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COPD is associated with reduced pulmonary interstitial expression of pentraxin-3

Geert Van Pottelberge, Ken Bracke (UGent) , Nele Pauwels (UGent) , Frank Vermassen (UGent) , Guy Joos (UGent) and Guy Brusselle (UGent)
(2012) EUROPEAN RESPIRATORY JOURNAL. 39(4). p.830-838
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Organization
Abstract
Pentraxin-3 (PTX3) is involved in antimicrobial defense, apoptotic cell clearance and extracellular matrix stability. As these processes are altered in Chronic Obstructive Pulmonary Disease (COPD), we aimed to investigate PTX3 expression in patients with this disease.PTX3 expression was quantified by immunohistochemical staining in lungs of never smokers, smokers without COPD and in patients with COPD GOLD stage I, II and III&IV. Messenger RNA (mRNA) expression was examined in total lung tissue by qRT-PCR. PTX3 concentration was measured in induced sputum and in plasma by ELISA.PTX3 is mainly localized in the interstitium of small airways and alveolar walls. There were no significant differences in pulmonary, sputum and plasma PTX3 expression between study groups. However, PTX3 expression in small airways correlated significantly with the forced expiratory volume in one second (r=0.35 ; p=0.004). In the alveolar walls, PTX3 expression correlated significantly with carbon monoxide transfer coefficient (r=0.28; p=0.04). In sputum, PTX3 levels were highly correlated with the number of neutrophils. Finally, systemic levels of PTX3 tended to be lower in severe COPD compared to mild COPD.In COPD, airflow limitation and reduced transfer coefficient for carbon monoxide are associated with lower pulmonary interstitial expression of PTX3.
Keywords
PTX3 EXPRESSION, EPITHELIAL-CELLS, DENDRITIC CELLS, INNATE IMMUNITY, INFLAMMATION, EMPHYSEMA, CARDIOVASCULAR-DISEASES, ACUTE LUNG INJURY, extracellular matrix, induced sputum, Airway inflammation, chronic obstructive pulmonary disease, innate immunity, COMMUNITY-ACQUIRED PNEUMONIA, PATTERN-RECOGNITION RECEPTOR

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Citation

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MLA
Van Pottelberge, Geert, Ken Bracke, Nele Pauwels, et al. “COPD Is Associated with Reduced Pulmonary Interstitial Expression of Pentraxin-3.” EUROPEAN RESPIRATORY JOURNAL 39.4 (2012): 830–838. Print.
APA
Van Pottelberge, G., Bracke, K., Pauwels, N., Vermassen, F., Joos, G., & Brusselle, G. (2012). COPD is associated with reduced pulmonary interstitial expression of pentraxin-3. EUROPEAN RESPIRATORY JOURNAL, 39(4), 830–838.
Chicago author-date
Van Pottelberge, Geert, Ken Bracke, Nele Pauwels, Frank Vermassen, Guy Joos, and Guy Brusselle. 2012. “COPD Is Associated with Reduced Pulmonary Interstitial Expression of Pentraxin-3.” European Respiratory Journal 39 (4): 830–838.
Chicago author-date (all authors)
Van Pottelberge, Geert, Ken Bracke, Nele Pauwels, Frank Vermassen, Guy Joos, and Guy Brusselle. 2012. “COPD Is Associated with Reduced Pulmonary Interstitial Expression of Pentraxin-3.” European Respiratory Journal 39 (4): 830–838.
Vancouver
1.
Van Pottelberge G, Bracke K, Pauwels N, Vermassen F, Joos G, Brusselle G. COPD is associated with reduced pulmonary interstitial expression of pentraxin-3. EUROPEAN RESPIRATORY JOURNAL. 2012;39(4):830–8.
IEEE
[1]
G. Van Pottelberge, K. Bracke, N. Pauwels, F. Vermassen, G. Joos, and G. Brusselle, “COPD is associated with reduced pulmonary interstitial expression of pentraxin-3,” EUROPEAN RESPIRATORY JOURNAL, vol. 39, no. 4, pp. 830–838, 2012.
@article{2045297,
  abstract     = {Pentraxin-3 (PTX3) is involved in antimicrobial defense, apoptotic cell clearance and extracellular matrix stability. As these processes are altered in Chronic Obstructive Pulmonary Disease (COPD), we aimed to investigate PTX3 expression in patients with this disease.PTX3 expression was quantified by immunohistochemical staining in lungs of never smokers, smokers without COPD and in patients with COPD GOLD stage I, II and III&IV. Messenger RNA (mRNA) expression was examined in total lung tissue by qRT-PCR. PTX3 concentration was measured in induced sputum and in plasma by ELISA.PTX3 is mainly localized in the interstitium of small airways and alveolar walls. There were no significant differences in pulmonary, sputum and plasma PTX3 expression between study groups. However, PTX3 expression in small airways correlated significantly with the forced expiratory volume in one second (r=0.35 ; p=0.004). In the alveolar walls, PTX3 expression correlated significantly with carbon monoxide transfer coefficient (r=0.28; p=0.04). In sputum, PTX3 levels were highly correlated with the number of neutrophils. Finally, systemic levels of PTX3 tended to be lower in severe COPD compared to mild COPD.In COPD, airflow limitation and reduced transfer coefficient for carbon monoxide are associated with lower pulmonary interstitial expression of PTX3.},
  author       = {Van Pottelberge, Geert and Bracke, Ken and Pauwels, Nele and Vermassen, Frank and Joos, Guy and Brusselle, Guy},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keywords     = {PTX3 EXPRESSION,EPITHELIAL-CELLS,DENDRITIC CELLS,INNATE IMMUNITY,INFLAMMATION,EMPHYSEMA,CARDIOVASCULAR-DISEASES,ACUTE LUNG INJURY,extracellular matrix,induced sputum,Airway inflammation,chronic obstructive pulmonary disease,innate immunity,COMMUNITY-ACQUIRED PNEUMONIA,PATTERN-RECOGNITION RECEPTOR},
  language     = {eng},
  number       = {4},
  pages        = {830--838},
  title        = {COPD is associated with reduced pulmonary interstitial expression of pentraxin-3},
  url          = {http://dx.doi.org/10.1183/09031936.00138110},
  volume       = {39},
  year         = {2012},
}

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