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Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling

Tim Pieters UGent, Frans Van Roy UGent and Jolanda van Hengel UGent (2012) FRONTIERS IN BIOSCIENCE-LANDMARK. 17. p.1669-1694
abstract
The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell junctions. In vertebrates, three major types of junctions are responsible for epithelial integrity: adherens junctions, tight junctions, and desmosomes. p120 catenin (p120ctn) is an Armadillo family member and a component of the cadherin-catenin complex in the adherens junction. It fulfils pleiotropic functions according to its subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small RhoGTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn obtained from in vitro experiments has been confirmed and extended by using different animal models. It has become clear that p120ctn is essential for normal development and homeostasis, at least in frog and mammals. p120ctn is a Src substrate that can be phosphorylated at different tyrosine, serine and threonine residues and can dock various kinases and phosphatases. Thereby, p120ctn regulates the phosphorylation status and the junctional stability of the cadherin-catenin complex. Multiple p120ctn isoforms are generated by alternative splicing, which allows the translation to be initiated from four start codons and enables the inclusion of four alternatively used exons. We will discuss the effects of different p120ctn isoforms on cadherin turnover and intracellular signaling, in particular RhoGTPase activity and phosphorylation events.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GROWTH-FACTOR RECEPTOR, HUMAN P120(CTN) CATENIN, MEDIATED TRANSCRIPTIONAL REPRESSION, LUNG-CANCER CELLS, CADHERIN-CATENIN COMPLEX, Rac1, RhoGTPases, Cancer, EMT, Phosphorylation, Isoforms, Alternative splicing, Trafficking, Development, Knockdown, Cdc42, Kaiso, Review, Inflammation, Migration, Invasion, PROTEIN-TYROSINE-PHOSPHATASE, RHO-FAMILY GTPASES, EPITHELIAL-MESENCHYMAL TRANSITION, Proliferation, RhoA, Cancer, Tumor, p120ctn, Catenin, Armadillo, Cadherin, Knock-out, BETA-CATENIN, N-CADHERIN
journal title
FRONTIERS IN BIOSCIENCE-LANDMARK
Front. Biosci.
volume
17
pages
1669 - 1694
Web of Science type
Article
Web of Science id
000300054400007
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
3.286 (2012)
JCR rank
110/288 (2012)
JCR quartile
2 (2012)
ISSN
1093-9946
DOI
10.2741/4012
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2063247
handle
http://hdl.handle.net/1854/LU-2063247
date created
2012-03-08 17:41:08
date last changed
2012-06-26 14:32:36
@article{2063247,
  abstract     = {The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell junctions. In vertebrates, three major types of junctions are responsible for epithelial integrity: adherens junctions, tight junctions, and desmosomes. p120 catenin (p120ctn) is an Armadillo family member and a component of the cadherin-catenin complex in the adherens junction. It fulfils pleiotropic functions according to its subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small RhoGTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn obtained from in vitro experiments has been confirmed and extended by using different animal models. It has become clear that p120ctn is essential for normal development and homeostasis, at least in frog and mammals. p120ctn is a Src substrate that can be phosphorylated at different tyrosine, serine and threonine residues and can dock various kinases and phosphatases. Thereby, p120ctn regulates the phosphorylation status and the junctional stability of the cadherin-catenin complex. Multiple p120ctn isoforms are generated by alternative splicing, which allows the translation to be initiated from four start codons and enables the inclusion of four alternatively used exons. We will discuss the effects of different p120ctn isoforms on cadherin turnover and intracellular signaling, in particular RhoGTPase activity and phosphorylation events.},
  author       = {Pieters, Tim and Van Roy, Frans and van Hengel, Jolanda},
  issn         = {1093-9946},
  journal      = {FRONTIERS IN BIOSCIENCE-LANDMARK},
  keyword      = {GROWTH-FACTOR RECEPTOR,HUMAN P120(CTN) CATENIN,MEDIATED TRANSCRIPTIONAL REPRESSION,LUNG-CANCER CELLS,CADHERIN-CATENIN COMPLEX,Rac1,RhoGTPases,Cancer,EMT,Phosphorylation,Isoforms,Alternative splicing,Trafficking,Development,Knockdown,Cdc42,Kaiso,Review,Inflammation,Migration,Invasion,PROTEIN-TYROSINE-PHOSPHATASE,RHO-FAMILY GTPASES,EPITHELIAL-MESENCHYMAL TRANSITION,Proliferation,RhoA,Cancer,Tumor,p120ctn,Catenin,Armadillo,Cadherin,Knock-out,BETA-CATENIN,N-CADHERIN},
  language     = {eng},
  pages        = {1669--1694},
  title        = {Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling},
  url          = {http://dx.doi.org/10.2741/4012},
  volume       = {17},
  year         = {2012},
}

Chicago
Pieters, Tim, Frans Van Roy, and Jolanda van Hengel. 2012. “Functions of P120ctn Isoforms in Cell-cell Adhesion and Intracellular Signaling.” Frontiers in Bioscience-landmark 17: 1669–1694.
APA
Pieters, T., Van Roy, F., & van Hengel, J. (2012). Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling. FRONTIERS IN BIOSCIENCE-LANDMARK, 17, 1669–1694.
Vancouver
1.
Pieters T, Van Roy F, van Hengel J. Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling. FRONTIERS IN BIOSCIENCE-LANDMARK. 2012;17:1669–94.
MLA
Pieters, Tim, Frans Van Roy, and Jolanda van Hengel. “Functions of P120ctn Isoforms in Cell-cell Adhesion and Intracellular Signaling.” FRONTIERS IN BIOSCIENCE-LANDMARK 17 (2012): 1669–1694. Print.