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Arabidopsis α Aurora kinases function in formative cell division plane orientation

(2011) PLANT CELL. 23(11). p.4013-4024
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Abstract
To establish three-dimensional structures/organs, plant cells continuously have to adapt the orientation of their division plane in a highly regulated manner. However, mechanisms underlying switches in division plane orientation remain elusive. Here, we characterize a viable double knockdown mutant in Arabidopsis thaliana group alpha Aurora (AUR) kinases, AUR1 and AUR2, (aur1-2 aur2-2), with a primary defect in lateral root formation and outgrowth. Mutant analysis revealed that aur1-2 aur2-2 lateral root primordia are built from randomly oriented cell divisions instead of distinct cell layers. This phenotype could be traced back to cytokinesis defects and misoriented cell plates during the initial anticlinal pericycle cell divisions that give rise to lateral root primordia. Complementation assays showed that the Arabidopsis alpha group Aurora kinases are functionally divergent from the single beta group member AUR3 and that AUR1 functions in division plane orientation prior to cytokinesis. In addition to defective lateral root patterning, aur1-2 aur2-2 plants also show defects in orienting formative divisions during embryogenesis, divisions surrounding the main root stem cell niche, and divisions surrounding stomata formation. Taken together, our results put forward a central role for alpha Aurora kinases in regulating formative division plane orientation throughout development.
Keywords
MITOSIS, ACTIVATION, ASYMMETRIC DIVISION, PREPROPHASE BAND FORMATION, HISTONE H3, REVEALS, PROTEIN, PHOSPHORYLATION, LOCALIZATION, IDENTIFICATION

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MLA
Van Damme, Daniël et al. “Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation.” PLANT CELL 23.11 (2011): 4013–4024. Print.
APA
Van Damme, Daniël, De Rybel, B., Gudesblat, G., Demidov, D., Grunewald, W., De Smet, I., Houben, A., et al. (2011). Arabidopsis α Aurora kinases function in formative cell division plane orientation. PLANT CELL, 23(11), 4013–4024.
Chicago author-date
Van Damme, Daniël, Bert De Rybel, Gustavo Gudesblat, Dmitri Demidov, Wim Grunewald, Ive De Smet, Andreas Houben, Tom Beeckman, and Eugenia Russinova. 2011. “Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation.” Plant Cell 23 (11): 4013–4024.
Chicago author-date (all authors)
Van Damme, Daniël, Bert De Rybel, Gustavo Gudesblat, Dmitri Demidov, Wim Grunewald, Ive De Smet, Andreas Houben, Tom Beeckman, and Eugenia Russinova. 2011. “Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation.” Plant Cell 23 (11): 4013–4024.
Vancouver
1.
Van Damme D, De Rybel B, Gudesblat G, Demidov D, Grunewald W, De Smet I, et al. Arabidopsis α Aurora kinases function in formative cell division plane orientation. PLANT CELL. 2011;23(11):4013–24.
IEEE
[1]
D. Van Damme et al., “Arabidopsis α Aurora kinases function in formative cell division plane orientation,” PLANT CELL, vol. 23, no. 11, pp. 4013–4024, 2011.
@article{2018892,
  abstract     = {To establish three-dimensional structures/organs, plant cells continuously have to adapt the orientation of their division plane in a highly regulated manner. However, mechanisms underlying switches in division plane orientation remain elusive. Here, we characterize a viable double knockdown mutant in Arabidopsis thaliana group alpha Aurora (AUR) kinases, AUR1 and AUR2, (aur1-2 aur2-2), with a primary defect in lateral root formation and outgrowth. Mutant analysis revealed that aur1-2 aur2-2 lateral root primordia are built from randomly oriented cell divisions instead of distinct cell layers. This phenotype could be traced back to cytokinesis defects and misoriented cell plates during the initial anticlinal pericycle cell divisions that give rise to lateral root primordia. Complementation assays showed that the Arabidopsis alpha group Aurora kinases are functionally divergent from the single beta group member AUR3 and that AUR1 functions in division plane orientation prior to cytokinesis. In addition to defective lateral root patterning, aur1-2 aur2-2 plants also show defects in orienting formative divisions during embryogenesis, divisions surrounding the main root stem cell niche, and divisions surrounding stomata formation. Taken together, our results put forward a central role for alpha Aurora kinases in regulating formative division plane orientation throughout development.},
  author       = {Van Damme, Daniël and De Rybel, Bert and Gudesblat, Gustavo and Demidov, Dmitri and Grunewald, Wim and De Smet, Ive and Houben, Andreas and Beeckman, Tom and Russinova, Eugenia},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keywords     = {MITOSIS,ACTIVATION,ASYMMETRIC DIVISION,PREPROPHASE BAND FORMATION,HISTONE H3,REVEALS,PROTEIN,PHOSPHORYLATION,LOCALIZATION,IDENTIFICATION},
  language     = {eng},
  number       = {11},
  pages        = {4013--4024},
  title        = {Arabidopsis α Aurora kinases function in formative cell division plane orientation},
  url          = {http://dx.doi.org/10.1105/tpc.111.089565},
  volume       = {23},
  year         = {2011},
}

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