Advanced search

The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study

(2012) EUROPEAN RESPIRATORY JOURNAL. 40(2). p.298-305
Author
Organization
Abstract
The GOLD classification of COPD does not always matches with other clinical disease descriptors such as exacerbation frequency and quality of life indicating that FEV1 is not a perfect descriptor of the disease. The aim of this study was to see whether changes in airway geometry after inhalation of the most commonly used inhalation therapy in severe COPD can more adequately be described with an imaged based approach then with spirometry. A total of 10 COPD GOLD III patients was assessed in a double blind cross over study. Airway volumes were analysed using segmentation of the MSCT images, airway resistance was determined using computational fluid dynamics (CFD). Results showed that distal airway volume significantly increased (p=0.011) in patients four hours after receiving budesonide/formoterol combination from 9.6±4.67cm3 to 10.14±4.81cm3. Also CFD-based airway resistance significantly decreased (p=0.047) from 0.051±0.021 kPas·l−1 to 0.043±0.019 kPas·l−1. None of the lung function parameters showed a significant change. Only FRC showed a trend to decline (p=0.056). Only the image-based parameters were able to predict the visit at which the combination product was administered. This study showed that imaging is a sensitive, complementary tool to describe changes in airway structure.
Keywords
inhalation treatment, lung function testing, imaging techniques in chronic obstructive pulmonary disease, AIRWAYS, MODELS, MORTALITY, Chronic obstructive pulmonary disease, HEALTH-STATUS, COMPUTATIONAL FLUID-DYNAMICS, OBSTRUCTIVE PULMONARY-DISEASE, TRIAL, FLUTICASONE PROPIONATE, SALMETEROL, FLOW

Citation

Please use this url to cite or link to this publication:

Chicago
De Backer, Lieve, Wim Vos, Jan De Backer, Cedric Van Holsbeke, Samir Vinchurkar, and Wilfried De Backer. 2012. “The Acute Effect of Budesonide/formoterol in COPD: a Multi-slice Computed Tomography and Lung Function Study.” European Respiratory Journal 40 (2): 298–305.
APA
De Backer, Lieve, Vos, W., De Backer, J., Van Holsbeke, C., Vinchurkar, S., & De Backer, W. (2012). The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study. EUROPEAN RESPIRATORY JOURNAL, 40(2), 298–305.
Vancouver
1.
De Backer L, Vos W, De Backer J, Van Holsbeke C, Vinchurkar S, De Backer W. The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study. EUROPEAN RESPIRATORY JOURNAL. 2012;40(2):298–305.
MLA
De Backer, Lieve, Wim Vos, Jan De Backer, et al. “The Acute Effect of Budesonide/formoterol in COPD: a Multi-slice Computed Tomography and Lung Function Study.” EUROPEAN RESPIRATORY JOURNAL 40.2 (2012): 298–305. Print.
@article{2028928,
  abstract     = {The GOLD classification of COPD does not always matches with other clinical disease descriptors such as exacerbation frequency and quality of life indicating that FEV1 is not a perfect descriptor of the disease. The aim of this study was to see whether changes in airway geometry after inhalation of the most commonly used inhalation therapy in severe COPD can more adequately be described with an imaged based approach then with spirometry. A total of 10 COPD GOLD III patients was assessed in a double blind cross over study. Airway volumes were analysed using segmentation of the MSCT images, airway resistance was determined using computational fluid dynamics (CFD). Results showed that distal airway volume significantly increased (p=0.011) in patients four hours after receiving budesonide/formoterol combination from 9.6{\textpm}4.67cm3 to 10.14{\textpm}4.81cm3. Also CFD-based airway resistance significantly decreased (p=0.047) from 0.051{\textpm}0.021 kPas{\textperiodcentered}l\ensuremath{-}1 to 0.043{\textpm}0.019 kPas{\textperiodcentered}l\ensuremath{-}1. None of the lung function parameters showed a significant change. Only FRC showed a trend to decline (p=0.056). Only the image-based parameters were able to predict the visit at which the combination product was administered. This study showed that imaging is a sensitive, complementary tool to describe changes in airway structure.},
  author       = {De Backer, Lieve and Vos, Wim and De Backer, Jan and Van Holsbeke, Cedric and Vinchurkar, Samir and De Backer, Wilfried},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keyword      = {inhalation treatment,lung function testing,imaging techniques in chronic obstructive pulmonary disease,AIRWAYS,MODELS,MORTALITY,Chronic obstructive pulmonary disease,HEALTH-STATUS,COMPUTATIONAL FLUID-DYNAMICS,OBSTRUCTIVE PULMONARY-DISEASE,TRIAL,FLUTICASONE PROPIONATE,SALMETEROL,FLOW},
  language     = {eng},
  number       = {2},
  pages        = {298--305},
  title        = {The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study},
  url          = {http://dx.doi.org/10.1183/\unmatched{200b}09031936.00072511},
  volume       = {40},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: