Advanced search
1 file | 1.66 MB Add to list

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

(2011) NATURE GENETICS. 43(7). p.673-678
Author
Organization
Abstract
The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene.
Keywords
LEUKEMOGENESIS, RNA, IKAROS, TARGETS, MICE, MUTATIONS, EXPRESSION, NOTCH1, HUMAN CANCERS, C-MYC, T-ALL, leukemia, miRNA, microRNA, cancer

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.66 MB

Citation

Please use this url to cite or link to this publication:

MLA
Mavrakis, Konstantinos J, Joni Van der Meulen, Andrew L Wolfe, et al. “A Cooperative microRNA-tumor Suppressor Gene Network in Acute T-cell Lymphoblastic Leukemia (T-ALL).” NATURE GENETICS 43.7 (2011): 673–678. Print.
APA
Mavrakis, K. J., Van der Meulen, J., Wolfe, A. L., Liu, X., Mets, E., Taghon, T., Khan, A. A., et al. (2011). A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). NATURE GENETICS, 43(7), 673–678.
Chicago author-date
Mavrakis, Konstantinos J, Joni Van der Meulen, Andrew L Wolfe, Xiaoping Liu, Evelien Mets, Tom Taghon, Aly A Khan, et al. 2011. “A Cooperative microRNA-tumor Suppressor Gene Network in Acute T-cell Lymphoblastic Leukemia (T-ALL).” Nature Genetics 43 (7): 673–678.
Chicago author-date (all authors)
Mavrakis, Konstantinos J, Joni Van der Meulen, Andrew L Wolfe, Xiaoping Liu, Evelien Mets, Tom Taghon, Aly A Khan, Manu Setty, Pieter Rondou, Peter Vandenberghe, Eric Delabesse, Yves Benoit, Nicholas B Socci, Christina S Leslie, Pieter Van Vlierberghe, Franki Speleman, and Hans-Guido Wendel. 2011. “A Cooperative microRNA-tumor Suppressor Gene Network in Acute T-cell Lymphoblastic Leukemia (T-ALL).” Nature Genetics 43 (7): 673–678.
Vancouver
1.
Mavrakis KJ, Van der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, et al. A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). NATURE GENETICS. 2011;43(7):673–8.
IEEE
[1]
K. J. Mavrakis et al., “A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL),” NATURE GENETICS, vol. 43, no. 7, pp. 673–678, 2011.
@article{2051743,
  abstract     = {The importance of individual microRNAs (miRNAs) has been established in specific cancers. However, a comprehensive analysis of the contribution of miRNAs to the pathogenesis of any specific cancer is lacking. Here we show that in T-cell acute lymphoblastic leukemia (T-ALL), a small set of miRNAs is responsible for the cooperative suppression of several tumor suppressor genes. Cross-comparison of miRNA expression profiles in human T-ALL with the results of an unbiased miRNA library screen allowed us to identify five miRNAs (miR-19b, miR-20a, miR-26a, miR-92 and miR-223) that are capable of promoting T-ALL development in a mouse model and which account for the majority of miRNA expression in human T-ALL. Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action in T-ALL reveals a striking pattern of miRNA-tumor suppressor gene.},
  author       = {Mavrakis, Konstantinos J and Van der Meulen, Joni and Wolfe, Andrew L and Liu, Xiaoping and Mets, Evelien and Taghon, Tom and Khan, Aly A and Setty, Manu and Rondou, Pieter and Vandenberghe, Peter and Delabesse, Eric and Benoit, Yves and Socci, Nicholas B and Leslie, Christina S and Van Vlierberghe, Pieter and Speleman, Franki and Wendel, Hans-Guido},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keywords     = {LEUKEMOGENESIS,RNA,IKAROS,TARGETS,MICE,MUTATIONS,EXPRESSION,NOTCH1,HUMAN CANCERS,C-MYC,T-ALL,leukemia,miRNA,microRNA,cancer},
  language     = {eng},
  number       = {7},
  pages        = {673--678},
  title        = {A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)},
  url          = {http://dx.doi.org/10.1038/ng.858},
  volume       = {43},
  year         = {2011},
}

Altmetric
View in Altmetric
Web of Science
Times cited: