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Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure

Benedicte Descamps (UGent) , Pieter Vandemaele (UGent) , Harmen Reyngoudt (UGent) , Karel Deblaere (UGent) , Luc Leybaert (UGent) , Koen Paemeleire (UGent) and Eric Achten (UGent)
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Organization
Abstract
Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single- subject level using a recently described hemodynamic response function (HRF) fitting algorithm. Materials and Methods: Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF. Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness- of- fit (R-2 =0.9745 +/- 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P < 0.001) and had nearly disappeared for the 6-s ISI. Conclusion: Quantifying refractory effects in individuals was possible in 86.3% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.
Keywords
BOLD-fMRI, hemodynamic response, adaptation, refractory effects, single-subject quantification, PERIOD, DYNAMICS, MIGRAINE, DISEASE, EVENT-RELATED FMRI, FUNCTIONAL MRI, CORTICAL HYPEREXCITABILITY, RESPONSES, ADAPTATION, EPILEPSY

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MLA
Descamps, Benedicte, et al. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-Subject Level Using an Inverse Logit Fitting Procedure.” JOURNAL OF MAGNETIC RESONANCE IMAGING, vol. 35, no. 3, 2012, pp. 723–30, doi:10.1002/jmri.22868.
APA
Descamps, B., Vandemaele, P., Reyngoudt, H., Deblaere, K., Leybaert, L., Paemeleire, K., & Achten, E. (2012). Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure. JOURNAL OF MAGNETIC RESONANCE IMAGING, 35(3), 723–730. https://doi.org/10.1002/jmri.22868
Chicago author-date
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, Karel Deblaere, Luc Leybaert, Koen Paemeleire, and Eric Achten. 2012. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-Subject Level Using an Inverse Logit Fitting Procedure.” JOURNAL OF MAGNETIC RESONANCE IMAGING 35 (3): 723–30. https://doi.org/10.1002/jmri.22868.
Chicago author-date (all authors)
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, Karel Deblaere, Luc Leybaert, Koen Paemeleire, and Eric Achten. 2012. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-Subject Level Using an Inverse Logit Fitting Procedure.” JOURNAL OF MAGNETIC RESONANCE IMAGING 35 (3): 723–730. doi:10.1002/jmri.22868.
Vancouver
1.
Descamps B, Vandemaele P, Reyngoudt H, Deblaere K, Leybaert L, Paemeleire K, et al. Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure. JOURNAL OF MAGNETIC RESONANCE IMAGING. 2012;35(3):723–30.
IEEE
[1]
B. Descamps et al., “Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure,” JOURNAL OF MAGNETIC RESONANCE IMAGING, vol. 35, no. 3, pp. 723–730, 2012.
@article{2038288,
  abstract     = {{Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single- subject level using a recently described hemodynamic response function (HRF) fitting algorithm. 
Materials and Methods: Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF. 
Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness- of- fit (R-2 =0.9745 +/- 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P < 0.001) and had nearly disappeared for the 6-s ISI. 
Conclusion: Quantifying refractory effects in individuals was possible in 86.3% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.}},
  author       = {{Descamps, Benedicte and Vandemaele, Pieter and Reyngoudt, Harmen and Deblaere, Karel and Leybaert, Luc and Paemeleire, Koen and Achten, Eric}},
  issn         = {{1053-1807}},
  journal      = {{JOURNAL OF MAGNETIC RESONANCE IMAGING}},
  keywords     = {{BOLD-fMRI,hemodynamic response,adaptation,refractory effects,single-subject quantification,PERIOD,DYNAMICS,MIGRAINE,DISEASE,EVENT-RELATED FMRI,FUNCTIONAL MRI,CORTICAL HYPEREXCITABILITY,RESPONSES,ADAPTATION,EPILEPSY}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{723--730}},
  title        = {{Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure}},
  url          = {{http://doi.org/10.1002/jmri.22868}},
  volume       = {{35}},
  year         = {{2012}},
}

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