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Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities

(2010) MOLECULAR DIVERSITY. 14(4). p.767-776
Author
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Abstract
The synthesis and biological activity of a hitherto unknown class of compounds, the imidazolylthiazolidin-4-ones, are described. A two-step procedure has been elaborated starting from our previously described 2-aminoimidazoles. The application of microwave irradiation has been proven to be beneficial for the condensation of the imine with mercaptoacetic acid leading to the formation of imidazolylthiazolidin-4-ones. None of the compounds showed antiviral activity at subtoxic concentrations. Several compounds displayed a moderate cytostatic activity. These data form the basis for further improvement of the potential antiproliferative activity of this class of compounds.
Keywords
2-aminoimidazoles, Thiazolidin-4-ones, Imidazolylthiazolidins, Antiviral activity, Cytostatic activity, MCR, 3CCR, Microwave-assisted organic synthesis, PSEUDOMONAS-AERUGINOSA BIOFILMS, MODERN ORGANIC-SYNTHESIS, ANTI-HIV, ANTICONVULSANT ACTIVITY, ANTI-HIV-1 AGENTS, DERIVATIVES, INHIBITORS, 2, 3-DIARYL-1, 3-THIAZOLIDIN-4-ONES, 4-THIAZOLIDINONES, 2-AMINOIMIDAZOLES

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Citation

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MLA
Modha, Sachin G., et al. “Microwave-Assisted Synthesis of a Novel Class of Imidazolylthiazolidin-4-Ones and Evaluation of Its Biological Activities.” MOLECULAR DIVERSITY, vol. 14, no. 4, 2010, pp. 767–76.
APA
Modha, S. G., Mehta, V. P., Ermolat’ev, D., Balzarini, J., Van Hecke, K., Van Meervelt, L., & Van der Eycken, E. V. (2010). Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities. MOLECULAR DIVERSITY, 14(4), 767–776.
Chicago author-date
Modha, Sachin G, Vaibhav Pravinchandra Mehta, Denis Ermolat’ev, Jan Balzarini, Kristof Van Hecke, Luc Van Meervelt, and Erik V Van der Eycken. 2010. “Microwave-Assisted Synthesis of a Novel Class of Imidazolylthiazolidin-4-Ones and Evaluation of Its Biological Activities.” MOLECULAR DIVERSITY 14 (4): 767–76.
Chicago author-date (all authors)
Modha, Sachin G, Vaibhav Pravinchandra Mehta, Denis Ermolat’ev, Jan Balzarini, Kristof Van Hecke, Luc Van Meervelt, and Erik V Van der Eycken. 2010. “Microwave-Assisted Synthesis of a Novel Class of Imidazolylthiazolidin-4-Ones and Evaluation of Its Biological Activities.” MOLECULAR DIVERSITY 14 (4): 767–776.
Vancouver
1.
Modha SG, Mehta VP, Ermolat’ev D, Balzarini J, Van Hecke K, Van Meervelt L, et al. Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities. MOLECULAR DIVERSITY. 2010;14(4):767–76.
IEEE
[1]
S. G. Modha et al., “Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities,” MOLECULAR DIVERSITY, vol. 14, no. 4, pp. 767–776, 2010.
@article{2045602,
  abstract     = {The synthesis and biological activity of a hitherto unknown class of compounds, the imidazolylthiazolidin-4-ones, are described. A two-step procedure has been elaborated starting from our previously described 2-aminoimidazoles. The application of microwave irradiation has been proven to be beneficial for the condensation of the imine with mercaptoacetic acid leading to the formation of imidazolylthiazolidin-4-ones. None of the compounds showed antiviral activity at subtoxic concentrations. Several compounds displayed a moderate cytostatic activity. These data form the basis for further improvement of the potential antiproliferative activity of this class of compounds.},
  author       = {Modha, Sachin G and Mehta, Vaibhav Pravinchandra and Ermolat'ev, Denis and Balzarini, Jan and Van Hecke, Kristof and Van Meervelt, Luc and Van der Eycken, Erik V},
  issn         = {1381-1991},
  journal      = {MOLECULAR DIVERSITY},
  keywords     = {2-aminoimidazoles,Thiazolidin-4-ones,Imidazolylthiazolidins,Antiviral activity,Cytostatic activity,MCR,3CCR,Microwave-assisted organic synthesis,PSEUDOMONAS-AERUGINOSA BIOFILMS,MODERN ORGANIC-SYNTHESIS,ANTI-HIV,ANTICONVULSANT ACTIVITY,ANTI-HIV-1 AGENTS,DERIVATIVES,INHIBITORS,2,3-DIARYL-1,3-THIAZOLIDIN-4-ONES,4-THIAZOLIDINONES,2-AMINOIMIDAZOLES},
  language     = {eng},
  number       = {4},
  pages        = {767--776},
  title        = {Microwave-assisted synthesis of a novel class of imidazolylthiazolidin-4-ones and evaluation of its biological activities},
  url          = {http://dx.doi.org/10.1007/s11030-009-9221-1},
  volume       = {14},
  year         = {2010},
}

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