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Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure

Benedicte Descamps UGent, Pieter Vandemaele UGent, Harmen Reyngoudt UGent, Karel Deblaere UGent, Luc Leybaert UGent, Koen Paemeleire UGent and Eric Achten UGent (2012) JOURNAL OF MAGNETIC RESONANCE IMAGING. 35(3). p.723-730
abstract
Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single- subject level using a recently described hemodynamic response function (HRF) fitting algorithm. Materials and Methods: Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF. Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness- of- fit (R-2 =0.9745 +/- 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P < 0.001) and had nearly disappeared for the 6-s ISI. Conclusion: Quantifying refractory effects in individuals was possible in 86.3% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
BOLD-fMRI, hemodynamic response, adaptation, refractory effects, single-subject quantification, PERIOD, DYNAMICS, MIGRAINE, DISEASE, EVENT-RELATED FMRI, FUNCTIONAL MRI, CORTICAL HYPEREXCITABILITY, RESPONSES, ADAPTATION, EPILEPSY
journal title
JOURNAL OF MAGNETIC RESONANCE IMAGING
J. Magn. Reson. Imaging
volume
35
issue
3
pages
723 - 730
Web of Science type
Article
Web of Science id
000300690400031
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.566 (2012)
JCR rank
38/119 (2012)
JCR quartile
2 (2012)
ISSN
1053-1807
DOI
10.1002/jmri.22868
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2038288
handle
http://hdl.handle.net/1854/LU-2038288
date created
2012-02-20 13:03:06
date last changed
2012-09-21 14:51:25
@article{2038288,
  abstract     = {Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single- subject level using a recently described hemodynamic response function (HRF) fitting algorithm. 
Materials and Methods: Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF. 
Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness- of- fit (R-2 =0.9745 +/- 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P {\textlangle} 0.001) and had nearly disappeared for the 6-s ISI. 
Conclusion: Quantifying refractory effects in individuals was possible in 86.3\% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.},
  author       = {Descamps, Benedicte and Vandemaele, Pieter and Reyngoudt, Harmen and Deblaere, Karel and Leybaert, Luc and Paemeleire, Koen and Achten, Eric},
  issn         = {1053-1807},
  journal      = {JOURNAL OF MAGNETIC RESONANCE IMAGING},
  keyword      = {BOLD-fMRI,hemodynamic response,adaptation,refractory effects,single-subject quantification,PERIOD,DYNAMICS,MIGRAINE,DISEASE,EVENT-RELATED FMRI,FUNCTIONAL MRI,CORTICAL HYPEREXCITABILITY,RESPONSES,ADAPTATION,EPILEPSY},
  language     = {eng},
  number       = {3},
  pages        = {723--730},
  title        = {Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure},
  url          = {http://dx.doi.org/10.1002/jmri.22868},
  volume       = {35},
  year         = {2012},
}

Chicago
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, Karel Deblaere, Luc Leybaert, Koen Paemeleire, and Eric Achten. 2012. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-subject Level Using an Inverse Logit Fitting Procedure.” Journal of Magnetic Resonance Imaging 35 (3): 723–730.
APA
Descamps, B., Vandemaele, P., Reyngoudt, H., Deblaere, K., Leybaert, L., Paemeleire, K., & Achten, E. (2012). Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure. JOURNAL OF MAGNETIC RESONANCE IMAGING, 35(3), 723–730.
Vancouver
1.
Descamps B, Vandemaele P, Reyngoudt H, Deblaere K, Leybaert L, Paemeleire K, et al. Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure. JOURNAL OF MAGNETIC RESONANCE IMAGING. 2012;35(3):723–30.
MLA
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, et al. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-subject Level Using an Inverse Logit Fitting Procedure.” JOURNAL OF MAGNETIC RESONANCE IMAGING 35.3 (2012): 723–730. Print.