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Functions of p120ctn in development and disease

Tim Pieters UGent, Jolanda van Hengel UGent and Frans Van Roy UGent (2012) FRONTIERS IN BIOSCIENCE-LANDMARK. 17. p.760-783
abstract
p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing. These isoforms fulfill pleiotropic functions according to their subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small Rho GTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn has grown remarkably, and this has been achieved in part by using different animal models. At least in frog and mammals, p120ctn is essential for normal development and homeostasis. Here we will discuss the effects of different p120ctn isoforms on cadherin turnover and on signaling in the cytoplasm and the nucleus. We will also elaborate on the structure and function of other members of the p120ctn subfamily: ARVCF, p0071 and delta-catenin. Finally, we will overview the respective roles of p120ctn family members in pathological processes, and particularly in cancer as p120ctn is frequently downregulated or mislocalized in various human tumors.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Knock-Out, Cadherin, Catenin, Armadillo, p120ctn, Knockdown, Development, Trafficking, Alternative Splicing, Isoforms, EMT, phosphorylation, Cancer, ARVCF, p0071, delta-catenin, RhoGTPases, RhoA, Rac1, Cdc42, Kaiso, Proliferation, Cancer, Tumor, Migration, Invasion, Anchorage Independent Growth, Inflammation, Review, CELL-CELL ADHESION, TYROSINE KINASE SUBSTRATE, RHO-FAMILY GTPASES, LUNG-CANCER CELLS, MEDIATED TRANSCRIPTIONAL REPRESSION, EPITHELIAL-MESENCHYMAL TRANSITION, ADENOMATOUS POLYPOSIS-COLI, CADHERIN-CATENIN COMPLEXES, HUMAN P120(CTN) CATENIN, DELTA-CATENIN
journal title
FRONTIERS IN BIOSCIENCE-LANDMARK
Front. Biosci.
volume
17
pages
760 - 783
Web of Science type
Article
Web of Science id
000300049600023
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
3.286 (2012)
JCR rank
110/288 (2012)
JCR quartile
2 (2012)
ISSN
1093-9946
DOI
10.2741/3956
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2063240
handle
http://hdl.handle.net/1854/LU-2063240
date created
2012-03-08 17:36:19
date last changed
2012-06-26 14:32:36
@article{2063240,
  abstract     = {p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing. These isoforms fulfill pleiotropic functions according to their subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small Rho GTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn has grown remarkably, and this has been achieved in part by using different animal models. At least in frog and mammals, p120ctn is essential for normal development and homeostasis. Here we will discuss the effects of different p120ctn isoforms on cadherin turnover and on signaling in the cytoplasm and the nucleus. We will also elaborate on the structure and function of other members of the p120ctn subfamily: ARVCF, p0071 and delta-catenin. Finally, we will overview the respective roles of p120ctn family members in pathological processes, and particularly in cancer as p120ctn is frequently downregulated or mislocalized in various human tumors.},
  author       = {Pieters, Tim and van Hengel, Jolanda and Van Roy, Frans},
  issn         = {1093-9946},
  journal      = {FRONTIERS IN BIOSCIENCE-LANDMARK},
  keyword      = {Knock-Out,Cadherin,Catenin,Armadillo,p120ctn,Knockdown,Development,Trafficking,Alternative Splicing,Isoforms,EMT,phosphorylation,Cancer,ARVCF,p0071,delta-catenin,RhoGTPases,RhoA,Rac1,Cdc42,Kaiso,Proliferation,Cancer,Tumor,Migration,Invasion,Anchorage Independent Growth,Inflammation,Review,CELL-CELL ADHESION,TYROSINE KINASE SUBSTRATE,RHO-FAMILY GTPASES,LUNG-CANCER CELLS,MEDIATED TRANSCRIPTIONAL REPRESSION,EPITHELIAL-MESENCHYMAL TRANSITION,ADENOMATOUS POLYPOSIS-COLI,CADHERIN-CATENIN COMPLEXES,HUMAN P120(CTN) CATENIN,DELTA-CATENIN},
  language     = {eng},
  pages        = {760--783},
  title        = {Functions of p120ctn in development and disease},
  url          = {http://dx.doi.org/10.2741/3956},
  volume       = {17},
  year         = {2012},
}

Chicago
Pieters, Tim, Jolanda van Hengel, and Frans Van Roy. 2012. “Functions of P120ctn in Development and Disease.” Frontiers in Bioscience-landmark 17: 760–783.
APA
Pieters, T., van Hengel, J., & Van Roy, F. (2012). Functions of p120ctn in development and disease. FRONTIERS IN BIOSCIENCE-LANDMARK, 17, 760–783.
Vancouver
1.
Pieters T, van Hengel J, Van Roy F. Functions of p120ctn in development and disease. FRONTIERS IN BIOSCIENCE-LANDMARK. 2012;17:760–83.
MLA
Pieters, Tim, Jolanda van Hengel, and Frans Van Roy. “Functions of P120ctn in Development and Disease.” FRONTIERS IN BIOSCIENCE-LANDMARK 17 (2012): 760–783. Print.