {13},
  year         = {2012},
}

Chicago
Vandevyver, Sofie, Lien Dejager, and Claude Libert. 2012. “On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back.” Traffic 13 (3): 364–374.
APA
Vandevyver, S., Dejager, L., & Libert, C. (2012). On the trail of the glucocorticoid receptor: into the nucleus and back. TRAFFIC, 13(3), 364–374.
Vancouver
1.
Vandevyver S, Dejager L, Libert C. On the trail of the glucocorticoid receptor: into the nucleus and back. TRAFFIC. 2012;13(3):364–74.
MLA
Vandevyver, Sofie, Lien Dejager, and Claude Libert. “On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back.” TRAFFIC 13.3 (2012): 364–374. Print.