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Vitamin C deficiency: more than just a nutritional disorder

Joris Delanghe (UGent) , Michel Langlois (UGent) , Marc De Buyzere (UGent) , Na Na, Jin Ouyang, Marijn Speeckaert (UGent) and Mathieu Torck (UGent)
(2011) GENES AND NUTRITION. 6(4). p.341-346
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Abstract
Although vitamin C deficiency and scurvy are generally considered as pure nutritional disorders, only a minority of the vitamin C concentration is determined by food intake. In the presence of transition metals (iron and copper), the antiscorbutic factor shifts from an antioxidant to a pro-oxidant function. Haptoglobin (Hp) is a plasma alpha-2 glycoprotein characterized by 3 common phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). Its free hemoglobin (Hb)-binding capacity prevents Hb-driven oxidative damage. When the antioxidant capacity of Hp is insufficient, its role is taken over by hemopexin (heme-binding protein) and by vitamin C (free radical scavenger). The Hp 2-2 phenotype has a lower capacity to inhibit oxidation and vitamin C depletion. In this article, two consequences of this major finding are tackled. The Hp polymorphism is an important non-nutritional modifying factor in the pathogenesis of vitamin C deficiency and scurvy, which may explain the success of long-range human migration by the natural selection of some populations characterized by high Hp 1 allele frequencies. Moreover, we propose tailoring the recommended dietary allowance (RDA) values of vitamin C, taking into consideration the Hp phenotype dependency.
Keywords
SERUM ASCORBIC-ACID, HAPTOGLOBIN POLYMORPHISM, SCURVY, POPULATION, INFECTION, HUMANS, Haptoglobin, Polymorphism, Scurvy, Vitamin C

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Chicago
Delanghe, Joris, Michel Langlois, Marc De Buyzere, Na Na, Jin Ouyang, Marijn Speeckaert, and Mathieu Torck. 2011. “Vitamin C Deficiency: More Than Just a Nutritional Disorder.” Genes and Nutrition.
APA
Delanghe, Joris, Langlois, M., De Buyzere, M., Na, N., Ouyang, J., Speeckaert, M., & Torck, M. (2011). Vitamin C deficiency: more than just a nutritional disorder. GENES AND NUTRITION.
Vancouver
1.
Delanghe J, Langlois M, De Buyzere M, Na N, Ouyang J, Speeckaert M, et al. Vitamin C deficiency: more than just a nutritional disorder. GENES AND NUTRITION. 2011. p. 341–6.
MLA
Delanghe, Joris, Michel Langlois, Marc De Buyzere, et al. “Vitamin C Deficiency: More Than Just a Nutritional Disorder.” GENES AND NUTRITION 2011 : 341–346. Print.
@misc{2064531,
  abstract     = {Although vitamin C deficiency and scurvy are generally considered as pure nutritional disorders, only a minority of the vitamin C concentration is determined by food intake. In the presence of transition metals (iron and copper), the antiscorbutic factor shifts from an antioxidant to a pro-oxidant function. Haptoglobin (Hp) is a plasma alpha-2 glycoprotein characterized by 3 common phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). Its free hemoglobin (Hb)-binding capacity prevents Hb-driven oxidative damage. When the antioxidant capacity of Hp is insufficient, its role is taken over by hemopexin (heme-binding protein) and by vitamin C (free radical scavenger). The Hp 2-2 phenotype has a lower capacity to inhibit oxidation and vitamin C depletion. In this article, two consequences of this major finding are tackled. The Hp polymorphism is an important non-nutritional modifying factor in the pathogenesis of vitamin C deficiency and scurvy, which may explain the success of long-range human migration by the natural selection of some populations characterized by high Hp 1 allele frequencies. Moreover, we propose tailoring the recommended dietary allowance (RDA) values of vitamin C, taking into consideration the Hp phenotype dependency.},
  author       = {Delanghe, Joris and Langlois, Michel and De Buyzere, Marc and Na, Na and Ouyang, Jin and Speeckaert, Marijn and Torck, Mathieu},
  issn         = {1555-8932},
  language     = {eng},
  number       = {4},
  pages        = {341--346},
  series       = {GENES AND NUTRITION},
  title        = {Vitamin C deficiency: more than just a nutritional disorder},
  url          = {http://dx.doi.org/10.1007/s12263-011-0237-7},
  volume       = {6},
  year         = {2011},
}

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