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A subject-specific fluid-structure interaction model of a lower airway using the nonrigid coherent point drift algorithm

Cedric Van Holsbeke UGent, Wim Vos, Jan De Backer, Samir Vinchurkar, Pascal Verdonck UGent and Wilfried De Backer (2012) Biomechanics and Biomedical Engineering, 10th International symposium, Abstracts.
abstract
Modeling human breathing using Fluid-Structure Interaction (FSI) is a challenging topic. Performing this in a subject-specific way is almost impossible as tissue properties and muscle interactions are very complex and vary a lot inter- and intra-subject. However, the problem can be inversed if the airway movement is known. Imaging modalities such as high resolution computed tomography (HRCT) scans make it possible to make a detailed anatomical model of the subject's airways. A HRCT at functional residual capacity (FRC) and at total lung capacity (TLC) gives the initial and the final geometry of a breathing cycle. Mapping the nodes of the TLC mesh to the nodes of the FRC mesh using a point set registration algorithm gives the transformation matrix of every node, resulting in a moving mesh which steers the flow. In this study, the nonrigid Coherent Point Drift Algorithm (CPD) is used. In CPD, the alignment of two node sets is considered as a probability density estimation problem and the Gaussian mixture model centroids (representing the TLC node set) is fitted to the FRC node set by maximizing the likelihood. Lower airway models of a healthy subject are reconstructed until the first generation of segmental airways at both TLC and FRC. The FRC model is then mapped to the TLC model using CPD. The volume difference between the mapped and the original model is 0.375% and the root mean square Hausdorff distance is 0.21mm. This initial study shows that CPD is a promising method in modeling the breathing movement.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
FSI, Coherent Point Drift, Lower airways
in
Biomechanics and Biomedical Engineering, 10th International symposium, Abstracts
conference name
10th International symposium on Biomechanics and Biomedical Engineering
conference location
Berlin, Germany
conference start
2012-04-11
conference end
2012-04-14
language
English
UGent publication?
yes
classification
C3
id
2028915
handle
http://hdl.handle.net/1854/LU-2028915
date created
2012-02-13 17:53:24
date last changed
2015-05-19 10:59:23
@inproceedings{2028915,
  abstract     = {Modeling human breathing using Fluid-Structure Interaction (FSI) is a challenging topic. Performing this in a subject-specific way is almost impossible as tissue properties and muscle interactions are very complex and vary a lot inter- and intra-subject. However, the problem can be inversed if the airway movement is known. Imaging modalities such as high resolution computed tomography (HRCT) scans make it possible to make a detailed anatomical model of the subject's airways. A HRCT at functional residual capacity (FRC) and at total lung capacity (TLC) gives the initial and the final geometry of a breathing cycle. Mapping the nodes of the TLC mesh to the nodes of the FRC mesh using a point set registration algorithm gives the transformation matrix of every node, resulting in a moving mesh which steers the flow. In this study, the nonrigid Coherent Point Drift Algorithm (CPD) is used. In CPD, the alignment of two node sets is considered as a probability density estimation problem and the Gaussian mixture model centroids (representing the TLC node set) is fitted to the FRC node set by maximizing the likelihood. Lower airway models of a healthy subject are reconstructed until the first generation of segmental airways at both TLC and FRC. The FRC model is then mapped to the TLC model using CPD. The volume difference between the mapped and the original model is 0.375\% and the root mean square Hausdorff distance is 0.21mm. This initial study shows that CPD is a promising method in modeling the breathing movement.},
  author       = {Van Holsbeke, Cedric and Vos, Wim and De Backer, Jan and Vinchurkar, Samir and Verdonck, Pascal and De Backer, Wilfried},
  booktitle    = {Biomechanics and Biomedical Engineering, 10th International symposium, Abstracts},
  keyword      = {FSI,Coherent Point Drift,Lower airways},
  language     = {eng},
  location     = {Berlin, Germany},
  title        = {A subject-specific fluid-structure interaction model of a lower airway using the nonrigid coherent point drift algorithm},
  year         = {2012},
}

Chicago
Van Holsbeke, Cedric, Wim Vos, Jan De Backer, Samir Vinchurkar, Pascal Verdonck, and Wilfried De Backer. 2012. “A Subject-specific Fluid-structure Interaction Model of a Lower Airway Using the Nonrigid Coherent Point Drift Algorithm.” In Biomechanics and Biomedical Engineering, 10th International Symposium, Abstracts.
APA
Van Holsbeke, C., Vos, W., De Backer, J., Vinchurkar, S., Verdonck, P., & De Backer, W. (2012). A subject-specific fluid-structure interaction model of a lower airway using the nonrigid coherent point drift algorithm. Biomechanics and Biomedical Engineering, 10th International symposium, Abstracts. Presented at the 10th International symposium on Biomechanics and Biomedical Engineering.
Vancouver
1.
Van Holsbeke C, Vos W, De Backer J, Vinchurkar S, Verdonck P, De Backer W. A subject-specific fluid-structure interaction model of a lower airway using the nonrigid coherent point drift algorithm. Biomechanics and Biomedical Engineering, 10th International symposium, Abstracts. 2012.
MLA
Van Holsbeke, Cedric, Wim Vos, Jan De Backer, et al. “A Subject-specific Fluid-structure Interaction Model of a Lower Airway Using the Nonrigid Coherent Point Drift Algorithm.” Biomechanics and Biomedical Engineering, 10th International Symposium, Abstracts. 2012. Print.