Advanced search
1 file | 196.91 KB

New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens

Author
Organization
Abstract
In this study, three new models were developed for efficacy testing of mycotoxin detoxifying agents in relation to recent European guidelines. In the first model, deoxynivalenol was given to broiler chickens as an intra-crop bolus together with a mycotoxin detoxifying agent in order to study the plasma concentration-time profile of deoxynivalenol. In the second model the same oral bolus was given, preceded by an oral bolus of mycotoxin detoxifying agent, to make sure the detoxifying agent was present in the whole intestinal tract when the mycotoxin was administered. In the third model, the mycotoxin detoxifying agent was mixed in the feed of broiler chickens, and after one week feeding, deoxynivalenol was given as an oral bolus. In order to evaluate the efficacy of these agents, plasma concentration-time profiles were set up and the main toxicokinetic parameters were compared. Two commercially available mycotoxin detoxifying agents were tested, but they were not able to lower the oral availability of deoxynivalenol. As a positive control, activated carbon was used. We showed that activated carbon significantly reduces the absorption and oral availability of deoxynivalenol in all three models. Therefore, it can be concluded that these models are able to demonstrate the efficacy of mycotoxin detoxifying agents in relation to EFSA guidelines.
Keywords
CONTAMINATED WHEAT, FEED ADDITIVES, ADSORBENT MATERIALS, modeling, deoxynivalenol, legal assessment, mycotoxin detoxifying agent, mycotoxins, FUSARIUM MYCOTOXINS, efficacy testing, GLUCOMANNAN, PERFORMANCE, ZEARALENONE, PARAMETERS, VITRO, DETOXIFICATION

Downloads

    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 196.91 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Devreese, Mathias, Ann Osselaere, Joline Goossens, Virginie Vandenbroucke, Siegrid De Baere, Mia Eeckhout, Patrick De Backer, and Siska Croubels. 2012. “New Bolus Models for in Vivo Efficacy Testing of Mycotoxin Detoxifying Agents in Relation to EFSA Guidelines, Assessed Using Deoxynivalenol in Broiler Chickens.” Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment 29 (7): 1101–1107.
APA
Devreese, M., Osselaere, A., Goossens, J., Vandenbroucke, V., De Baere, S., Eeckhout, M., De Backer, P., et al. (2012). New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 29(7), 1101–1107.
Vancouver
1.
Devreese M, Osselaere A, Goossens J, Vandenbroucke V, De Baere S, Eeckhout M, et al. New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT. 2012;29(7):1101–7.
MLA
Devreese, Mathias, Ann Osselaere, Joline Goossens, et al. “New Bolus Models for in Vivo Efficacy Testing of Mycotoxin Detoxifying Agents in Relation to EFSA Guidelines, Assessed Using Deoxynivalenol in Broiler Chickens.” FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT 29.7 (2012): 1101–1107. Print.
@article{2056292,
  abstract     = {In this study, three new models were developed for efficacy testing of mycotoxin detoxifying agents in relation to recent European guidelines. In the first model, deoxynivalenol was given to broiler chickens as an intra-crop bolus together with a mycotoxin detoxifying agent in order to study the plasma concentration-time profile of deoxynivalenol. In the second model the same oral bolus was given, preceded by an oral bolus of mycotoxin detoxifying agent, to make sure the detoxifying agent was present in the whole intestinal tract when the mycotoxin was administered. In the third model, the mycotoxin detoxifying agent was mixed in the feed of broiler chickens, and after one week feeding, deoxynivalenol was given as an oral bolus. In order to evaluate the efficacy of these agents, plasma concentration-time profiles were set up and the main toxicokinetic parameters were compared. Two commercially available mycotoxin detoxifying agents were tested, but they were not able to lower the oral availability of deoxynivalenol. As a positive control, activated carbon was used. We showed that activated carbon significantly reduces the absorption and oral availability of deoxynivalenol in all three models. Therefore, it can be concluded that these models are able to demonstrate the efficacy of mycotoxin detoxifying agents in relation to EFSA guidelines.},
  author       = {Devreese, Mathias and Osselaere, Ann and Goossens, Joline and Vandenbroucke, Virginie and De Baere, Siegrid and Eeckhout, Mia and De Backer, Patrick and Croubels, Siska},
  issn         = {1944-0049},
  journal      = {FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE \& RISK ASSESSMENT},
  keyword      = {CONTAMINATED WHEAT,FEED ADDITIVES,ADSORBENT MATERIALS,modeling,deoxynivalenol,legal assessment,mycotoxin detoxifying agent,mycotoxins,FUSARIUM MYCOTOXINS,efficacy testing,GLUCOMANNAN,PERFORMANCE,ZEARALENONE,PARAMETERS,VITRO,DETOXIFICATION},
  language     = {eng},
  number       = {7},
  pages        = {1101--1107},
  title        = {New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens},
  url          = {http://dx.doi.org/10.1080/19440049.2012.671788},
  volume       = {29},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: