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Hydrogel network formation revised: high-resolution magic angle spinning nuclear magnetic resonance as a powerful tool for measuring absolute hydrogel cross-link efficiencies

Sandra Van Vlierberghe UGent, Bernd Fritzinger UGent, José Martins UGent and Peter Dubruel UGent (2010) APPLIED SPECTROSCOPY. 64(10). p.1176-1180
abstract
In the present work, high-resolution magic angle spinning (hr-MAS) NMR spectroscopy is applied as a straightforward nondestructive technique to quantify unreacted methacrylamide functionalities in cross-linked gelatin hydrogels. By adjusting several cross-linking parameters including the ultraviolet (UV) irradiation time and the photo-initiator concentration, the cross-linking degree can be easily varied. Remarkably, under all experimental conditions typically applied for hydrogel development, no more than 40% of the methacrylamide moieties present have reacted. The hr-MAS based approach to determine the cross-linking efficiency is shown to provide an innovative and more convenient alternative to the well-established classical techniques. In addition, the results obtained are in good correlation with mechanical analysis data.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
IRRADIATION, XANTHAN, CRYOGELS, RELEASE, SYSTEM, MAS NMR-SPECTROSCOPY, TISSUE, Gelatin, Cross-linking efficiency, NMR, High-resolution magic angle spinning nuclear magnetic resonance spectroscopy, hr-MAS NMR, IMPLANT
journal title
APPLIED SPECTROSCOPY
Appl. Spectrosc.
volume
64
issue
10
pages
1176 - 1180
Web of Science type
Article
Web of Science id
000282855500015
JCR category
INSTRUMENTS & INSTRUMENTATION
JCR impact factor
1.729 (2010)
JCR rank
15/61 (2010)
JCR quartile
1 (2010)
ISSN
0003-7028
DOI
10.1366/000370210792973550
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2033255
handle
http://hdl.handle.net/1854/LU-2033255
date created
2012-02-15 11:21:50
date last changed
2012-07-06 10:44:12
@article{2033255,
  abstract     = {In the present work, high-resolution magic angle spinning (hr-MAS) NMR spectroscopy is applied as a straightforward nondestructive technique to quantify unreacted methacrylamide functionalities in cross-linked gelatin hydrogels. By adjusting several cross-linking parameters including the ultraviolet (UV) irradiation time and the photo-initiator concentration, the cross-linking degree can be easily varied. Remarkably, under all experimental conditions typically applied for hydrogel development, no more than 40\% of the methacrylamide moieties present have reacted. The hr-MAS based approach to determine the cross-linking efficiency is shown to provide an innovative and more convenient alternative to the well-established classical techniques. In addition, the results obtained are in good correlation with mechanical analysis data.},
  author       = {Van Vlierberghe, Sandra and Fritzinger, Bernd and Martins, Jos{\'e} and Dubruel, Peter},
  issn         = {0003-7028},
  journal      = {APPLIED SPECTROSCOPY},
  keyword      = {IRRADIATION,XANTHAN,CRYOGELS,RELEASE,SYSTEM,MAS NMR-SPECTROSCOPY,TISSUE,Gelatin,Cross-linking efficiency,NMR,High-resolution magic angle spinning nuclear magnetic resonance spectroscopy,hr-MAS NMR,IMPLANT},
  language     = {eng},
  number       = {10},
  pages        = {1176--1180},
  title        = {Hydrogel network formation revised: high-resolution magic angle spinning nuclear magnetic resonance as a powerful tool for measuring absolute hydrogel cross-link efficiencies},
  url          = {http://dx.doi.org/10.1366/000370210792973550},
  volume       = {64},
  year         = {2010},
}

Chicago
Van Vlierberghe, Sandra, Bernd Fritzinger, José Martins, and Peter Dubruel. 2010. “Hydrogel Network Formation Revised: High-resolution Magic Angle Spinning Nuclear Magnetic Resonance as a Powerful Tool for Measuring Absolute Hydrogel Cross-link Efficiencies.” Applied Spectroscopy 64 (10): 1176–1180.
APA
Van Vlierberghe, S., Fritzinger, B., Martins, J., & Dubruel, P. (2010). Hydrogel network formation revised: high-resolution magic angle spinning nuclear magnetic resonance as a powerful tool for measuring absolute hydrogel cross-link efficiencies. APPLIED SPECTROSCOPY, 64(10), 1176–1180.
Vancouver
1.
Van Vlierberghe S, Fritzinger B, Martins J, Dubruel P. Hydrogel network formation revised: high-resolution magic angle spinning nuclear magnetic resonance as a powerful tool for measuring absolute hydrogel cross-link efficiencies. APPLIED SPECTROSCOPY. 2010;64(10):1176–80.
MLA
Van Vlierberghe, Sandra, Bernd Fritzinger, José Martins, et al. “Hydrogel Network Formation Revised: High-resolution Magic Angle Spinning Nuclear Magnetic Resonance as a Powerful Tool for Measuring Absolute Hydrogel Cross-link Efficiencies.” APPLIED SPECTROSCOPY 64.10 (2010): 1176–1180. Print.