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Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome

Jefri Heyman UGent, Hilde Van Den Daele UGent, Kevin De Wit UGent, Véronique Boudolf UGent, Barbara Berckmans UGent, Aurine Verkest UGent, Claire Lessa Alvim Kamei UGent, Geert De Jaeger UGent, Csaba Koncz and Lieven De Veylder UGent (2011) PLANT CELL. 23(12). p.4394-4410
abstract
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction. To ensure correct cell cycle progression, accurate timing of APC/C activity is important, which is obtained through its association with both activating and inhibitory subunits. However, although the APC/C is highly conserved among eukaryotes, no APC/C inhibitors are known in plants. Recently, we have identified ULTRAVIOLET-B-INSENSITIVE4 (UVI4) as a plant-specific component of the APC/C. Here, we demonstrate that UVI4 uses conserved APC/C interaction motifs to counteract the activity of the CELL CYCLE SWITCH52 A1 (CCS52A1) activator subunit, inhibiting the turnover of the A-type cyclin CYCA2;3. UVI4 is expressed in an S phase-dependent fashion, likely through the action of E2F transcription factors. Correspondingly, uvi4 mutant plants failed to accumulate CYCA2; 3 during the S phase and prematurely exited the cell cycle, triggering the onset of the endocycle. We conclude that UVI4 regulates the temporal inactivation of APC/C during DNA replication, allowing CYCA2;3 to accumulate above the level required for entering mitosis, and thereby regulates the meristem size and plant growth rate.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
TRANSCRIPTIONAL REGULATION, ENDO-REDUPLICATION, DNA-REPLICATION, ENDOCYCLE ONSET, GENE-EXPRESSION, THALIANA ROOT, KEN-BOX, MEIOSIS-I, COMPLEX, CYCLE
journal title
PLANT CELL
Plant Cell
volume
23
issue
12
pages
4394 - 4410
Web of Science type
Article
Web of Science id
000299677700021
JCR category
PLANT SCIENCES
JCR impact factor
8.987 (2011)
JCR rank
5/189 (2011)
JCR quartile
1 (2011)
ISSN
1040-4651
DOI
10.1105/tpc.111.091793
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2042270
handle
http://hdl.handle.net/1854/LU-2042270
date created
2012-02-23 13:40:23
date last changed
2012-12-17 16:47:08
@article{2042270,
  abstract     = {The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction. To ensure correct cell cycle progression, accurate timing of APC/C activity is important, which is obtained through its association with both activating and inhibitory subunits. However, although the APC/C is highly conserved among eukaryotes, no APC/C inhibitors are known in plants. Recently, we have identified ULTRAVIOLET-B-INSENSITIVE4 (UVI4) as a plant-specific component of the APC/C. Here, we demonstrate that UVI4 uses conserved APC/C interaction motifs to counteract the activity of the CELL CYCLE SWITCH52 A1 (CCS52A1) activator subunit, inhibiting the turnover of the A-type cyclin CYCA2;3. UVI4 is expressed in an S phase-dependent fashion, likely through the action of E2F transcription factors. Correspondingly, uvi4 mutant plants failed to accumulate CYCA2; 3 during the S phase and prematurely exited the cell cycle, triggering the onset of the endocycle. We conclude that UVI4 regulates the temporal inactivation of APC/C during DNA replication, allowing CYCA2;3 to accumulate above the level required for entering mitosis, and thereby regulates the meristem size and plant growth rate.},
  author       = {Heyman, Jefri and Van Den Daele, Hilde and De Wit, Kevin and Boudolf, V{\'e}ronique and Berckmans, Barbara and Verkest, Aurine and Lessa Alvim Kamei, Claire and De Jaeger, Geert and Koncz, Csaba and De Veylder, Lieven},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {TRANSCRIPTIONAL REGULATION,ENDO-REDUPLICATION,DNA-REPLICATION,ENDOCYCLE ONSET,GENE-EXPRESSION,THALIANA ROOT,KEN-BOX,MEIOSIS-I,COMPLEX,CYCLE},
  language     = {eng},
  number       = {12},
  pages        = {4394--4410},
  title        = {Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome},
  url          = {http://dx.doi.org/10.1105/tpc.111.091793},
  volume       = {23},
  year         = {2011},
}

Chicago
Heyman, Jefri, Hilde Van Den Daele, Kevin De Wit, Véronique Boudolf, Barbara Berckmans, Aurine Verkest, Claire Lessa Alvim Kamei, Geert De Jaeger, Csaba Koncz, and Lieven De Veylder. 2011. “Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 Maintains Cell Division Activity by Temporal Inhibition of the Anaphase-promoting Complex/cyclosome.” Plant Cell 23 (12): 4394–4410.
APA
Heyman, J., Van Den Daele, H., De Wit, K., Boudolf, V., Berckmans, B., Verkest, A., Lessa Alvim Kamei, C., et al. (2011). Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome. PLANT CELL, 23(12), 4394–4410.
Vancouver
1.
Heyman J, Van Den Daele H, De Wit K, Boudolf V, Berckmans B, Verkest A, et al. Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome. PLANT CELL. 2011;23(12):4394–410.
MLA
Heyman, Jefri, Hilde Van Den Daele, Kevin De Wit, et al. “Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 Maintains Cell Division Activity by Temporal Inhibition of the Anaphase-promoting Complex/cyclosome.” PLANT CELL 23.12 (2011): 4394–4410. Print.