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Elimination of interferences in the determination of arsenic and selenium in biological samples by inductively coupled plasma mass spectrometry

Jan Goossens UGent, Frank Vanhaecke UGent, Luc Moens UGent and Richard Dams UGent (1993) ANALYTICA CHIMICA ACTA. 280(1). p.137-143
abstract
The determination of As and Se in biological samples by inductively coupled plasma mass spectrometry is well known to be degraded by spectral interferences. The resolution of quadrupole mass analysers is insufficient to resolve As+ and Se' ions from polyatomic species such as ArCl+, ArAr+ and SO3+. A study of this problem in human serum also revealed substantial non-spectral interferences on these elements occurring in the presence of organic compounds. It is shown that both problems can easily be overcome by a combination of chemical modification (addition of 4% ethanol) with nebulizer flow-rate gas adjustment. Under these conditions the use of standard additions for calibration allowed As and Se to be determined accurately in samples of biological origin. The method developed was applied to human serum and urine and for both As and Se excellent agreement with certified values was obtained.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ARSENIC, INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY, BIOLOGICAL SAMPLES, INTERFERENCES, SELENIUM, URINE, POLYATOMIC ION INTERFERENCES, ICP-MS, INTERNAL STANDARDIZATION, CONCOMITANT ELEMENTS, HUMAN-SERUM, GAS, CHROMATOGRAPHY, SUPPRESSION, SIGNAL, ACID
journal title
ANALYTICA CHIMICA ACTA
Anal. Chim. Acta
volume
280
issue
1
pages
137 - 143
Web of Science type
Article
ISSN
0003-2670
DOI
10.1016/0003-2670(93)80251-F
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
202739
handle
http://hdl.handle.net/1854/LU-202739
date created
2004-01-14 13:42:00
date last changed
2012-11-26 11:17:12
@article{202739,
  abstract     = {The determination of As and Se in biological samples by inductively coupled plasma mass spectrometry is well known to be degraded by spectral interferences. The resolution of quadrupole mass analysers is insufficient to resolve As+ and Se' ions from polyatomic species such as ArCl+, ArAr+ and SO3+. A study of this problem in human serum also revealed substantial non-spectral interferences on these elements occurring in the presence of organic compounds. It is shown that both problems can easily be overcome by a combination of chemical modification (addition of 4\% ethanol) with nebulizer flow-rate gas adjustment. Under these conditions the use of standard additions for calibration allowed As and Se to be determined accurately in samples of biological origin. The method developed was applied to human serum and urine and for both As and Se excellent agreement with certified values was obtained.},
  author       = {Goossens, Jan and Vanhaecke, Frank and Moens, Luc and Dams, Richard},
  issn         = {0003-2670},
  journal      = {ANALYTICA CHIMICA ACTA},
  keyword      = {ARSENIC,INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY,BIOLOGICAL SAMPLES,INTERFERENCES,SELENIUM,URINE,POLYATOMIC ION INTERFERENCES,ICP-MS,INTERNAL STANDARDIZATION,CONCOMITANT ELEMENTS,HUMAN-SERUM,GAS,CHROMATOGRAPHY,SUPPRESSION,SIGNAL,ACID},
  language     = {eng},
  number       = {1},
  pages        = {137--143},
  title        = {Elimination of interferences in the determination of arsenic and selenium in biological samples by inductively coupled plasma mass spectrometry},
  url          = {http://dx.doi.org/10.1016/0003-2670(93)80251-F},
  volume       = {280},
  year         = {1993},
}

Chicago
Goossens, Jan, Frank Vanhaecke, Luc Moens, and Richard Dams. 1993. “Elimination of Interferences in the Determination of Arsenic and Selenium in Biological Samples by Inductively Coupled Plasma Mass Spectrometry.” Analytica Chimica Acta 280 (1): 137–143.
APA
Goossens, Jan, Vanhaecke, F., Moens, L., & Dams, R. (1993). Elimination of interferences in the determination of arsenic and selenium in biological samples by inductively coupled plasma mass spectrometry. ANALYTICA CHIMICA ACTA, 280(1), 137–143.
Vancouver
1.
Goossens J, Vanhaecke F, Moens L, Dams R. Elimination of interferences in the determination of arsenic and selenium in biological samples by inductively coupled plasma mass spectrometry. ANALYTICA CHIMICA ACTA. 1993;280(1):137–43.
MLA
Goossens, Jan, Frank Vanhaecke, Luc Moens, et al. “Elimination of Interferences in the Determination of Arsenic and Selenium in Biological Samples by Inductively Coupled Plasma Mass Spectrometry.” ANALYTICA CHIMICA ACTA 280.1 (1993): 137–143. Print.