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New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens

Mathias Devreese UGent, Ann Osselaere UGent, Joline Goossens UGent, Virginie Vandenbroucke UGent, Siegrid De Baere UGent, Mia Eeckhout UGent, Patrick De Backer UGent and Siska Croubels UGent (2012) FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT. 29(7). p.1101-1107
abstract
In this study, three new models were developed for efficacy testing of mycotoxin detoxifying agents in relation to recent European guidelines. In the first model, deoxynivalenol was given to broiler chickens as an intra-crop bolus together with a mycotoxin detoxifying agent in order to study the plasma concentration-time profile of deoxynivalenol. In the second model the same oral bolus was given, preceded by an oral bolus of mycotoxin detoxifying agent, to make sure the detoxifying agent was present in the whole intestinal tract when the mycotoxin was administered. In the third model, the mycotoxin detoxifying agent was mixed in the feed of broiler chickens, and after one week feeding, deoxynivalenol was given as an oral bolus. In order to evaluate the efficacy of these agents, plasma concentration-time profiles were set up and the main toxicokinetic parameters were compared. Two commercially available mycotoxin detoxifying agents were tested, but they were not able to lower the oral availability of deoxynivalenol. As a positive control, activated carbon was used. We showed that activated carbon significantly reduces the absorption and oral availability of deoxynivalenol in all three models. Therefore, it can be concluded that these models are able to demonstrate the efficacy of mycotoxin detoxifying agents in relation to EFSA guidelines.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CONTAMINATED WHEAT, FEED ADDITIVES, ADSORBENT MATERIALS, modeling, deoxynivalenol, legal assessment, mycotoxin detoxifying agent, mycotoxins, FUSARIUM MYCOTOXINS, efficacy testing, GLUCOMANNAN, PERFORMANCE, ZEARALENONE, PARAMETERS, VITRO, DETOXIFICATION
journal title
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
Food Addit. Contam. Part A-Chem.
volume
29
issue
7
pages
1101 - 1107
Web of Science type
Article
Web of Science id
000304821400010
JCR category
FOOD SCIENCE & TECHNOLOGY
JCR impact factor
2.22 (2012)
JCR rank
32/123 (2012)
JCR quartile
2 (2012)
ISSN
1944-0049
DOI
10.1080/19440049.2012.671788
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2056292
handle
http://hdl.handle.net/1854/LU-2056292
date created
2012-03-02 09:01:39
date last changed
2014-03-11 09:37:24
@article{2056292,
  abstract     = {In this study, three new models were developed for efficacy testing of mycotoxin detoxifying agents in relation to recent European guidelines. In the first model, deoxynivalenol was given to broiler chickens as an intra-crop bolus together with a mycotoxin detoxifying agent in order to study the plasma concentration-time profile of deoxynivalenol. In the second model the same oral bolus was given, preceded by an oral bolus of mycotoxin detoxifying agent, to make sure the detoxifying agent was present in the whole intestinal tract when the mycotoxin was administered. In the third model, the mycotoxin detoxifying agent was mixed in the feed of broiler chickens, and after one week feeding, deoxynivalenol was given as an oral bolus. In order to evaluate the efficacy of these agents, plasma concentration-time profiles were set up and the main toxicokinetic parameters were compared. Two commercially available mycotoxin detoxifying agents were tested, but they were not able to lower the oral availability of deoxynivalenol. As a positive control, activated carbon was used. We showed that activated carbon significantly reduces the absorption and oral availability of deoxynivalenol in all three models. Therefore, it can be concluded that these models are able to demonstrate the efficacy of mycotoxin detoxifying agents in relation to EFSA guidelines.},
  author       = {Devreese, Mathias and Osselaere, Ann and Goossens, Joline and Vandenbroucke, Virginie and De Baere, Siegrid and Eeckhout, Mia and De Backer, Patrick and Croubels, Siska},
  issn         = {1944-0049},
  journal      = {FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE \& RISK ASSESSMENT},
  keyword      = {CONTAMINATED WHEAT,FEED ADDITIVES,ADSORBENT MATERIALS,modeling,deoxynivalenol,legal assessment,mycotoxin detoxifying agent,mycotoxins,FUSARIUM MYCOTOXINS,efficacy testing,GLUCOMANNAN,PERFORMANCE,ZEARALENONE,PARAMETERS,VITRO,DETOXIFICATION},
  language     = {eng},
  number       = {7},
  pages        = {1101--1107},
  title        = {New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens},
  url          = {http://dx.doi.org/10.1080/19440049.2012.671788},
  volume       = {29},
  year         = {2012},
}

Chicago
Devreese, Mathias, Ann Osselaere, Joline Goossens, Virginie Vandenbroucke, Siegrid De Baere, Mia Eeckhout, Patrick De Backer, and Siska Croubels. 2012. “New Bolus Models for in Vivo Efficacy Testing of Mycotoxin Detoxifying Agents in Relation to EFSA Guidelines, Assessed Using Deoxynivalenol in Broiler Chickens.” Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment 29 (7): 1101–1107.
APA
Devreese, M., Osselaere, A., Goossens, J., Vandenbroucke, V., De Baere, S., Eeckhout, M., De Backer, P., et al. (2012). New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 29(7), 1101–1107.
Vancouver
1.
Devreese M, Osselaere A, Goossens J, Vandenbroucke V, De Baere S, Eeckhout M, et al. New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens. FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT. 2012;29(7):1101–7.
MLA
Devreese, Mathias, Ann Osselaere, Joline Goossens, et al. “New Bolus Models for in Vivo Efficacy Testing of Mycotoxin Detoxifying Agents in Relation to EFSA Guidelines, Assessed Using Deoxynivalenol in Broiler Chickens.” FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT 29.7 (2012): 1101–1107. Print.