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Simulation of the mass response of the evaporative light-scattering detector

(1992) ANALYTICAL CHEMISTRY. 64(9). p.1056-1062
Author
Organization
Abstract
A computer simulation model was developed to predict the response of the evaporative light scattering detector. Hereby, not only the nebulization, the evaporation, and the light scattering phenomenon were modeled, but moreover, the decreased efficiency of the detection process due to photomultiplier saturation was quantified and included in the model. The program allows one to calculate calibration curves corresponding to a given set of experimental conditions. Hereby, a single-point calibration is sufficient to obtain absolute peak areas. Besides the detector settings and the mobile-phase flow rate, the peak width was most decisive. The usefulness of the model was shown by comparing both experimental and simulated calibration curves obtained at various values of the gas pressure, mobile-phase flow rate, and peak width: very good fits were obtained under all experimental conditions. The simulation program elaborated enables one to investigate quantitatively the influence of all detector variables so that they can be optimized easily. Moreover, calibration curves corresponding to each peak within a chromatogram may be calculated, even for unknown compounds, thus allowing a reproducible and accurate quantitative estimation of all the compounds separated.
Keywords
PERFORMANCE LIQUID-CHROMATOGRAPHY, SEPARATION

Citation

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Chicago
Van Der Meeren, Paul, Jean Vanderdeelen, and Leon Baert. 1992. “Simulation of the Mass Response of the Evaporative Light-scattering Detector.” Analytical Chemistry 64 (9): 1056–1062.
APA
Van Der Meeren, P., Vanderdeelen, J., & Baert, L. (1992). Simulation of the mass response of the evaporative light-scattering detector. ANALYTICAL CHEMISTRY, 64(9), 1056–1062.
Vancouver
1.
Van Der Meeren P, Vanderdeelen J, Baert L. Simulation of the mass response of the evaporative light-scattering detector. ANALYTICAL CHEMISTRY. 1992;64(9):1056–62.
MLA
Van Der Meeren, Paul, Jean Vanderdeelen, and Leon Baert. “Simulation of the Mass Response of the Evaporative Light-scattering Detector.” ANALYTICAL CHEMISTRY 64.9 (1992): 1056–1062. Print.
@article{205490,
  abstract     = {A computer simulation model was developed to predict the response of the evaporative light scattering detector. Hereby, not only the nebulization, the evaporation, and the light scattering phenomenon were modeled, but moreover, the decreased efficiency of the detection process due to photomultiplier saturation was quantified and included in the model. The program allows one to calculate calibration curves corresponding to a given set of experimental conditions. Hereby, a single-point calibration is sufficient to obtain absolute peak areas. Besides the detector settings and the mobile-phase flow rate, the peak width was most decisive. The usefulness of the model was shown by comparing both experimental and simulated calibration curves obtained at various values of the gas pressure, mobile-phase flow rate, and peak width: very good fits were obtained under all experimental conditions. The simulation program elaborated enables one to investigate quantitatively the influence of all detector variables so that they can be optimized easily. Moreover, calibration curves corresponding to each peak within a chromatogram may be calculated, even for unknown compounds, thus allowing a reproducible and accurate quantitative estimation of all the compounds separated.},
  author       = {Van Der Meeren, Paul and Vanderdeelen, Jean and Baert, Leon},
  issn         = {0003-2700},
  journal      = {ANALYTICAL CHEMISTRY},
  keyword      = {PERFORMANCE LIQUID-CHROMATOGRAPHY,SEPARATION},
  language     = {eng},
  number       = {9},
  pages        = {1056--1062},
  title        = {Simulation of the mass response of the evaporative light-scattering detector},
  url          = {http://dx.doi.org/10.1021/ac00033a017},
  volume       = {64},
  year         = {1992},
}

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