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Adverse drug reactions in older people : detection and prevention

(2012) DRUGS & AGING. 29(6). p.453-462
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Organization
Abstract
Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug regimens and because age is associated with changes in pharmacokinetics and pharmacodynamics. The presentation of an ADR in older adults is often atypical, which further complicates its recognition. One potential strategy for improving recognition of ADRs is to identify those patients who are at risk of an ADR. The recently developed GerontoNet ADR Risk Score is a practical tool for identification of older patients who are at increased risk for an ADR and who may represent a target for interventions aimed at reducing ADRs. Provision of adequate education in the domain of clinical geriatric pharmacology can improve recognition of ADRs. Besides formal surveillance systems, built-in computer programs with electronic prescribing databases and clinical pharmacist involvement in patient care within multidisciplinary geriatric teams might help to minimize the occurrence of ADRs. In addition, a number of actions can be taken in hospitals to stimulate appropriate prescribing and to assure adequate communication between primary and hospital care. In older adults with complex medical problems and needs, a global evaluation obtained through a comprehensive geriatric assessment may be helpful in simplifying drug prescription and prioritizing pharmacological and healthcare needs, resulting in an improvement in quality of prescribing.
Keywords
NURSING-HOME RESIDENTS, INAPPROPRIATE MEDICATION USE, ELDERLY-PATIENTS, RISK-FACTORS, HOSPITALIZED-PATIENTS, MAJOR CAUSE, EVENTS, METAANALYSIS, POPULATION, ADMISSION

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Chicago
Petrovic, Mirko, Tischa van der Cammen, and Graziano Onder. 2012. “Adverse Drug Reactions in Older People : Detection and Prevention.” Drugs & Aging 29 (6): 453–462.
APA
Petrovic, M., van der Cammen, T., & Onder, G. (2012). Adverse drug reactions in older people : detection and prevention. DRUGS & AGING, 29(6), 453–462.
Vancouver
1.
Petrovic M, van der Cammen T, Onder G. Adverse drug reactions in older people : detection and prevention. DRUGS & AGING. 2012;29(6):453–62.
MLA
Petrovic, Mirko, Tischa van der Cammen, and Graziano Onder. “Adverse Drug Reactions in Older People : Detection and Prevention.” DRUGS & AGING 29.6 (2012): 453–462. Print.
@article{2041293,
  abstract     = {Adverse drug reactions (ADRs) in older adults are an important healthcare problem since they are frequently a cause of hospitalization, occur commonly during admission, and are an important cause of morbidity and mortality. Older adults are particularly susceptible to ADRs because they are usually on multiple drug regimens and because age is associated with changes in pharmacokinetics and pharmacodynamics. 
The presentation of an ADR in older adults is often atypical, which further complicates its recognition. One potential strategy for improving recognition of ADRs is to identify those patients who are at risk of an ADR. The recently developed GerontoNet ADR Risk Score is a practical tool for identification of older patients who are at increased risk for an ADR and who may represent a target for interventions aimed at reducing ADRs. 
Provision of adequate education in the domain of clinical geriatric pharmacology can improve recognition of ADRs. Besides formal surveillance systems, built-in computer programs with electronic prescribing databases and clinical pharmacist involvement in patient care within multidisciplinary geriatric teams might help to minimize the occurrence of ADRs. In addition, a number of actions can be taken in hospitals to stimulate appropriate prescribing and to assure adequate communication between primary and hospital care. In older adults with complex medical problems and needs, a global evaluation obtained through a comprehensive geriatric assessment may be helpful in simplifying drug prescription and prioritizing pharmacological and healthcare needs, resulting in an improvement in quality of prescribing.},
  author       = {Petrovic, Mirko and van der Cammen, Tischa and Onder, Graziano},
  issn         = {1170-229X},
  journal      = {DRUGS \& AGING},
  keyword      = {NURSING-HOME RESIDENTS,INAPPROPRIATE MEDICATION USE,ELDERLY-PATIENTS,RISK-FACTORS,HOSPITALIZED-PATIENTS,MAJOR CAUSE,EVENTS,METAANALYSIS,POPULATION,ADMISSION},
  language     = {eng},
  number       = {6},
  pages        = {453--462},
  title        = {Adverse drug reactions in older people : detection and prevention},
  volume       = {29},
  year         = {2012},
}

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