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Sentinel node procedures in gynecologic cancers: an overview

NOORTJE VAN OOSTRUM UGent, Amin Makar UGent and Rudy Van den Broecke UGent (2012) ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 91(2). p.174-181
abstract
The aim of this study was to assess the value of sentinel lymph node procedures in gynecologic cancers. A systematic literature overview, using the PubMed database, was performed. In early stage vulvar, endometrial and cervical cancer, lymph node status is the most important prognostic factor. Lymphadenectomy, performed for adequate staging, is associated with high morbidity rates. Sentinel node procedures hold the promise of adequate staging with less treatment-related morbidity. Sentinel lymph node procedures in patients with early-stage vulvar cancer are associated with low recurrence rates, excellent survival, lower morbidity and shorter hospital stay compared to classical inguinal dissection. Therefore, these procedures should be the standard of care in early-stage unilateral vulvar cancer. Reports on sentinel lymph node procedures in endometrial and cervical cancer are ambiguous. The procedures in these cancers are reported in small studies only. Detection rates vary depending on the used injection sites and the used tracers. Bilateral detection rates are low and are not mentioned by default. Large controlled multi-institutional studies are necessary to evaluate the validity and the prognostic significance of the sentinel lymph node procedures in endometrial and cervical cancer.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
IDENTIFICATION, STAGE VULVAR CANCER, INJECTION, ENDOMETRIAL CANCER, CERVICAL-CANCER, RADICAL HYSTERECTOMY, SURGICAL-MANAGEMENT, BIOPSY, CARCINOMA, LYMPHADENECTOMY, vulvar cancer, survival, sentinel lymph node procedure, lymph node state, endometrial cancer, Cervical cancer
journal title
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Acta Obstet. Gynecol. Scand.
volume
91
issue
2
pages
174 - 181
Web of Science type
Review
Web of Science id
000299205200004
JCR category
OBSTETRICS & GYNECOLOGY
JCR impact factor
1.85 (2012)
JCR rank
32/77 (2012)
JCR quartile
2 (2012)
ISSN
0001-6349
DOI
10.1111/j.1600-0412.2011.01302.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2048981
handle
http://hdl.handle.net/1854/LU-2048981
date created
2012-02-28 13:27:03
date last changed
2012-03-19 15:59:49
@article{2048981,
  abstract     = {The aim of this study was to assess the value of sentinel lymph node procedures in gynecologic cancers. A systematic literature overview, using the PubMed database, was performed. In early stage vulvar, endometrial and cervical cancer, lymph node status is the most important prognostic factor. Lymphadenectomy, performed for adequate staging, is associated with high morbidity rates. Sentinel node procedures hold the promise of adequate staging with less treatment-related morbidity. Sentinel lymph node procedures in patients with early-stage vulvar cancer are associated with low recurrence rates, excellent survival, lower morbidity and shorter hospital stay compared to classical inguinal dissection. Therefore, these procedures should be the standard of care in early-stage unilateral vulvar cancer. Reports on sentinel lymph node procedures in endometrial and cervical cancer are ambiguous. The procedures in these cancers are reported in small studies only. Detection rates vary depending on the used injection sites and the used tracers. Bilateral detection rates are low and are not mentioned by default. Large controlled multi-institutional studies are necessary to evaluate the validity and the prognostic significance of the sentinel lymph node procedures in endometrial and cervical cancer.},
  author       = {VAN OOSTRUM, NOORTJE and Makar, Amin and Van den Broecke, Rudy},
  issn         = {0001-6349},
  journal      = {ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA},
  keyword      = {IDENTIFICATION,STAGE VULVAR CANCER,INJECTION,ENDOMETRIAL CANCER,CERVICAL-CANCER,RADICAL HYSTERECTOMY,SURGICAL-MANAGEMENT,BIOPSY,CARCINOMA,LYMPHADENECTOMY,vulvar cancer,survival,sentinel lymph node procedure,lymph node state,endometrial cancer,Cervical cancer},
  language     = {eng},
  number       = {2},
  pages        = {174--181},
  title        = {Sentinel node procedures in gynecologic cancers: an overview},
  url          = {http://dx.doi.org/10.1111/j.1600-0412.2011.01302.x},
  volume       = {91},
  year         = {2012},
}

Chicago
VAN OOSTRUM, NOORTJE, Amin Makar, and Rudy Van den Broecke. 2012. “Sentinel Node Procedures in Gynecologic Cancers: An Overview.” Acta Obstetricia Et Gynecologica Scandinavica 91 (2): 174–181.
APA
VAN OOSTRUM, N., Makar, A., & Van den Broecke, R. (2012). Sentinel node procedures in gynecologic cancers: an overview. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 91(2), 174–181.
Vancouver
1.
VAN OOSTRUM N, Makar A, Van den Broecke R. Sentinel node procedures in gynecologic cancers: an overview. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2012;91(2):174–81.
MLA
VAN OOSTRUM, NOORTJE, Amin Makar, and Rudy Van den Broecke. “Sentinel Node Procedures in Gynecologic Cancers: An Overview.” ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 91.2 (2012): 174–181. Print.