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An omnibus consistent adaptive percentile modified Wilcoxon rank sum test with applications in gene expression studies

Olivier Thas UGent, Lieven Clement UGent, John Rayner, Beatriz Carvalho and Wim Van Criekinge UGent (2012) BIOMETRICS. 68(2). p.446-454
abstract
We present an adaptive percentile modified Wilcoxon rank sum test for the two-sample problem. The test is basically a Wilcoxon rank sum test applied on a fraction of the sample observations, and the fraction is adaptively determined by the sample observations. Most of the theory is developed under a location-shift model, but we demonstrate that the test is also meaningful for testing against more general alternatives. The test may be particularly useful for the analysis of massive datasets in which quasi-automatic hypothesis testing is required. We investigate the power characteristics of the new test in a simulation study, and we apply the test to a microarray experiment on colorectal cancer. These empirical studies demonstrate that the new test has good overall power and that it succeeds better in finding differentially expressed genes as compared to other popular tests. We conclude that the new nonparametric test is widely applicable and that its power is comparable to the power of the Baumgartner-Weiß-Schindler test.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CARCINOMA PROGRESSION, Adaptive test, PUTATIVE ONCOGENES, COLORECTAL ADENOMA, ONE-SAMPLE, Wilcoxon rank sum test, Location-shift, Baumgartner-Weiß-Schindler test, Differential gene expression, STATISTICS, CANCER
journal title
BIOMETRICS
Biometrics
volume
68
issue
2
pages
446 - 454
Web of Science type
Article
Web of Science id
000305691900013
JCR category
STATISTICS & PROBABILITY
JCR impact factor
1.412 (2012)
JCR rank
27/117 (2012)
JCR quartile
1 (2012)
ISSN
0006-341X
DOI
10.1111/j.1541-0420.2012.01750.x
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2043181
handle
http://hdl.handle.net/1854/LU-2043181
date created
2012-02-24 00:21:47
date last changed
2013-04-16 13:17:09
@article{2043181,
  abstract     = {We present an adaptive percentile modified Wilcoxon rank sum test for the two-sample problem. The test is basically a Wilcoxon rank sum test applied on a fraction of the sample observations, and the fraction is adaptively determined by the sample observations. Most of the theory is developed under a location-shift model, but we demonstrate that the test is also meaningful for testing against more general alternatives. The test may be particularly useful for the analysis of massive datasets in which quasi-automatic hypothesis testing is required. We investigate the power characteristics of the new test in a simulation study, and we apply the test to a microarray experiment on colorectal cancer. These empirical studies demonstrate that the new test has good overall power and that it succeeds better in finding differentially expressed genes as compared to other popular tests. We conclude that the new nonparametric test is widely applicable and that its power is comparable to the power of the Baumgartner-Wei{\ss}-Schindler test.},
  author       = {Thas, Olivier and Clement, Lieven and Rayner, John and Carvalho, Beatriz and Van Criekinge, Wim},
  issn         = {0006-341X},
  journal      = {BIOMETRICS},
  keyword      = {CARCINOMA PROGRESSION,Adaptive test,PUTATIVE ONCOGENES,COLORECTAL ADENOMA,ONE-SAMPLE,Wilcoxon rank sum test,Location-shift,Baumgartner-Wei{\ss}-Schindler test,Differential gene expression,STATISTICS,CANCER},
  language     = {eng},
  number       = {2},
  pages        = {446--454},
  title        = {An omnibus consistent adaptive percentile modified Wilcoxon rank sum test with applications in gene expression studies},
  url          = {http://dx.doi.org/10.1111/j.1541-0420.2012.01750.x},
  volume       = {68},
  year         = {2012},
}

Chicago
Thas, Olivier, Lieven Clement, John Rayner, Beatriz Carvalho, and Wim Van Criekinge. 2012. “An Omnibus Consistent Adaptive Percentile Modified Wilcoxon Rank Sum Test with Applications in Gene Expression Studies.” Biometrics 68 (2): 446–454.
APA
Thas, O., Clement, L., Rayner, J., Carvalho, B., & Van Criekinge, W. (2012). An omnibus consistent adaptive percentile modified Wilcoxon rank sum test with applications in gene expression studies. BIOMETRICS, 68(2), 446–454.
Vancouver
1.
Thas O, Clement L, Rayner J, Carvalho B, Van Criekinge W. An omnibus consistent adaptive percentile modified Wilcoxon rank sum test with applications in gene expression studies. BIOMETRICS. 2012;68(2):446–54.
MLA
Thas, Olivier, Lieven Clement, John Rayner, et al. “An Omnibus Consistent Adaptive Percentile Modified Wilcoxon Rank Sum Test with Applications in Gene Expression Studies.” BIOMETRICS 68.2 (2012): 446–454. Print.