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In treated asthmatics, symptom scores better correlate with airway geometry than with Fev1

Wim Vos, Lieve De Backer, Annick Devolder, Cedric Van Holsbeke UGent, Jan De Backer, Samir Vinchurkar, Rita Claes and Wilfried De Backer (2011) American Thoracic Society international conference, Abstracts.
abstract
Asthma treatment can be guided by clinical symptoms, eNO and lung function. Recently it became possible to measure changes in airway caliber by performing airway segmentations starting from CT images (J. Biomech 2008;41:106-113). The aim of this study was to see how changes in airway caliber (imaged airway volume, iVaw) correlate with symptoms, eNO and spirometry. We studied 7 steroid naïve patients [2 M, 5F; age 51.8(8.7)y] before and after 6 months of combination therapy [fine particle beclomethasone-formoterol (Inuvair)]. At baseline the asthma symptom score (ASS) was 15.2 (5.0) and FEV1 was 93,3 (17,4)% pred. During the treatment the ASS significantly improved from 15.2(5.0) to 19.3(6.8), p=0.02. The correlations between the improvement in the ASS and the changes in airway volume and the changes in FEV1 after 6 months of treatment are investigated. It can be seen that changes in the ASS better (and significantly) correlate with the changes in iVaw measured with functional imaging than with the spirometric data (FEV1). Changes in iVaw also correlated significantly with the changes in eNO while such correlations could also not be found with FEV1. We conclude that measuring changes in iVaw may be worthwhile since they are more readily related the clinical outcomes then the spirometric data.
Please use this url to cite or link to this publication:
author
organization
year
type
conference
publication status
published
subject
keyword
Asthma, Inuvair, FEV1
in
American Thoracic Society international conference, Abstracts
conference name
American Thoracic Society 2011 International conference (ATS 2011)
conference location
Denver, Colorado
conference start
2011-05-13
conference end
2011-05-18
language
English
UGent publication?
no
classification
C3
id
2028856
handle
http://hdl.handle.net/1854/LU-2028856
date created
2012-02-13 17:43:30
date last changed
2012-03-06 14:09:28
@inproceedings{2028856,
  abstract     = {Asthma treatment can be guided by clinical symptoms, eNO and lung function. Recently it became possible to measure changes in airway caliber by performing airway segmentations starting from CT images (J. Biomech 2008;41:106-113). The aim of this study was to see how changes in airway caliber (imaged airway volume, iVaw) correlate with symptoms, eNO and spirometry. We studied 7 steroid na{\"i}ve patients [2 M, 5F; age 51.8(8.7)y] before and after 6 months of combination therapy [fine particle beclomethasone-formoterol (Inuvair)]. At baseline the asthma symptom score (ASS) was 15.2 (5.0) and FEV1 was 93,3 (17,4)\% pred. During the treatment the ASS significantly improved from 15.2(5.0) to 19.3(6.8), p=0.02. The correlations between the improvement in the ASS and the changes in airway volume and the changes in FEV1 after 6 months of treatment are investigated. It can be seen that changes in the ASS better (and significantly) correlate with the changes in iVaw measured with functional imaging than with the spirometric data (FEV1). Changes in iVaw also correlated significantly with the changes in eNO while such correlations could also not be found with FEV1. We conclude that measuring changes in iVaw may be worthwhile since they are more readily related the clinical outcomes then the spirometric data.},
  author       = {Vos, Wim and De Backer, Lieve and Devolder, Annick and Van Holsbeke, Cedric and De Backer, Jan and Vinchurkar, Samir and Claes, Rita and De Backer, Wilfried},
  booktitle    = {American Thoracic Society international conference, Abstracts},
  keyword      = {Asthma,Inuvair,FEV1},
  language     = {eng},
  location     = {Denver, Colorado},
  title        = {In treated asthmatics, symptom scores better correlate with airway geometry than with Fev1},
  year         = {2011},
}

Chicago
Vos, Wim, Lieve De Backer, Annick Devolder, Cedric Van Holsbeke, Jan De Backer, Samir Vinchurkar, Rita Claes, and Wilfried De Backer. 2011. “In Treated Asthmatics, Symptom Scores Better Correlate with Airway Geometry Than with Fev1.” In American Thoracic Society International Conference, Abstracts.
APA
Vos, Wim, De Backer, L., Devolder, A., Van Holsbeke, C., De Backer, J., Vinchurkar, S., Claes, R., et al. (2011). In treated asthmatics, symptom scores better correlate with airway geometry than with Fev1. American Thoracic Society international conference, Abstracts. Presented at the American Thoracic Society 2011 International conference (ATS 2011).
Vancouver
1.
Vos W, De Backer L, Devolder A, Van Holsbeke C, De Backer J, Vinchurkar S, et al. In treated asthmatics, symptom scores better correlate with airway geometry than with Fev1. American Thoracic Society international conference, Abstracts. 2011.
MLA
Vos, Wim, Lieve De Backer, Annick Devolder, et al. “In Treated Asthmatics, Symptom Scores Better Correlate with Airway Geometry Than with Fev1.” American Thoracic Society International Conference, Abstracts. 2011. Print.