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Adverse drug reactions in older people : detection and prevention

Mirko Petrovic UGent, Tischa van der Cammen and Graziano Onder (2012) DRUGS & AGING. 29(6). p.453-462
abstract
Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug regimens and because age is associated with changes in pharmacokinetics and pharmacodynamics. The presentation of an ADR in older adults is often atypical, which further complicates its recognition. One potential strategy for improving recognition of ADRs is to identify those patients who are at risk of an ADR. The recently developed GerontoNet ADR Risk Score is a practical tool for identification of older patients who are at increased risk for an ADR and who may represent a target for interventions aimed at reducing ADRs. Provision of adequate education in the domain of clinical geriatric pharmacology can improve recognition of ADRs. Besides formal surveillance systems, built-in computer programs with electronic prescribing databases and clinical pharmacist involvement in patient care within multidisciplinary geriatric teams might help to minimize the occurrence of ADRs. In addition, a number of actions can be taken in hospitals to stimulate appropriate prescribing and to assure adequate communication between primary and hospital care. In older adults with complex medical problems and needs, a global evaluation obtained through a comprehensive geriatric assessment may be helpful in simplifying drug prescription and prioritizing pharmacological and healthcare needs, resulting in an improvement in quality of prescribing.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
NURSING-HOME RESIDENTS, INAPPROPRIATE MEDICATION USE, ELDERLY-PATIENTS, RISK-FACTORS, HOSPITALIZED-PATIENTS, MAJOR CAUSE, EVENTS, METAANALYSIS, POPULATION, ADMISSION
journal title
DRUGS & AGING
Drugs Aging
volume
29
issue
6
pages
453 - 462
Web of Science type
Review
Web of Science id
000305501200005
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
2.646 (2012)
JCR rank
101/259 (2012)
JCR quartile
2 (2012)
ISSN
1170-229X
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2041293
handle
http://hdl.handle.net/1854/LU-2041293
date created
2012-02-22 19:51:23
date last changed
2017-09-14 08:18:27
@article{2041293,
  abstract     = {Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug regimens and because age is associated with changes in pharmacokinetics and pharmacodynamics. 
The presentation of an ADR in older adults is often atypical, which further complicates its recognition. One potential strategy for improving recognition of ADRs is to identify those patients who are at risk of an ADR. The recently developed GerontoNet ADR Risk Score is a practical tool for identification of older patients who are at increased risk for an ADR and who may represent a target for interventions aimed at reducing ADRs. 
Provision of adequate education in the domain of clinical geriatric pharmacology can improve recognition of ADRs. Besides formal surveillance systems, built-in computer programs with electronic prescribing databases and clinical pharmacist involvement in patient care within multidisciplinary geriatric teams might help to minimize the occurrence of ADRs. In addition, a number of actions can be taken in hospitals to stimulate appropriate prescribing and to assure adequate communication between primary and hospital care. In older adults with complex medical problems and needs, a global evaluation obtained through a comprehensive geriatric assessment may be helpful in simplifying drug prescription and prioritizing pharmacological and healthcare needs, resulting in an improvement in quality of prescribing.},
  author       = {Petrovic, Mirko and van der Cammen, Tischa and Onder, Graziano},
  issn         = {1170-229X},
  journal      = {DRUGS \& AGING},
  keyword      = {NURSING-HOME RESIDENTS,INAPPROPRIATE MEDICATION USE,ELDERLY-PATIENTS,RISK-FACTORS,HOSPITALIZED-PATIENTS,MAJOR CAUSE,EVENTS,METAANALYSIS,POPULATION,ADMISSION},
  language     = {eng},
  number       = {6},
  pages        = {453--462},
  title        = {Adverse drug reactions in older people : detection and prevention},
  volume       = {29},
  year         = {2012},
}

Chicago
Petrovic, Mirko, Tischa van der Cammen, and Graziano Onder. 2012. “Adverse Drug Reactions in Older People : Detection and Prevention.” Drugs & Aging 29 (6): 453–462.
APA
Petrovic, M., van der Cammen, T., & Onder, G. (2012). Adverse drug reactions in older people : detection and prevention. DRUGS & AGING, 29(6), 453–462.
Vancouver
1.
Petrovic M, van der Cammen T, Onder G. Adverse drug reactions in older people : detection and prevention. DRUGS & AGING. 2012;29(6):453–62.
MLA
Petrovic, Mirko, Tischa van der Cammen, and Graziano Onder. “Adverse Drug Reactions in Older People : Detection and Prevention.” DRUGS & AGING 29.6 (2012): 453–462. Print.