Ghent University Academic Bibliography

Advanced

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Maria Soler Artigas, Daan W Loth, Louise V Wain, Sina A Gharib, Ma'en Obeidat, Wenbo Tang, Guangju Zhai, Jing Hua Zhao, Albert Vernon Smith, Jennifer E Huffman, et al. (2011) NATURE GENETICS. 43(11). p.1082-U70
abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
POLYMORPHISMS, POPULATION, OBSTRUCTIVE PULMONARY-DISEASE, GENETIC-VARIATION, BLOOD-PRESSURE, VARIANTS, METAANALYSIS, PROTEIN, RISK, EXPRESSION
journal title
NATURE GENETICS
Nature Genet.
volume
43
issue
11
pages
1082 - U70
Web of Science type
Article
Web of Science id
000296584000011
JCR category
GENETICS & HEREDITY
JCR impact factor
35.532 (2011)
JCR rank
2/155 (2011)
JCR quartile
1 (2011)
ISSN
1061-4036
DOI
10.1038/ng.941
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2025994
handle
http://hdl.handle.net/1854/LU-2025994
date created
2012-02-10 10:39:09
date last changed
2017-03-07 10:47:48
@article{2025994,
  abstract     = {Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P {\textlangle} 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.},
  author       = {Artigas, Maria Soler and Loth, Daan W and Wain, Louise V and Gharib, Sina A and Obeidat, Ma'en and Tang, Wenbo and Zhai, Guangju and Zhao, Jing Hua and Smith, Albert Vernon and Huffman, Jennifer E and Albrecht, Eva and Jackson, Catherine M and Evans, David M and Cadby, Gemma and Fornage, Myriam and Manichaikul, Ani and Lopez, Lorna M and Johnson, Toby and Aldrich, Melinda C and Aspelund, Thor and Barroso, Ines and Campbell, Harry and Cassano, Patricia A and Couper, David J and Eiriksdottir, Gudny and Franceschini, Nora and Garcia, Melissa and Gieger, Christian and Gislason, Gauti Kjartan and Grkovic, Ivica and Hammond, Christopher J and Hancock, Dana B and Harris, Tamara B and Ramasamy, Adaikalavan and Heckbert, Susan R and Heliovaara, Markku and Homuth, Georg and Hysi, Pirro G and James, Alan L and Jankovic, Stipan and Joubert, Bonnie R and Karrasch, Stefan and Klopp, Norman and Koch, Beate and Kritchevsky, Stephen B and Launer, Lenore J and Liu, Yongmei and Loehr, Laura R and Lohman, Kurt and Loos, Ruth JF and Lumley, Thomas and Al Balushi, Khalid A and Ang, Wei Q and Barr, R Graham and Beilby, John and Blakey, John D and Boban, Mladen and Boraska, Vesna and Brisman, Jonas and Britton, John R and Brusselle, Guy and Cooper, Cyrus and Curjuric, Ivan and Dahgam, Santosh and Deary, Ian J and Ebrahim, Shah and Eijgelsheim, Mark and Francks, Clyde and Gaysina, Darya and Granell, Raquel and Gu, Xiangjun and Hankinson, John L and Hardy, Rebecca and Harris, Sarah E and Henderson, John and Henry, Amanda and Hingorani, Aroon D and Hofman, Albert and Holt, Patrick G and Hui, Jennie and Hunter, Michael L and Imboden, Medea and Jameson, Karen A and Kerr, Shona M and Kolcic, Ivana and Kronenberg, Florian and Liu, Jason Z and Marchini, Jonathan and McKeever, Tricia and Morris, Andrew D and Olin, Anna-Carin and Porteous, David J and Postma, Dirkje S and Rich, Stephen S and Ring, Susan M and Rivadeneira, Fernando and Rochat, Thierry and Sayer, Avan Aihie and Sayers, Ian and Sly, Peter D and Smith, George Davey and Sood, Akshay and Starr, John M and Uitterlinden, Andre G and Vonk, Judith M and Wannamethee, S Goya and Whincup, Peter H and Wijmenga, Cisca and Williams, O Dale and Wong, Andrew and Mangino, Massimo and Marciante, Kristin D and McArdle, Wendy L and Meibohm, Bernd and Morrison, Alanna C and North, Kari E and Omenaas, Ernst and Palmer, Lyle J and Pietilainen, Kirsi H and Pin, Isabelle and Polasek, Ozren and Pouta, Anneli and Psaty, Bruce M and Hartikainen, Anna-Liisa and Rantanen, Taina and Ripatti, Samuli and Rotter, Jerome I and Rudan, Igor and Rudnicka, Alicja R and Schulz, Holger and Shin, So-Youn and Spector, Tim D and Surakka, Ida and Vitart, Veronique and Volzke, Henry and Wareham, Nicholas J and Warrington, Nicole M and Wichmann, H-Erich and Wild, Sarah H and Wilk, Jemma B and Wjst, Matthias and Wright, Alan F and Zgaga, Lina and Zemunik, Tatijana and Pennell, Craig E and Nyberg, Fredrik and Kuh, Diana and Holloway, John W and Boezen, H Marike and Lawlor, Debbie A and Morris, Richard W and Probst-Hensch, Nicole and Kaprio, Jaakko and Wilson, James F and Hayward, Caroline and Kahonen, Mika and Heinrich, Joachim and Musk, Arthur W and Jarvis, Deborah L and Glaser, Sven and Jarvelin, Marjo-Riitta and Stricker, Bruno HC and Elliott, Paul and O'Connor, George T and Strachan, David P and London, Stephanie J and Hall, Ian P and Gudnason, Vilmundur and Tobin, Martin D},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {POLYMORPHISMS,POPULATION,OBSTRUCTIVE PULMONARY-DISEASE,GENETIC-VARIATION,BLOOD-PRESSURE,VARIANTS,METAANALYSIS,PROTEIN,RISK,EXPRESSION},
  language     = {eng},
  number       = {11},
  pages        = {1082--U70},
  title        = {Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function},
  url          = {http://dx.doi.org/10.1038/ng.941},
  volume       = {43},
  year         = {2011},
}

Chicago
Artigas, Maria Soler, Daan W Loth, Louise V Wain, Sina A Gharib, Ma’en Obeidat, Wenbo Tang, Guangju Zhai, et al. 2011. “Genome-wide Association and Large-scale Follow up Identifies 16 New Loci Influencing Lung Function.” Nature Genetics 43 (11): 1082–U70.
APA
Artigas, M. S., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., Zhai, G., et al. (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. NATURE GENETICS, 43(11), 1082–U70.
Vancouver
1.
Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. NATURE GENETICS. 2011;43(11):1082–U70.
MLA
Artigas, Maria Soler, Daan W Loth, Louise V Wain, et al. “Genome-wide Association and Large-scale Follow up Identifies 16 New Loci Influencing Lung Function.” NATURE GENETICS 43.11 (2011): 1082–U70. Print.