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Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation

Tom Claes (UGent) , Wim Bogaerts (UGent) and Peter Bienstman (UGent)
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Center for nano- and biophotonics (NB-Photonics)
Abstract
Recently, cheap silicon-on-insulator label-free ring resonator biosensors have been demonstrated that allow fast and accurate quantitative detection of biologically relevant molecules for applications in medical diagnostics and drug development. However, a further improvement of their detection limit is limited by their small sensitivity and an expensive tunable laser is typically required to resolve the sharp resonances for wavelength interrogation. Therefore, we experimentally investigated the use of a Vernier-cascade sensor that achieves a sensitivity (thousands of nm/RIU) that is an order of magnitude larger than that of a ring resonator sensor (approx. 100 nm/RIU), while still maintaining sharp spectral features that allow precise monitoring of spectral shifts with data-fitting. Moreover we prove that it's also possible to accurately interrogate the sensor with a low-cost broadband light source by integrating it with an arrayed waveguide grating spectral filter that divides the sensor's transmission spectrum in multiple wavelength channels and transmits them to spatially separated output ports. Experiments show that this sensor can monitor refractive index changes of watery solutions in real-time with a detection limit (1.6 . 10(-5) RIU) competitive with more expensive interrogation schemes, indicating its applicability in low-cost label-free biosensing.
Keywords
ON-INSULATOR, RING RESONATORS, CIRCUITS, SENSOR, ARRAY, silicon, label-free biosensing, ring resonator, Vernier, low-cost interrogation

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Citation

Please use this url to cite or link to this publication:

MLA
Claes, Tom, Wim Bogaerts, and Peter Bienstman. “Vernier-cascade Silicon Photonic Label-free Biosensor with Very Large Sensitivity and Low-cost Interrogation.” Proceedings of Spie, the International Society for Optical Engineering. Ed. H Mohseni, MH Agahi, & M Razeghi. Vol. 8099. Bellingham, WA, USA: SPIE, 2011. Print.
APA
Claes, T., Bogaerts, W., & Bienstman, P. (2011). Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation. In H. Mohseni, M. Agahi, & M. Razeghi (Eds.), PROCEEDINGS OF SPIE, THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING (Vol. 8099). Presented at the Conference on Biosensing and Nanomedicine IV, Bellingham, WA, USA: SPIE.
Chicago author-date
Claes, Tom, Wim Bogaerts, and Peter Bienstman. 2011. “Vernier-cascade Silicon Photonic Label-free Biosensor with Very Large Sensitivity and Low-cost Interrogation.” In Proceedings of Spie, the International Society for Optical Engineering, ed. H Mohseni, MH Agahi, and M Razeghi. Vol. 8099. Bellingham, WA, USA: SPIE.
Chicago author-date (all authors)
Claes, Tom, Wim Bogaerts, and Peter Bienstman. 2011. “Vernier-cascade Silicon Photonic Label-free Biosensor with Very Large Sensitivity and Low-cost Interrogation.” In Proceedings of Spie, the International Society for Optical Engineering, ed. H Mohseni, MH Agahi, and M Razeghi. Vol. 8099. Bellingham, WA, USA: SPIE.
Vancouver
1.
Claes T, Bogaerts W, Bienstman P. Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation. In: Mohseni H, Agahi M, Razeghi M, editors. PROCEEDINGS OF SPIE, THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING. Bellingham, WA, USA: SPIE; 2011.
IEEE
[1]
T. Claes, W. Bogaerts, and P. Bienstman, “Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation,” in PROCEEDINGS OF SPIE, THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, San Diego, CA, USA, 2011, vol. 8099.
@inproceedings{2036632,
  abstract     = {Recently, cheap silicon-on-insulator label-free ring resonator biosensors have been demonstrated that allow fast and accurate quantitative detection of biologically relevant molecules for applications in medical diagnostics and drug development. However, a further improvement of their detection limit is limited by their small sensitivity and an expensive tunable laser is typically required to resolve the sharp resonances for wavelength interrogation. Therefore, we experimentally investigated the use of a Vernier-cascade sensor that achieves a sensitivity (thousands of nm/RIU) that is an order of magnitude larger than that of a ring resonator sensor (approx. 100 nm/RIU), while still maintaining sharp spectral features that allow precise monitoring of spectral shifts with data-fitting. Moreover we prove that it's also possible to accurately interrogate the sensor with a low-cost broadband light source by integrating it with an arrayed waveguide grating spectral filter that divides the sensor's transmission spectrum in multiple wavelength channels and transmits them to spatially separated output ports. Experiments show that this sensor can monitor refractive index changes of watery solutions in real-time with a detection limit (1.6 . 10(-5) RIU) competitive with more expensive interrogation schemes, indicating its applicability in low-cost label-free biosensing.},
  articleno    = {80990R},
  author       = {Claes, Tom and Bogaerts, Wim and Bienstman, Peter},
  booktitle    = {PROCEEDINGS OF SPIE, THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING},
  editor       = {Mohseni, H and Agahi, MH and Razeghi, M},
  isbn         = {9780819487094},
  issn         = {0277-786X},
  keywords     = {ON-INSULATOR,RING RESONATORS,CIRCUITS,SENSOR,ARRAY,silicon,label-free biosensing,ring resonator,Vernier,low-cost interrogation},
  language     = {eng},
  location     = {San Diego, CA, USA},
  pages        = {8},
  publisher    = {SPIE},
  title        = {Vernier-cascade silicon photonic label-free biosensor with very large sensitivity and low-cost interrogation},
  url          = {http://dx.doi.org/10.1117/12.891818},
  volume       = {8099},
  year         = {2011},
}

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