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The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours

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Abstract
The duration of the protective effect of 50 and 100-mu-g of inhaled salmeterol against methacholine-induced bronchoconstriction was compared with that of 200-mu-g of inhaled salbutamol in 12 patients with asthma with a baseline FEV1 of at least 70% and a provocative concentration of inhaled methacholine causing a 20% fall in FEV1 (PC20) greater-than-or-equal-to 8 mg/ml. The study was placebo controlled, double blind, randomized, and crossover. The bronchodilating effect was no longer significant 4 hours after inhalation of salbutamol, whereas the effect was still present 12 hours after administration of 50 and 100-mu-g of salmeterol. All active treatments caused PC20 to increase at 1 hour (p < 0.05). PC20 (milligrams per milliliter) thus reached 3.7 +/- 0.8 after placebo, 13.8 +/- 3.0 after 50-mu-g of salmeterol, 23.2 +/- 4.7 after 100-mu-g of salmeterol, and 13.9 +/- 3.4 after 200-mu-g of salbutamol. The protective effect of 200-mu-g of salbutamol was no longer significant at 4 hours, whereas both doses of salmeterol protected against methacholine challenge up to 12 hours after inhalation (p < 0.01). An increased incidence of tremor (2/12) and palpitations (2/12) was recorded after inhalation of 100-mu-g of salmeterol. We conclude that inhalation of 50 or 100-mu-g of salmeterol causes a long-lasting bronchodilatation and protects against methacholine-induced bronchoconstriction for at least 12 hours.
Keywords
BRONCHODILATION, SALMETEROL, SYMPATHOMIMETICS, AEROSOL, SALBUTAMOL, ASTHMA, METHACHOLINE CHALLENGE, PROTECTIVE EFFECT

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MLA
Derom, Eric, Romain Pauwels, and Marcel E Van Der Straeten. “The Effect of Inhaled Salmeterol on Methacholine Responsiveness in Subjects with Asthma up to 12 Hours.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 89.4 (1992): 811–815. Print.
APA
Derom, E., Pauwels, R., & Van Der Straeten, M. E. (1992). The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89(4), 811–815.
Chicago author-date
Derom, Eric, Romain Pauwels, and Marcel E Van Der Straeten. 1992. “The Effect of Inhaled Salmeterol on Methacholine Responsiveness in Subjects with Asthma up to 12 Hours.” Journal of Allergy and Clinical Immunology 89 (4): 811–815.
Chicago author-date (all authors)
Derom, Eric, Romain Pauwels, and Marcel E Van Der Straeten. 1992. “The Effect of Inhaled Salmeterol on Methacholine Responsiveness in Subjects with Asthma up to 12 Hours.” Journal of Allergy and Clinical Immunology 89 (4): 811–815.
Vancouver
1.
Derom E, Pauwels R, Van Der Straeten ME. The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1992;89(4):811–5.
IEEE
[1]
E. Derom, R. Pauwels, and M. E. Van Der Straeten, “The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours,” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 89, no. 4, pp. 811–815, 1992.
@article{205235,
  abstract     = {The duration of the protective effect of 50 and 100-mu-g of inhaled salmeterol against methacholine-induced bronchoconstriction was compared with that of 200-mu-g of inhaled salbutamol in 12 patients with asthma with a baseline FEV1 of at least 70% and a provocative concentration of inhaled methacholine causing a 20% fall in FEV1 (PC20) greater-than-or-equal-to 8 mg/ml. The study was placebo controlled, double blind, randomized, and crossover. The bronchodilating effect was no longer significant 4 hours after inhalation of salbutamol, whereas the effect was still present 12 hours after administration of 50 and 100-mu-g of salmeterol. All active treatments caused PC20 to increase at 1 hour (p < 0.05). PC20 (milligrams per milliliter) thus reached 3.7 +/- 0.8 after placebo, 13.8 +/- 3.0 after 50-mu-g of salmeterol, 23.2 +/- 4.7 after 100-mu-g of salmeterol, and 13.9 +/- 3.4 after 200-mu-g of salbutamol. The protective effect of 200-mu-g of salbutamol was no longer significant at 4 hours, whereas both doses of salmeterol protected against methacholine challenge up to 12 hours after inhalation (p < 0.01). An increased incidence of tremor (2/12) and palpitations (2/12) was recorded after inhalation of 100-mu-g of salmeterol. We conclude that inhalation of 50 or 100-mu-g of salmeterol causes a long-lasting bronchodilatation and protects against methacholine-induced bronchoconstriction for at least 12 hours.},
  author       = {Derom, Eric and Pauwels, Romain and Van Der Straeten, Marcel E},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keywords     = {BRONCHODILATION,SALMETEROL,SYMPATHOMIMETICS,AEROSOL,SALBUTAMOL,ASTHMA,METHACHOLINE CHALLENGE,PROTECTIVE EFFECT},
  language     = {eng},
  number       = {4},
  pages        = {811--815},
  title        = {The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours},
  volume       = {89},
  year         = {1992},
}