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Arabidopsis α Aurora kinases function in formative cell division plane orientation

Daniël Van Damme UGent, Bert De Rybel UGent, Gustavo Gudesblat UGent, Dmitri Demidov, Wim Grunewald UGent, Ive De Smet UGent, Andreas Houben, Tom Beeckman UGent and Eugenia Russinova UGent (2011) PLANT CELL. 23(11). p.4013-4024
abstract
To establish three-dimensional structures/organs, plant cells continuously have to adapt the orientation of their division plane in a highly regulated manner. However, mechanisms underlying switches in division plane orientation remain elusive. Here, we characterize a viable double knockdown mutant in Arabidopsis thaliana group alpha Aurora (AUR) kinases, AUR1 and AUR2, (aur1-2 aur2-2), with a primary defect in lateral root formation and outgrowth. Mutant analysis revealed that aur1-2 aur2-2 lateral root primordia are built from randomly oriented cell divisions instead of distinct cell layers. This phenotype could be traced back to cytokinesis defects and misoriented cell plates during the initial anticlinal pericycle cell divisions that give rise to lateral root primordia. Complementation assays showed that the Arabidopsis alpha group Aurora kinases are functionally divergent from the single beta group member AUR3 and that AUR1 functions in division plane orientation prior to cytokinesis. In addition to defective lateral root patterning, aur1-2 aur2-2 plants also show defects in orienting formative divisions during embryogenesis, divisions surrounding the main root stem cell niche, and divisions surrounding stomata formation. Taken together, our results put forward a central role for alpha Aurora kinases in regulating formative division plane orientation throughout development.
Please use this url to cite or link to this publication:
author
organization
alternative title
Arabidopsis alpha Aurora kinases function in formative cell division plane orientation
year
type
journalArticle (original)
publication status
published
subject
keyword
MITOSIS, ACTIVATION, ASYMMETRIC DIVISION, PREPROPHASE BAND FORMATION, HISTONE H3, REVEALS, PROTEIN, PHOSPHORYLATION, LOCALIZATION, IDENTIFICATION
journal title
PLANT CELL
Plant Cell
volume
23
issue
11
pages
4013 - 4024
Web of Science type
Article
Web of Science id
000298674200014
JCR category
PLANT SCIENCES
JCR impact factor
8.987 (2011)
JCR rank
5/189 (2011)
JCR quartile
1 (2011)
ISSN
1040-4651
DOI
10.1105/tpc.111.089565
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
2018892
handle
http://hdl.handle.net/1854/LU-2018892
date created
2012-02-03 14:43:09
date last changed
2012-12-17 16:50:50
@article{2018892,
  abstract     = {To establish three-dimensional structures/organs, plant cells continuously have to adapt the orientation of their division plane in a highly regulated manner. However, mechanisms underlying switches in division plane orientation remain elusive. Here, we characterize a viable double knockdown mutant in Arabidopsis thaliana group alpha Aurora (AUR) kinases, AUR1 and AUR2, (aur1-2 aur2-2), with a primary defect in lateral root formation and outgrowth. Mutant analysis revealed that aur1-2 aur2-2 lateral root primordia are built from randomly oriented cell divisions instead of distinct cell layers. This phenotype could be traced back to cytokinesis defects and misoriented cell plates during the initial anticlinal pericycle cell divisions that give rise to lateral root primordia. Complementation assays showed that the Arabidopsis alpha group Aurora kinases are functionally divergent from the single beta group member AUR3 and that AUR1 functions in division plane orientation prior to cytokinesis. In addition to defective lateral root patterning, aur1-2 aur2-2 plants also show defects in orienting formative divisions during embryogenesis, divisions surrounding the main root stem cell niche, and divisions surrounding stomata formation. Taken together, our results put forward a central role for alpha Aurora kinases in regulating formative division plane orientation throughout development.},
  author       = {Van Damme, Dani{\"e}l and De Rybel, Bert and Gudesblat, Gustavo and Demidov, Dmitri and Grunewald, Wim and De Smet, Ive and Houben, Andreas and Beeckman, Tom and Russinova, Eugenia},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {MITOSIS,ACTIVATION,ASYMMETRIC DIVISION,PREPROPHASE BAND FORMATION,HISTONE H3,REVEALS,PROTEIN,PHOSPHORYLATION,LOCALIZATION,IDENTIFICATION},
  language     = {eng},
  number       = {11},
  pages        = {4013--4024},
  title        = {Arabidopsis \ensuremath{\alpha} Aurora kinases function in formative cell division plane orientation},
  url          = {http://dx.doi.org/10.1105/tpc.111.089565},
  volume       = {23},
  year         = {2011},
}

Chicago
Van Damme, Daniël, Bert De Rybel, Gustavo Gudesblat, Dmitri Demidov, Wim Grunewald, Ive De Smet, Andreas Houben, Tom Beeckman, and Eugenia Russinova. 2011. “Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation.” Plant Cell 23 (11): 4013–4024.
APA
Van Damme, Daniël, De Rybel, B., Gudesblat, G., Demidov, D., Grunewald, W., De Smet, I., Houben, A., et al. (2011). Arabidopsis α Aurora kinases function in formative cell division plane orientation. PLANT CELL, 23(11), 4013–4024.
Vancouver
1.
Van Damme D, De Rybel B, Gudesblat G, Demidov D, Grunewald W, De Smet I, et al. Arabidopsis α Aurora kinases function in formative cell division plane orientation. PLANT CELL. 2011;23(11):4013–24.
MLA
Van Damme, Daniël, Bert De Rybel, Gustavo Gudesblat, et al. “Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation.” PLANT CELL 23.11 (2011): 4013–4024. Print.