Advanced search
1 file | 472.61 KB

Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure

Benedicte Descamps (UGent) , Pieter Vandemaele (UGent) , Harmen Reyngoudt (UGent) , Karel Deblaere (UGent) , Luc Leybaert (UGent) , Koen Paemeleire (UGent) and Eric Achten (UGent)
Author
Organization
Abstract
Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single- subject level using a recently described hemodynamic response function (HRF) fitting algorithm. Materials and Methods: Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF. Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness- of- fit (R-2 =0.9745 +/- 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P < 0.001) and had nearly disappeared for the 6-s ISI. Conclusion: Quantifying refractory effects in individuals was possible in 86.3% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.
Keywords
BOLD-fMRI, hemodynamic response, adaptation, refractory effects, single-subject quantification, PERIOD, DYNAMICS, MIGRAINE, DISEASE, EVENT-RELATED FMRI, FUNCTIONAL MRI, CORTICAL HYPEREXCITABILITY, RESPONSES, ADAPTATION, EPILEPSY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 472.61 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, Karel Deblaere, Luc Leybaert, Koen Paemeleire, and Eric Achten. 2012. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-subject Level Using an Inverse Logit Fitting Procedure.” Journal of Magnetic Resonance Imaging 35 (3): 723–730.
APA
Descamps, B., Vandemaele, P., Reyngoudt, H., Deblaere, K., Leybaert, L., Paemeleire, K., & Achten, E. (2012). Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure. JOURNAL OF MAGNETIC RESONANCE IMAGING, 35(3), 723–730.
Vancouver
1.
Descamps B, Vandemaele P, Reyngoudt H, Deblaere K, Leybaert L, Paemeleire K, et al. Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure. JOURNAL OF MAGNETIC RESONANCE IMAGING. 2012;35(3):723–30.
MLA
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, et al. “Quantifying Hemodynamic Refractory BOLD Effects in Normal Subjects at the Single-subject Level Using an Inverse Logit Fitting Procedure.” JOURNAL OF MAGNETIC RESONANCE IMAGING 35.3 (2012): 723–730. Print.
@article{2038288,
  abstract     = {Purpose: To evaluate whether hemodynamic refractory effects provoked by repeated visual stimulation can be detected and quantified at the single- subject level using a recently described hemodynamic response function (HRF) fitting algorithm. 
Materials and Methods: Hemodynamic refractory effects were induced with an easily applicable functional MRI (fMRI) paradigm. A fitting method with inverse logit (IL) functions was applied to quantify net HRFs at the singlesubject level with three interstimulus intervals (ISI; 1, 2, and 6 s). The model yielded amplitude, latencies, and width for each HRF. 
Results: HRF fitting was possible in 44 of 51 healthy volunteers, with excellent goodness- of- fit (R-2 =0.9745 +/- 6 0.0241). Refractory effects were most pronounced for the 1-s ISI (P {\textlangle} 0.001) and had nearly disappeared for the 6-s ISI. 
Conclusion: Quantifying refractory effects in individuals was possible in 86.3\% of normal subjects using the IL fitting algorithm. This setup may be suitable to explore such effects in individual patients.},
  author       = {Descamps, Benedicte and Vandemaele, Pieter and Reyngoudt, Harmen and Deblaere, Karel and Leybaert, Luc and Paemeleire, Koen and Achten, Eric},
  issn         = {1053-1807},
  journal      = {JOURNAL OF MAGNETIC RESONANCE IMAGING},
  keyword      = {BOLD-fMRI,hemodynamic response,adaptation,refractory effects,single-subject quantification,PERIOD,DYNAMICS,MIGRAINE,DISEASE,EVENT-RELATED FMRI,FUNCTIONAL MRI,CORTICAL HYPEREXCITABILITY,RESPONSES,ADAPTATION,EPILEPSY},
  language     = {eng},
  number       = {3},
  pages        = {723--730},
  title        = {Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure},
  url          = {http://dx.doi.org/10.1002/jmri.22868},
  volume       = {35},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: