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Fetal microchimeric cells in blood and thyroid glands of women with an autoimmune thyroid disease

Trees Lepez (UGent) , Mado Vandewoestyne (UGent) and Dieter Deforce (UGent)
(2012) CHIMERISM. 3(1). p.21-23
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Abstract
Persistence of fetal microchimeric cells may result in the development of autoimmune thyroid diseases (AITD) such as Hashimoto thyroiditis (HT) or Graves disease (GD). In women, HT and GD show an increased incidence in the years following parturition. Although fetal cells have already been shown to be more common in the thyroid glands of patients with an AITD compared with controls, these cells haven’t been described in blood of these patients. Our study detected fetal cells in blood of all patients with an AITD. Moreover, fetal cells were immune cells potentially capable of initiating a graft vs. host reaction and suggest a potential role of these cells in the pathogenesis of AITD. Our study indicates the value and need for further research in this field.
Keywords
Hashimoto's thyroiditis, Autoimmune thyroid disease, Graves' disease, FISH, real-time PCR

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Citation

Please use this url to cite or link to this publication:

Chicago
Lepez, Trees, Mado Vandewoestyne, and Dieter Deforce. 2012. “Fetal Microchimeric Cells in Blood and Thyroid Glands of Women with an Autoimmune Thyroid Disease.” Chimerism 3 (1): 21–23.
APA
Lepez, T., Vandewoestyne, M., & Deforce, D. (2012). Fetal microchimeric cells in blood and thyroid glands of women with an autoimmune thyroid disease. CHIMERISM, 3(1), 21–23.
Vancouver
1.
Lepez T, Vandewoestyne M, Deforce D. Fetal microchimeric cells in blood and thyroid glands of women with an autoimmune thyroid disease. CHIMERISM. 2012;3(1):21–3.
MLA
Lepez, Trees, Mado Vandewoestyne, and Dieter Deforce. “Fetal Microchimeric Cells in Blood and Thyroid Glands of Women with an Autoimmune Thyroid Disease.” CHIMERISM 3.1 (2012): 21–23. Print.
@article{2034014,
  abstract     = {Persistence of fetal microchimeric cells may result in the development of autoimmune thyroid diseases (AITD) such as Hashimoto thyroiditis (HT) or Graves disease (GD). In women, HT and GD show an increased incidence in the years following parturition. Although fetal cells have already been shown to be more common in the thyroid glands of patients with an AITD compared with controls, these cells haven{\textquoteright}t been described in blood of these patients. Our study detected fetal cells in blood of all patients with an AITD. Moreover, fetal cells were immune cells potentially capable of initiating a graft vs. host reaction and suggest a potential role of these cells in the pathogenesis of AITD. Our study indicates the value and need for further research in this field.},
  author       = {Lepez, Trees and Vandewoestyne, Mado and Deforce, Dieter},
  issn         = {1938-1956},
  journal      = {CHIMERISM},
  keyword      = {Hashimoto's thyroiditis,Autoimmune thyroid disease,Graves' disease,FISH,real-time PCR},
  language     = {eng},
  number       = {1},
  pages        = {21--23},
  title        = {Fetal microchimeric cells in blood and thyroid glands of women with an autoimmune thyroid disease},
  url          = {http://dx.doi.org/10.4161/chim.19615},
  volume       = {3},
  year         = {2012},
}

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