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The PIDDosome, DNA-damage-induced apoptosis and beyond

Sophie Janssens (UGent) and A Tinel
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Abstract
P53-induced protein with a death domain (PIDD) was cloned as a death domain (DD)-containing protein whose expression is induced by p53. It was later described as the core of a molecular platform-activating caspase-2, named the PIDDosome. These first results pointed towards a role for PIDD in apoptosis, in response to DNA damage. Identification of new PIDDosome complexes involved in DNA repair and nuclear factor-kappa B signaling challenged this early concept. PIDD functions are growing as new complexes and new interaction partners are being discovered, and as additional functions are being revealed. A fascinating feature of PIDD lies within its complex and tight regulation mechanisms, which allow the molecule to fine-tune its different functions: from transcriptional regulation to the expression of different isoforms, and from the interaction with regulatory proteins to an ingenious post-translational cleavage mechanism generating various active fragments with specific functions. Further studies still need to be carried out to provide answers to many unresolved issues and to reconcile conflicting results. This review aims at providing an overview of the current PIDD knowledge status
Keywords
PIDDosome, DNA damage, caspase-2, PIDD, apoptosis, KAPPA-B ACTIVATION, DEATH DOMAIN PIDD, CASPASE-2 ACTIVATION, P53-INDUCED PROTEIN, GENOTOXIC STRESS, CYTOCHROME-C, MEDIATED APOPTOSIS, REGULATES P53, EXPRESSION, COMPLEX

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Chicago
Janssens, Sophie, and A Tinel. 2012. “The PIDDosome, DNA-damage-induced Apoptosis and Beyond.” Cell Death and Differentiation 19 (1): 13–20.
APA
Janssens, Sophie, & Tinel, A. (2012). The PIDDosome, DNA-damage-induced apoptosis and beyond. CELL DEATH AND DIFFERENTIATION, 19(1), 13–20.
Vancouver
1.
Janssens S, Tinel A. The PIDDosome, DNA-damage-induced apoptosis and beyond. CELL DEATH AND DIFFERENTIATION. 2012;19(1):13–20.
MLA
Janssens, Sophie, and A Tinel. “The PIDDosome, DNA-damage-induced Apoptosis and Beyond.” CELL DEATH AND DIFFERENTIATION 19.1 (2012): 13–20. Print.
@article{2022825,
  abstract     = {P53-induced protein with a death domain (PIDD) was cloned as a death domain (DD)-containing protein whose expression is induced by p53. It was later described as the core of a molecular platform-activating caspase-2, named the PIDDosome. These first results pointed towards a role for PIDD in apoptosis, in response to DNA damage. Identification of new PIDDosome complexes involved in DNA repair and nuclear factor-kappa B signaling challenged this early concept. PIDD functions are growing as new complexes and new interaction partners are being discovered, and as additional functions are being revealed. A fascinating feature of PIDD lies within its complex and tight regulation mechanisms, which allow the molecule to fine-tune its different functions: from transcriptional regulation to the expression of different isoforms, and from the interaction with regulatory proteins to an ingenious post-translational cleavage mechanism generating various active fragments with specific functions. Further studies still need to be carried out to provide answers to many unresolved issues and to reconcile conflicting results. This review aims at providing an overview of the current PIDD knowledge status},
  author       = {Janssens, Sophie and Tinel, A},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  keyword      = {PIDDosome,DNA damage,caspase-2,PIDD,apoptosis,KAPPA-B ACTIVATION,DEATH DOMAIN PIDD,CASPASE-2 ACTIVATION,P53-INDUCED PROTEIN,GENOTOXIC STRESS,CYTOCHROME-C,MEDIATED APOPTOSIS,REGULATES P53,EXPRESSION,COMPLEX},
  language     = {eng},
  number       = {1},
  pages        = {13--20},
  title        = {The PIDDosome, DNA-damage-induced apoptosis and beyond},
  url          = {http://dx.doi.org/10.1038/cdd.2011.162},
  volume       = {19},
  year         = {2012},
}

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