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The PIDDosome, DNA-damage-induced apoptosis and beyond

Sophie Janssens UGent and A Tinel (2012) CELL DEATH AND DIFFERENTIATION. 19(1). p.13-20
abstract
P53-induced protein with a death domain (PIDD) was cloned as a death domain (DD)-containing protein whose expression is induced by p53. It was later described as the core of a molecular platform-activating caspase-2, named the PIDDosome. These first results pointed towards a role for PIDD in apoptosis, in response to DNA damage. Identification of new PIDDosome complexes involved in DNA repair and nuclear factor-kappa B signaling challenged this early concept. PIDD functions are growing as new complexes and new interaction partners are being discovered, and as additional functions are being revealed. A fascinating feature of PIDD lies within its complex and tight regulation mechanisms, which allow the molecule to fine-tune its different functions: from transcriptional regulation to the expression of different isoforms, and from the interaction with regulatory proteins to an ingenious post-translational cleavage mechanism generating various active fragments with specific functions. Further studies still need to be carried out to provide answers to many unresolved issues and to reconcile conflicting results. This review aims at providing an overview of the current PIDD knowledge status
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
PIDDosome, DNA damage, caspase-2, PIDD, apoptosis, KAPPA-B ACTIVATION, DEATH DOMAIN PIDD, CASPASE-2 ACTIVATION, P53-INDUCED PROTEIN, GENOTOXIC STRESS, CYTOCHROME-C, MEDIATED APOPTOSIS, REGULATES P53, EXPRESSION, COMPLEX
journal title
CELL DEATH AND DIFFERENTIATION
Cell Death Differ.
volume
19
issue
1
pages
13 - 20
Web of Science type
Review
Web of Science id
000298369000003
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
8.371 (2012)
JCR rank
26/288 (2012)
JCR quartile
1 (2012)
ISSN
1350-9047
DOI
10.1038/cdd.2011.162
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2022825
handle
http://hdl.handle.net/1854/LU-2022825
date created
2012-02-07 17:22:32
date last changed
2016-12-19 15:42:01
@article{2022825,
  abstract     = {P53-induced protein with a death domain (PIDD) was cloned as a death domain (DD)-containing protein whose expression is induced by p53. It was later described as the core of a molecular platform-activating caspase-2, named the PIDDosome. These first results pointed towards a role for PIDD in apoptosis, in response to DNA damage. Identification of new PIDDosome complexes involved in DNA repair and nuclear factor-kappa B signaling challenged this early concept. PIDD functions are growing as new complexes and new interaction partners are being discovered, and as additional functions are being revealed. A fascinating feature of PIDD lies within its complex and tight regulation mechanisms, which allow the molecule to fine-tune its different functions: from transcriptional regulation to the expression of different isoforms, and from the interaction with regulatory proteins to an ingenious post-translational cleavage mechanism generating various active fragments with specific functions. Further studies still need to be carried out to provide answers to many unresolved issues and to reconcile conflicting results. This review aims at providing an overview of the current PIDD knowledge status},
  author       = {Janssens, Sophie and Tinel, A},
  issn         = {1350-9047},
  journal      = {CELL DEATH AND DIFFERENTIATION},
  keyword      = {PIDDosome,DNA damage,caspase-2,PIDD,apoptosis,KAPPA-B ACTIVATION,DEATH DOMAIN PIDD,CASPASE-2 ACTIVATION,P53-INDUCED PROTEIN,GENOTOXIC STRESS,CYTOCHROME-C,MEDIATED APOPTOSIS,REGULATES P53,EXPRESSION,COMPLEX},
  language     = {eng},
  number       = {1},
  pages        = {13--20},
  title        = {The PIDDosome, DNA-damage-induced apoptosis and beyond},
  url          = {http://dx.doi.org/10.1038/cdd.2011.162},
  volume       = {19},
  year         = {2012},
}

Chicago
Janssens, Sophie, and A Tinel. 2012. “The PIDDosome, DNA-damage-induced Apoptosis and Beyond.” Cell Death and Differentiation 19 (1): 13–20.
APA
Janssens, Sophie, & Tinel, A. (2012). The PIDDosome, DNA-damage-induced apoptosis and beyond. CELL DEATH AND DIFFERENTIATION, 19(1), 13–20.
Vancouver
1.
Janssens S, Tinel A. The PIDDosome, DNA-damage-induced apoptosis and beyond. CELL DEATH AND DIFFERENTIATION. 2012;19(1):13–20.
MLA
Janssens, Sophie, and A Tinel. “The PIDDosome, DNA-damage-induced Apoptosis and Beyond.” CELL DEATH AND DIFFERENTIATION 19.1 (2012): 13–20. Print.