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Absence of haemodynamic refractory effects in patients with migraine without aura: an interictal fMRI study

Benedicte Descamps UGent, Pieter Vandemaele UGent, Harmen Reyngoudt UGent, Karel Deblaere UGent, Luc Leybaert UGent, Koen Paemeleire UGent and Eric Achten UGent (2011) CEPHALALGIA. 31(11). p.1220-1231
abstract
Background: In healthy controls, haemodynamic refractory effects are observed with blood-oxygenation-level dependent (BOLD) functional MRI (fMRI): the haemodynamic response function (HRF) to the second stimulus in a pair of stimuli with short interstimulus interval (ISI) shows a decreased amplitude and an increased time-to-peak. We hypothesize that there may be interictal haemodynamic abnormalities in migraineurs. Methods: An event-related fMRI design with paired face stimuli and varying ISIs was used to measure interictal HRFs in the face recognition area of patients with migraine without aura (MwoA) and controls. Net responses to the second stimulus in a pair were calculated and averaged per participant. Several characterizing parameters of the net responses were quantified and examined within each group. Results: Refractory effects were not observed in our patient group. There are no changes in the net responses compared with the reference situation in patients, irrespective of the ISI, whereas in controls all HRF parameters are decreased or delayed for an ISI of 1 second. Conclusion: This is the first fMRI study investigating the haemodynamic refractory effects in MwoA patients. Unlike in controls, these effects are not observed in migraineurs. Although currently unclear, it is tempting to speculate that this observation reflects the neurovascular correlate of lack of habituation measured with evoked potentials in migraineurs.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
interictal, BRAIN, RESPONSES, Migraine without aura, BOLD-fMRI, haemodynamic refractory effects, CEREBROVASCULAR CO2 REACTIVITY, TENSION-TYPE HEADACHE, FUNCTIONAL MRI-BOLD, TRANSCRANIAL DOPPLER, WORKING-MEMORY LOAD, EVOKED-POTENTIALS, BLOOD-VOLUME, STIMULATION
journal title
CEPHALALGIA
Cephalalgia
volume
31
issue
11
pages
1220 - 1231
Web of Science type
Article
Web of Science id
000293597100008
JCR category
CLINICAL NEUROLOGY
JCR impact factor
3.43 (2011)
JCR rank
44/190 (2011)
JCR quartile
1 (2011)
ISSN
0333-1024
DOI
10.1177/0333102411415881
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2038287
handle
http://hdl.handle.net/1854/LU-2038287
date created
2012-02-20 12:57:30
date last changed
2012-06-04 10:44:49
@article{2038287,
  abstract     = {Background: In healthy controls, haemodynamic refractory effects are observed with blood-oxygenation-level dependent (BOLD) functional MRI (fMRI): the haemodynamic response function (HRF) to the second stimulus in a pair of stimuli with short interstimulus interval (ISI) shows a decreased amplitude and an increased time-to-peak. We hypothesize that there may be interictal haemodynamic abnormalities in migraineurs. 
Methods: An event-related fMRI design with paired face stimuli and varying ISIs was used to measure interictal HRFs in the face recognition area of patients with migraine without aura (MwoA) and controls. Net responses to the second stimulus in a pair were calculated and averaged per participant. Several characterizing parameters of the net responses were quantified and examined within each group. 
Results: Refractory effects were not observed in our patient group. There are no changes in the net responses compared with the reference situation in patients, irrespective of the ISI, whereas in controls all HRF parameters are decreased or delayed for an ISI of 1 second. 
Conclusion: This is the first fMRI study investigating the haemodynamic refractory effects in MwoA patients. Unlike in controls, these effects are not observed in migraineurs. Although currently unclear, it is tempting to speculate that this observation reflects the neurovascular correlate of lack of habituation measured with evoked potentials in migraineurs.},
  author       = {Descamps, Benedicte and Vandemaele, Pieter and Reyngoudt, Harmen and Deblaere, Karel and Leybaert, Luc and Paemeleire, Koen and Achten, Eric},
  issn         = {0333-1024},
  journal      = {CEPHALALGIA},
  keyword      = {interictal,BRAIN,RESPONSES,Migraine without aura,BOLD-fMRI,haemodynamic refractory effects,CEREBROVASCULAR CO2 REACTIVITY,TENSION-TYPE HEADACHE,FUNCTIONAL MRI-BOLD,TRANSCRANIAL DOPPLER,WORKING-MEMORY LOAD,EVOKED-POTENTIALS,BLOOD-VOLUME,STIMULATION},
  language     = {eng},
  number       = {11},
  pages        = {1220--1231},
  title        = {Absence of haemodynamic refractory effects in patients with migraine without aura: an interictal fMRI study},
  url          = {http://dx.doi.org/10.1177/0333102411415881},
  volume       = {31},
  year         = {2011},
}

Chicago
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, Karel Deblaere, Luc Leybaert, Koen Paemeleire, and Eric Achten. 2011. “Absence of Haemodynamic Refractory Effects in Patients with Migraine Without Aura: An Interictal fMRI Study.” Cephalalgia 31 (11): 1220–1231.
APA
Descamps, B., Vandemaele, P., Reyngoudt, H., Deblaere, K., Leybaert, L., Paemeleire, K., & Achten, E. (2011). Absence of haemodynamic refractory effects in patients with migraine without aura: an interictal fMRI study. CEPHALALGIA, 31(11), 1220–1231.
Vancouver
1.
Descamps B, Vandemaele P, Reyngoudt H, Deblaere K, Leybaert L, Paemeleire K, et al. Absence of haemodynamic refractory effects in patients with migraine without aura: an interictal fMRI study. CEPHALALGIA. 2011;31(11):1220–31.
MLA
Descamps, Benedicte, Pieter Vandemaele, Harmen Reyngoudt, et al. “Absence of Haemodynamic Refractory Effects in Patients with Migraine Without Aura: An Interictal fMRI Study.” CEPHALALGIA 31.11 (2011): 1220–1231. Print.