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Virtual bench testing of new generation coronary stents

Peter Mortier UGent, Matthieu De Beule UGent, Patrick Segers UGent, Pascal Verdonck UGent and Benedict Verhegghe UGent (2011) EUROINTERVENTION. 7(3). p.369-376
abstract
Aims: The aim of this study was to compare the stent strut apposition and stent induced vessel wall stresses of currently used coronary stent designs. This may help to better understand their clinical performance and provide the insights necessary for further optimisation. Methods and results: We compared the stent strut apposition of six different stent designs when deployed (at 12 atm) in an idealised stenosed vessel using a novel approach based on finite element simulations. Additional insights into the mechanical behaviour of the investigated stents were obtained by virtually quantifying the stent induced vessel wall stresses. For the investigated stenosed vessel model, the percentage of malapposed struts (distance to wall > 10 mu m) ranged between 9% (Integrity stent) and 43% (Promus Element stent). The largest strut-artery distances were observed at the plaque shoulders. The 95 percentile of the axial stress within the intima ranges from 32 (Promus Element stent) to 83 kPa (Liberte stent). Stress peaks were mainly located at the inner curvatures of the vessel model and at the stent ends. Conclusions: For the investigated case, considerable differences were observed between the studied stent platforms in terms of stent strut apposition and stent induced vessel wall stresses. These differences in mechanical behaviour may help to explain clinical observations.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
IMPACT, THROMBOSIS, IMPLANTATION, MALAPPOSITION, APPOSITION, NATURAL-HISTORY, FOLLOW-UP, PACLITAXEL-ELUTING STENTS, INTRAVASCULAR ULTRASOUND ANALYSIS, stent induced wall stresses, ARTERY, stent strut apposition, finite element analysis
journal title
EUROINTERVENTION
Eurointervention
volume
7
issue
3
pages
369 - 376
Web of Science type
Article
Web of Science id
000294136600015
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
3.285 (2011)
JCR rank
36/117 (2011)
JCR quartile
2 (2011)
ISSN
1774-024X
DOI
10.4244/EIJV7I3A62
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2066720
handle
http://hdl.handle.net/1854/LU-2066720
date created
2012-03-14 21:39:15
date last changed
2012-03-21 09:31:09
@article{2066720,
  abstract     = {Aims: The aim of this study was to compare the stent strut apposition and stent induced vessel wall stresses of currently used coronary stent designs. This may help to better understand their clinical performance and provide the insights necessary for further optimisation. Methods and results: We compared the stent strut apposition of six different stent designs when deployed (at 12 atm) in an idealised stenosed vessel using a novel approach based on finite element simulations. Additional insights into the mechanical behaviour of the investigated stents were obtained by virtually quantifying the stent induced vessel wall stresses. For the investigated stenosed vessel model, the percentage of malapposed struts (distance to wall {\textrangle} 10 mu m) ranged between 9\% (Integrity stent) and 43\% (Promus Element stent). The largest strut-artery distances were observed at the plaque shoulders. The 95 percentile of the axial stress within the intima ranges from 32 (Promus Element stent) to 83 kPa (Liberte stent). Stress peaks were mainly located at the inner curvatures of the vessel model and at the stent ends. Conclusions: For the investigated case, considerable differences were observed between the studied stent platforms in terms of stent strut apposition and stent induced vessel wall stresses. These differences in mechanical behaviour may help to explain clinical observations.},
  author       = {Mortier, Peter and De Beule, Matthieu and Segers, Patrick and Verdonck, Pascal and Verhegghe, Benedict},
  issn         = {1774-024X},
  journal      = {EUROINTERVENTION},
  keyword      = {IMPACT,THROMBOSIS,IMPLANTATION,MALAPPOSITION,APPOSITION,NATURAL-HISTORY,FOLLOW-UP,PACLITAXEL-ELUTING STENTS,INTRAVASCULAR ULTRASOUND ANALYSIS,stent induced wall stresses,ARTERY,stent strut apposition,finite element analysis},
  language     = {eng},
  number       = {3},
  pages        = {369--376},
  title        = {Virtual bench testing of new generation coronary stents},
  url          = {http://dx.doi.org/10.4244/EIJV7I3A62},
  volume       = {7},
  year         = {2011},
}

Chicago
Mortier, Peter, Matthieu De Beule, Patrick Segers, Pascal Verdonck, and Benedict Verhegghe. 2011. “Virtual Bench Testing of New Generation Coronary Stents.” Eurointervention 7 (3): 369–376.
APA
Mortier, Peter, De Beule, M., Segers, P., Verdonck, P., & Verhegghe, B. (2011). Virtual bench testing of new generation coronary stents. EUROINTERVENTION, 7(3), 369–376.
Vancouver
1.
Mortier P, De Beule M, Segers P, Verdonck P, Verhegghe B. Virtual bench testing of new generation coronary stents. EUROINTERVENTION. 2011;7(3):369–76.
MLA
Mortier, Peter, Matthieu De Beule, Patrick Segers, et al. “Virtual Bench Testing of New Generation Coronary Stents.” EUROINTERVENTION 7.3 (2011): 369–376. Print.