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COPD is associated with reduced pulmonary interstitial expression of pentraxin-3

Geert Van Pottelberge UGent, Ken Bracke UGent, Nele Pauwels UGent, Frank Vermassen UGent, Guy Joos UGent and Guy Brusselle UGent (2012) EUROPEAN RESPIRATORY JOURNAL. 39(4). p.830-838
abstract
Pentraxin-3 (PTX3) is involved in antimicrobial defense, apoptotic cell clearance and extracellular matrix stability. As these processes are altered in Chronic Obstructive Pulmonary Disease (COPD), we aimed to investigate PTX3 expression in patients with this disease.PTX3 expression was quantified by immunohistochemical staining in lungs of never smokers, smokers without COPD and in patients with COPD GOLD stage I, II and III&IV. Messenger RNA (mRNA) expression was examined in total lung tissue by qRT-PCR. PTX3 concentration was measured in induced sputum and in plasma by ELISA.PTX3 is mainly localized in the interstitium of small airways and alveolar walls. There were no significant differences in pulmonary, sputum and plasma PTX3 expression between study groups. However, PTX3 expression in small airways correlated significantly with the forced expiratory volume in one second (r=0.35 ; p=0.004). In the alveolar walls, PTX3 expression correlated significantly with carbon monoxide transfer coefficient (r=0.28; p=0.04). In sputum, PTX3 levels were highly correlated with the number of neutrophils. Finally, systemic levels of PTX3 tended to be lower in severe COPD compared to mild COPD.In COPD, airflow limitation and reduced transfer coefficient for carbon monoxide are associated with lower pulmonary interstitial expression of PTX3.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PATTERN-RECOGNITION RECEPTOR, COMMUNITY-ACQUIRED PNEUMONIA, innate immunity, chronic obstructive pulmonary disease, Airway inflammation, induced sputum, extracellular matrix, ACUTE LUNG INJURY, CARDIOVASCULAR-DISEASES, EPITHELIAL-CELLS, PTX3 EXPRESSION, DENDRITIC CELLS, INNATE IMMUNITY, INFLAMMATION, EMPHYSEMA
journal title
EUROPEAN RESPIRATORY JOURNAL
Eur. Resp. J.
volume
39
issue
4
pages
830 - 838
Web of Science type
Article
Web of Science id
000302354900008
JCR category
RESPIRATORY SYSTEM
JCR impact factor
6.355 (2012)
JCR rank
3/50 (2012)
JCR quartile
1 (2012)
ISSN
0903-1936
DOI
10.1183/09031936.00138110
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2045297
handle
http://hdl.handle.net/1854/LU-2045297
date created
2012-02-27 09:55:04
date last changed
2012-09-12 15:40:51
@article{2045297,
  abstract     = {Pentraxin-3 (PTX3) is involved in antimicrobial defense, apoptotic cell clearance and extracellular matrix stability. As these processes are altered in Chronic Obstructive Pulmonary Disease (COPD), we aimed to investigate PTX3 expression in patients with this disease.PTX3 expression was quantified by immunohistochemical staining in lungs of never smokers, smokers without COPD and in patients with COPD GOLD stage I, II and III\&IV. Messenger RNA (mRNA) expression was examined in total lung tissue by qRT-PCR. PTX3 concentration was measured in induced sputum and in plasma by ELISA.PTX3 is mainly localized in the interstitium of small airways and alveolar walls. There were no significant differences in pulmonary, sputum and plasma PTX3 expression between study groups. However, PTX3 expression in small airways correlated significantly with the forced expiratory volume in one second (r=0.35 ; p=0.004). In the alveolar walls, PTX3 expression correlated significantly with carbon monoxide transfer coefficient (r=0.28; p=0.04). In sputum, PTX3 levels were highly correlated with the number of neutrophils. Finally, systemic levels of PTX3 tended to be lower in severe COPD compared to mild COPD.In COPD, airflow limitation and reduced transfer coefficient for carbon monoxide are associated with lower pulmonary interstitial expression of PTX3.},
  author       = {Van Pottelberge, Geert and Bracke, Ken and Pauwels, Nele and Vermassen, Frank and Joos, Guy and Brusselle, Guy},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keyword      = {PATTERN-RECOGNITION RECEPTOR,COMMUNITY-ACQUIRED PNEUMONIA,innate immunity,chronic obstructive pulmonary disease,Airway inflammation,induced sputum,extracellular matrix,ACUTE LUNG INJURY,CARDIOVASCULAR-DISEASES,EPITHELIAL-CELLS,PTX3 EXPRESSION,DENDRITIC CELLS,INNATE IMMUNITY,INFLAMMATION,EMPHYSEMA},
  language     = {eng},
  number       = {4},
  pages        = {830--838},
  title        = {COPD is associated with reduced pulmonary interstitial expression of pentraxin-3},
  url          = {http://dx.doi.org/10.1183/09031936.00138110},
  volume       = {39},
  year         = {2012},
}

Chicago
Van Pottelberge, Geert, Ken Bracke, Nele Pauwels, Frank Vermassen, Guy Joos, and Guy Brusselle. 2012. “COPD Is Associated with Reduced Pulmonary Interstitial Expression of Pentraxin-3.” European Respiratory Journal 39 (4): 830–838.
APA
Van Pottelberge, G., Bracke, K., Pauwels, N., Vermassen, F., Joos, G., & Brusselle, G. (2012). COPD is associated with reduced pulmonary interstitial expression of pentraxin-3. EUROPEAN RESPIRATORY JOURNAL, 39(4), 830–838.
Vancouver
1.
Van Pottelberge G, Bracke K, Pauwels N, Vermassen F, Joos G, Brusselle G. COPD is associated with reduced pulmonary interstitial expression of pentraxin-3. EUROPEAN RESPIRATORY JOURNAL. 2012;39(4):830–8.
MLA
Van Pottelberge, Geert, Ken Bracke, Nele Pauwels, et al. “COPD Is Associated with Reduced Pulmonary Interstitial Expression of Pentraxin-3.” EUROPEAN RESPIRATORY JOURNAL 39.4 (2012): 830–838. Print.