- Author
- Meta M Bloksma, Stephanie Hoeppener, Cécile D'Haese, Kristian Kempe, Ulrich Mansfeld, Renzo M Paulus, Jean-François Gohy, Ulrich S Schubert and Richard Hoogenboom (UGent)
- Organization
- Abstract
- Chiral micelles have a high potential for targeted drug delivery or chiral separation applications. In this contribution the self-assembly of chiral amphiphilic copolymers into chiral structures was investigated. Gradient copolymers could be obtained by statistically copolymerizing the hydrophilic 2-ethyl-2-oxazoline (EtOx) with the hydrophobic chiral R-2-butyl-4-ethyl-2-oxazoline (R-BuEtOx) or racemic RS-BuEtOx monomers. Self-assembly of the gradient enantiopure copolymers was studied by both cryogenic transmission electron spectroscopy (cryo-TEM) and dynamic light scattering (DLS) revealing the formation of spherical micelles in aqueous solution. Additionally, amphiphilic block copolymers were synthesized in a 1-pot-2-step manner. The type of self-assembled structure could be controlled by varying the hydrophobic to hydrophilic ratio within the block copolymer from spherical and cylindrical micelles to sheets and vesicles. When the enantiopure block was replaced by the corresponding racemic block, only spherical micelles could be observed, while the chiral block copolymers with similar hydrophobic content revealed cylindrical micelles.
- Keywords
- MICELLES, DIBLOCK COPOLYMER, POLYMERIZATION, WATER, 2-ETHYL-2-OXAZOLINE, DELIVERY, POLYMERS, BEHAVIOR
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-2020378
- MLA
- Bloksma, Meta M., et al. “Self-Assembly of Chiral Block and Gradient Copolymers.” SOFT MATTER, vol. 8, no. 1, 2012, pp. 165–72, doi:10.1039/c1sm06595e.
- APA
- Bloksma, M. M., Hoeppener, S., D’Haese, C., Kempe, K., Mansfeld, U., Paulus, R. M., … Hoogenboom, R. (2012). Self-assembly of chiral block and gradient copolymers. SOFT MATTER, 8(1), 165–172. https://doi.org/10.1039/c1sm06595e
- Chicago author-date
- Bloksma, Meta M, Stephanie Hoeppener, Cécile D’Haese, Kristian Kempe, Ulrich Mansfeld, Renzo M Paulus, Jean-François Gohy, Ulrich S Schubert, and Richard Hoogenboom. 2012. “Self-Assembly of Chiral Block and Gradient Copolymers.” SOFT MATTER 8 (1): 165–72. https://doi.org/10.1039/c1sm06595e.
- Chicago author-date (all authors)
- Bloksma, Meta M, Stephanie Hoeppener, Cécile D’Haese, Kristian Kempe, Ulrich Mansfeld, Renzo M Paulus, Jean-François Gohy, Ulrich S Schubert, and Richard Hoogenboom. 2012. “Self-Assembly of Chiral Block and Gradient Copolymers.” SOFT MATTER 8 (1): 165–172. doi:10.1039/c1sm06595e.
- Vancouver
- 1.Bloksma MM, Hoeppener S, D’Haese C, Kempe K, Mansfeld U, Paulus RM, et al. Self-assembly of chiral block and gradient copolymers. SOFT MATTER. 2012;8(1):165–72.
- IEEE
- [1]M. M. Bloksma et al., “Self-assembly of chiral block and gradient copolymers,” SOFT MATTER, vol. 8, no. 1, pp. 165–172, 2012.
@article{2020378, abstract = {{Chiral micelles have a high potential for targeted drug delivery or chiral separation applications. In this contribution the self-assembly of chiral amphiphilic copolymers into chiral structures was investigated. Gradient copolymers could be obtained by statistically copolymerizing the hydrophilic 2-ethyl-2-oxazoline (EtOx) with the hydrophobic chiral R-2-butyl-4-ethyl-2-oxazoline (R-BuEtOx) or racemic RS-BuEtOx monomers. Self-assembly of the gradient enantiopure copolymers was studied by both cryogenic transmission electron spectroscopy (cryo-TEM) and dynamic light scattering (DLS) revealing the formation of spherical micelles in aqueous solution. Additionally, amphiphilic block copolymers were synthesized in a 1-pot-2-step manner. The type of self-assembled structure could be controlled by varying the hydrophobic to hydrophilic ratio within the block copolymer from spherical and cylindrical micelles to sheets and vesicles. When the enantiopure block was replaced by the corresponding racemic block, only spherical micelles could be observed, while the chiral block copolymers with similar hydrophobic content revealed cylindrical micelles.}}, author = {{Bloksma, Meta M and Hoeppener, Stephanie and D'Haese, Cécile and Kempe, Kristian and Mansfeld, Ulrich and Paulus, Renzo M and Gohy, Jean-François and Schubert, Ulrich S and Hoogenboom, Richard}}, issn = {{1744-683X}}, journal = {{SOFT MATTER}}, keywords = {{MICELLES,DIBLOCK COPOLYMER,POLYMERIZATION,WATER,2-ETHYL-2-OXAZOLINE,DELIVERY,POLYMERS,BEHAVIOR}}, language = {{eng}}, number = {{1}}, pages = {{165--172}}, title = {{Self-assembly of chiral block and gradient copolymers}}, url = {{http://doi.org/10.1039/c1sm06595e}}, volume = {{8}}, year = {{2012}}, }
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