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Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis

Wim Grunewald UGent, Ive De Smet UGent, Daniel R Lewis, Christian Löfke, Leentje Jansen UGent, Geert Goeminne UGent, Robin Vanden Bossche UGent, Mansour Karimi UGent, Bert De Rybel UGent and Bartel Vanholme UGent, et al. (2012) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109(5). p.1554-1559
abstract
Gradients of the plant hormone auxin, which depend on its active intercellular transport, are crucial for the maintenance of root meristematic activity. This directional transport is largely orchestrated by a complex interaction of specific influx and efflux carriers that mediate the auxin flow into and out of cells, respectively. Besides these transport proteins, plant-specific polyphenolic compounds known as flavonols have been shown to act as endogenous regulators of auxin transport. However, only limited information is available on how flavonol synthesis is developmentally regulated. Using reduction-of-function and overexpression approaches in parallel, we demonstrate that the WRKY23 transcription factor is needed for proper root growth and development by stimulating the local biosynthesis of flavonols. The expression of WRKY23 itself is controlled by auxin through the AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 transcriptional response pathway. Our results suggest a model in which WRKY23 is part of a transcriptional feedback loop of auxin on its own transport through local regulation of flavonol biosynthesis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FAMILY, REGULATORS, CELLS, GENE, THALIANA, EXPRESSION, TRANSPORT, P-GLYCOPROTEINS, WRKY, lateral root, flavonoid, DIFFERENTIATION, LOCALIZATION
journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proc. Natl. Acad. Sci. U. S. A.
volume
109
issue
5
pages
6 pages
Web of Science type
Article
Web of Science id
000299731400046
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
9.737 (2012)
JCR rank
4/56 (2012)
JCR quartile
1 (2012)
ISSN
0027-8424
DOI
10.1073/pnas.1121134109
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2042405
handle
http://hdl.handle.net/1854/LU-2042405
date created
2012-02-23 13:54:51
date last changed
2014-05-26 10:01:24
@article{2042405,
  abstract     = {Gradients of the plant hormone auxin, which depend on its active intercellular transport, are crucial for the maintenance of root meristematic activity. This directional transport is largely orchestrated by a complex interaction of specific influx and efflux carriers that mediate the auxin flow into and out of cells, respectively. Besides these transport proteins, plant-specific polyphenolic compounds known as flavonols have been shown to act as endogenous regulators of auxin transport. However, only limited information is available on how flavonol synthesis is developmentally regulated. Using reduction-of-function and overexpression approaches in parallel, we demonstrate that the WRKY23 transcription factor is needed for proper root growth and development by stimulating the local biosynthesis of flavonols. The expression of WRKY23 itself is controlled by auxin through the AUXIN RESPONSE FACTOR 7 (ARF7) and ARF19 transcriptional response pathway. Our results suggest a model in which WRKY23 is part of a transcriptional feedback loop of auxin on its own transport through local regulation of flavonol biosynthesis.},
  author       = {Grunewald, Wim and De Smet, Ive and Lewis, Daniel R and L{\"o}fke, Christian and Jansen, Leentje and Goeminne, Geert and Vanden Bossche, Robin and Karimi, Mansour and De Rybel, Bert and Vanholme, Bartel and Teichmann, Thomas and Boerjan, Wout and Van Montagu, Marc and Gheysen, Godelieve and Muday, Gloria K and Friml, Jiri and Beeckman, Tom},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  keyword      = {FAMILY,REGULATORS,CELLS,GENE,THALIANA,EXPRESSION,TRANSPORT,P-GLYCOPROTEINS,WRKY,lateral root,flavonoid,DIFFERENTIATION,LOCALIZATION},
  language     = {eng},
  number       = {5},
  pages        = {1554--1559},
  title        = {Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis},
  url          = {http://dx.doi.org/10.1073/pnas.1121134109},
  volume       = {109},
  year         = {2012},
}

Chicago
Grunewald, Wim, Ive De Smet, Daniel R Lewis, Christian Löfke, Leentje Jansen, Geert Goeminne, Robin Vanden Bossche, et al. 2012. “Transcription Factor WRKY23 Assists Auxin Distribution Patterns During Arabidopsis Root Development Through Local Control on Flavonol Biosynthesis.” Proceedings of the National Academy of Sciences of the United States of America 109 (5): 1554–1559.
APA
Grunewald, W., De Smet, I., Lewis, D. R., Löfke, C., Jansen, L., Goeminne, G., Vanden Bossche, R., et al. (2012). Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(5), 1554–1559.
Vancouver
1.
Grunewald W, De Smet I, Lewis DR, Löfke C, Jansen L, Goeminne G, et al. Transcription factor WRKY23 assists auxin distribution patterns during Arabidopsis root development through local control on flavonol biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(5):1554–9.
MLA
Grunewald, Wim, Ive De Smet, Daniel R Lewis, et al. “Transcription Factor WRKY23 Assists Auxin Distribution Patterns During Arabidopsis Root Development Through Local Control on Flavonol Biosynthesis.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109.5 (2012): 1554–1559. Print.