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Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus

(1993) VACCINE. 11(12). p.1185-1187
Author
Organization
Abstract
Balb/c mice were immunized with 2 x 2 mug of purified recombinant secreted haemagglutinin, derived from the A/Victoria/3/75 (H3N2) virus. In the first immunization, Ribi adjuvant was used, while for the booster injection a monophosphoryl lipid A/muramyl dipeptide combination was chosen. Mice immunized in this way were 90-100% protected against a challenge with 20 LD50 of mouse-adapted, homologous virus (strain X47). Bromelain-solubilized haemagglutinin gave only 70% protection under comparable conditions.
Keywords
HEMAGGLUTININ, INFLUENZA VIRUS, RECOMBINANT, PROTECTION, RIBI ADJUVANT, VACCINE, A H1N1, HEMAGGLUTININ, GENE, HA

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Citation

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MLA
Vanlandschoot, Peter, Geert Maertens, Willy Min Jou, et al. “Recombinant Secreted Haemagglutinin Protects Mice Against a Lethal Challenge of Influenza Virus.” VACCINE 11.12 (1993): 1185–1187. Print.
APA
Vanlandschoot, P., Maertens, G., Min Jou, W., & Fiers, W. (1993). Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus. VACCINE, 11(12), 1185–1187.
Chicago author-date
Vanlandschoot, Peter, Geert Maertens, Willy Min Jou, and Walter Fiers. 1993. “Recombinant Secreted Haemagglutinin Protects Mice Against a Lethal Challenge of Influenza Virus.” Vaccine 11 (12): 1185–1187.
Chicago author-date (all authors)
Vanlandschoot, Peter, Geert Maertens, Willy Min Jou, and Walter Fiers. 1993. “Recombinant Secreted Haemagglutinin Protects Mice Against a Lethal Challenge of Influenza Virus.” Vaccine 11 (12): 1185–1187.
Vancouver
1.
Vanlandschoot P, Maertens G, Min Jou W, Fiers W. Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus. VACCINE. 1993;11(12):1185–7.
IEEE
[1]
P. Vanlandschoot, G. Maertens, W. Min Jou, and W. Fiers, “Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus,” VACCINE, vol. 11, no. 12, pp. 1185–1187, 1993.
@article{203219,
  abstract     = {Balb/c mice were immunized with 2 x 2 mug of purified recombinant secreted haemagglutinin, derived from the A/Victoria/3/75 (H3N2) virus. In the first immunization, Ribi adjuvant was used, while for the booster injection a monophosphoryl lipid A/muramyl dipeptide combination was chosen. Mice immunized in this way were 90-100% protected against a challenge with 20 LD50 of mouse-adapted, homologous virus (strain X47). Bromelain-solubilized haemagglutinin gave only 70% protection under comparable conditions.},
  author       = {Vanlandschoot, Peter and Maertens, Geert and Min Jou, Willy and Fiers, Walter},
  issn         = {0264-410X},
  journal      = {VACCINE},
  keywords     = {HEMAGGLUTININ,INFLUENZA VIRUS,RECOMBINANT,PROTECTION,RIBI ADJUVANT,VACCINE,A H1N1,HEMAGGLUTININ,GENE,HA},
  language     = {eng},
  number       = {12},
  pages        = {1185--1187},
  title        = {Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus},
  url          = {http://dx.doi.org/10.1016/0264-410X(93)90040-5},
  volume       = {11},
  year         = {1993},
}

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